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| China Open | ||
| Surface: Hard | Date: Oct. 1 - Oct. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 25 - Oct. 2 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Irina-Camelia Begu | Win | 6-3, 2-0 Retired |
| Third Round | Yaroslava Shvedova | Win | 6-3, 6-3 |
| Quarterfinals | Madison Keys | Win | 6-4, 6-2 |
| Semifinals | Petra Kvitova | Loss | 1-6, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Kirsten Flipkens | Win | 6-0, 6-2 |
| Second Round | Lucie Safarova | Win | 6-3, 6-4 |
| Third Round | Timea Babos | Win | 6-1, 2-6, 6-4 |
| Fourth Round | Carla Suarez Navarro | Win | 6-2, 7-5 |
| Quarterfinals | Serena Williams | Loss | 2-6, 6-4, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Annika Beck | Win | 6-3, 6-1 |
| Third Round | Daria Gavrilova | Win | 6-1, 6-2 |
| Quarterfinals | Agnieszka Radwanska | Win | 7-5, 6-1 |
| Semifinals | Angelique Kerber | Loss | 3-6, 4-6 |
| Rogers Cup | ||
| Surface: Hard | Date: Jul. 25 - Jul. 31 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Gavrilova | Win | 6-2, 6-3 |
| Third Round | Karolina Pliskova | Win | 6-3, 6-3 |
| Quarterfinals | Svetlana Kuznetsova | Win | 3-6, 6-1, 6-1 |
| Semifinals | Angelique Kerber | Win | 6-0, 3-6, 6-2 |
| Final | Madison Keys | Win | 7-6 (7-2), 6-3 |
| BRD Bucharest Open | ||
| Surface: Red Clay | Date: Jul. 11 - Jul. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Barbora Krejcikova | Win | 3-6, 6-1, 6-1 |
| Second Round | Isabella Shinikova | Win | 6-4, 6-3 |
| Quarterfinals | Danka Kovinic | Win | 6-4, 6-2 |
| Semifinals | Vania King | Win | 6-7 (3-7), 6-4, 6-3 |
| Final | Anastasija Sevastova | Win | 6-0, 6-0 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Anna Karolina Schmiedlova | Win | 6-4, 6-1 |
| Second Round | Francesca Schiavone | Win | 6-1, 6-1 |
| Third Round | Kiki Bertens | Win | 6-4, 6-3 |
| Fourth Round | Madison Keys | Win | 6-7 (5-7), 6-4, 6-3 |
| Quarterfinals | Angelique Kerber | Loss | 5-7, 6-7 (2-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Nao Hibino | Win | 6-2, 6-0 |
| Second Round | Zarina Diyas | Win | 7-6 (7-5), 6-2 |
| Third Round | Naomi Osaka | Win | 4-6, 6-2, 6-3 |
| Fourth Round | Samantha Stosur | Loss | 6-7 (0-7), 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Gavrilova | Loss | 3-6, 6-4, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: Apr. 30 - May 8 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Misaki Doi | Win | 6-0, 6-3 |
| Second Round | Karin Knapp | Win | 6-1, 6-1 |
| Third Round | Timea Bacsinszky | Win | 6-2, 6-3 |
| Quarterfinals | Irina-Camelia Begu | Win | 6-3, 0-6, 6-1 |
| Semifinals | Samantha Stosur | Win | 6-2, 6-0 |
| Final | Dominika Cibulkova | Win | 6-2, 6-4 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laura Siegemund | Loss | 1-6, 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Win | 6-3, 7-5 |
| Third Round | Julia Goerges | Win | 6-4, 6-1 |
| Fourth Round | Heather Watson | Win | 6-3, 6-4 |
| Quarterfinals | Timea Bacsinszky | Loss | 6-4, 3-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Vania King | Win | 6-1, 6-1 |
| Third Round | Ekaterina Makarova | Win | 6-2, 6-4 |
| Fourth Round | Barbora Strycova | Win | 6-3, 1-0 Retired |
| Quarterfinals | Serena Williams | Loss | 4-6, 3-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 21 - Feb. 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena Vesnina | Loss | 7-6 (7-1), 4-6, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 15 - Feb. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ana Ivanovic | Loss | 6-7 (2-7), 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Loss | 4-6, 3-6 |
| Apia International Sydney | ||
| Surface: Hard | Date: Jan. 10 - Jan. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Garcia | Win | 6-4, 2-6, 6-1 |
| Quarterfinals | Karolina Pliskova | Win | 6-4, 7-5 |
| Semifinals | Svetlana Kuznetsova | Loss | 6-7 (5-7), 6-4, 3-6 |
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