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| AGEL Open 2022 | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tereza Martincova | Loss | 6-7 (3-7), 0-1 Retired |
| Tallinn Open | ||
| Surface: Hard | Date: Sep. 26 - Oct. 2 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Xiyu Wang | Win | 3-6, 6-2, 7-5 |
| Second Round | Tereza Martincova | Win | |
| Quarterfinals | Ysaline Bonaventure | Win | |
| Semifinals | Kaia Kanepi | Win | |
| Final | Barbora Krejcikova | Loss |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jaqueline Cristian | Win | 6-3, 6-0 |
| Second Round | Serena Williams | Loss | 6-7 (4-7), 6-2, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tereza Martincova | Win | |
| Third Round | Shuai Zhang | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jil Teichmann | Loss |
| Livesport Prague Open | ||
| Surface: Clay | Date: Jul. 25 - Jul. 31 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterine Gorgodze | Win | |
| Second Round | Lucie Havlickova | Win | |
| Quarterfinals | Anastasia Potapova | Loss |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 17 - Jul. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Irina Bara | Win | |
| Second Round | Rebecca Peterson | Win | |
| Quarterfinals | Andrea Petkovic | Win | |
| Semifinals | Anastasia Potapova | Win | |
| Final | Bernarda Pera | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | |
| Second Round | Jule Niemeier | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Martic | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Angelique Kerber | Win | |
| Second Round | Ekaterina Alexandrova | Win | |
| Quarterfinals | Aryna Sabalenka | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ann Li | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Kucova | Win | |
| Third Round | Marketa Vondrousova | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ana Konjuh | Win | |
| Third Round | Elise Mertens | Win | |
| Quarterfinals | Ons Jabeur | Win | |
| Semifinals | Jelena Ostapenko | Win | |
| Final | Iga Swiatek | Loss |
| St. Petersburg Ladies' Trophy | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jil Teichmann | Win | |
| Second Round | Sorana Cirstea | Win | |
| Quarterfinals | Belinda Bencic | Win | |
| Semifinals | Jelena Ostapenko | Win | |
| Final | Maria Sakkari | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | |
| Second Round | Clara Tauson | Loss |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Win | |
| Second Round | Elena-Gabriela Ruse | Win | |
| Quarterfinals | Ons Jabeur | Win | |
| Semifinals | Barbora Krejcikova | Loss |
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