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| China Open | ||
| Surface: Hard | Date: Sep. 30 - Oct. 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 6-3, 3-6, 6-2 |
| Second Round | Magdalena Rybarikova | Win | 6-1, 2-1 Retired |
| Third Round | Maria Sharapova | Win | 6-2, 6-2 |
| Quarterfinals | Daria Kasatkina | Win | 6-2, 6-1 |
| Semifinals | Jelena Ostapenko | Win | 6-2, 6-4 |
| Final | Caroline Garcia | Loss | 4-6, 6-7 (6-8) |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 24 - Sep. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Loss | 2-6, 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sharapova | Loss | 4-6, 6-4, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Townsend | Win | 6-4, 6-1 |
| Third Round | Anastasija Sevastova | Win | 6-4, 6-3 |
| Quarterfinals | Johanna Konta | Win | 6-4, 7-6 (7-1) |
| Semifinals | Sloane Stephens | Win | 6-2, 6-1 |
| Final | Garbine Muguruza | Loss | 1-6, 0-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Rybarikova | Win | 6-3, 6-4 |
| Third Round | Barbora Strycova | Win | 6-1, 6-0 |
| Quarterfinals | Caroline Garcia | Win | 6-4, 6-2 |
| Semifinals | Elina Svitolina | Loss | 1-6, 1-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Sloane Stephens | Win | 7-6 (7-3), 6-0 |
| Second Round | Mariana Duque-Marino | Win | 3-6, 6-4, 6-2 |
| Quarterfinals | Ekaterina Makarova | Loss | 6-2, 3-6, 0-1 Retired |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Marina Erakovic | Win | 6-4, 6-1 |
| Second Round | Beatriz Haddad Maia | Win | 7-5, 6-3 |
| Third Round | Shuai Peng | Win | 6-4, 7-6 (9-7) |
| Fourth Round | Victoria Azarenka | Win | 7-6 (7-3), 6-2 |
| Quarterfinals | Johanna Konta | Loss | 7-6 (7-2), 6-7 (5-7), 4-6 |
| AEGON International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ying-Ying Duan | Win | 3-6, 6-3, 6-2 |
| Third Round | Tsvetana Pironkova | Win | 6-7 (6-8), 7-6 (7-4), 7-5 |
| Quarterfinals | Caroline Wozniacki | Loss | 7-5, 4-6, 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Jana Cepelova | Win | 6-2, 6-3 |
| Second Round | Tatjana Maria | Win | 6-4, 6-3 |
| Third Round | Daria Kasatkina | Win | 6-0, 7-5 |
| Fourth Round | Carla Suarez Navarro | Win | 6-1, 6-1 |
| Quarterfinals | Elina Svitolina | Win | 3-6, 7-6 (8-6), 6-0 |
| Semifinals | Karolina Pliskova | Win | 6-4, 3-6, 6-3 |
| Final | Jelena Ostapenko | Loss | 6-4, 4-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laura Siegemund | Win | 6-4, 6-4 |
| Third Round | Anastasia Pavlyuchenkova | Win | 6-1, 4-6, 6-0 |
| Quarterfinals | Anett Kontaveit | Win | 6-2, 6-4 |
| Semifinals | Kiki Bertens | Win | 7-5, 6-1 |
| Final | Elina Svitolina | Loss | 6-4, 5-7, 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Kristyna Pliskova | Win | 6-1, 6-2 |
| Second Round | Roberta Vinci | Win | 6-3, 2-6, 7-6 (7-2) |
| Third Round | Samantha Stosur | Win | 6-4, 4-6, 6-4 |
| Quarterfinals | Coco Vandeweghe | Win | 6-1, 6-1 |
| Semifinals | Anastasija Sevastova | Win | 6-2, 6-3 |
| Final | Kristina Mladenovic | Win | 7-5, 6-7 (5-7), 6-2 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Strycova | Win | 6-2, 6-3 |
| Quarterfinals | Anastasija Sevastova | Win | 6-3, 6-1 |
| Semifinals | Laura Siegemund | Loss | 4-6, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Naomi Osaka | Win | 6-4, 2-6, 6-3 |
| Third Round | Anett Kontaveit | Win | 6-3, 6-0 |
| Fourth Round | Samantha Stosur | Win | 4-6, 7-5, 6-2 |
| Quarterfinals | Johanna Konta | Loss | 6-3, 6-7 (7-9), 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Donna Vekic | Win | 6-4, 6-1 |
| Third Round | Kristina Mladenovic | Loss | 3-6, 3-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 30 - Feb. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ana Konjuh | Win | 6-4, 7-6 (7-2) |
| Quarterfinals | Natalia Vikhlyantseva | Loss | Retired |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Loss | 3-6, 1-6 |
| Shenzhen Gemdale Open | ||
| Surface: Hard | Date: Jan. 1 - Jan. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jelena Jankovic | Win | 6-1, 3-6, 6-3 |
| Second Round | Katerina Siniakova | Loss | 3-6, 6-4, 5-7 |
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