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| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Aliaksandra Sasnovich | Win | 6-4, 7-5 |
| Second Round | Mihaela Buzarnescu | Win | 6-3, 4-6, 6-2 |
| Third Round | Victoria Azarenka | Win | 6-3, 6-1 |
| Fourth Round | Cori Gauff | Win | 6-3, 6-3 |
| Quarterfinals | Shuai Zhang | Win | 7-6 (7-4), 6-1 |
| Semifinals | Elina Svitolina | Win | 6-1, 6-3 |
| Final | Serena Williams | Win | 6-2, 6-2 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Su-Wei Hsieh | Win | 6-2, 6-0 |
| Third Round | Polona Hercog | Win | 6-1, 4-6, 6-3 |
| Quarterfinals | Angelique Kerber | Loss | 4-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | 6-2, 3-6, 6-1 |
| Second Round | Magda Linette | Win | 6-4, 5-7, 6-3 |
| Third Round | Lesia Tsurenko | Win | 6-2, 6-1 |
| Fourth Round | Iga Swiatek | Win | 6-1, 6-0 |
| Quarterfinals | Amanda Anisimova | Loss | 2-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marketa Vondrousova | Loss | 6-2, 5-7, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Margarita Gasparyan | Win | 6-0, 6-4 |
| Second Round | Johanna Konta | Win | 7-5, 6-1 |
| Third Round | Viktoria Kuzmova | Win | 6-0, 6-0 |
| Quarterfinals | Ashleigh Barty | Win | 7-5, 7-5 |
| Semifinals | Belinda Bencic | Win | 6-2, 6-7 (2-7), 6-0 |
| Final | Kiki Bertens | Loss | 4-6, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Townsend | Win | 6-1, 6-3 |
| Third Round | Polona Hercog | Win | 5-7, 7-6 (7-1), 6-2 |
| Fourth Round | Venus Williams | Win | 6-3, 6-3 |
| Quarterfinals | Qiang Wang | Win | 6-4, 7-5 |
| Semifinals | Karolina Pliskova | Loss | 5-7, 1-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Strycova | Win | 6-2, 6-4 |
| Third Round | Kateryna Kozlova | Win | 7-6 (7-3), 7-5 |
| Fourth Round | Marketa Vondrousova | Loss | 2-6, 6-3, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Eugenie Bouchard | Win | 7-6 (7-4), 6-4 |
| Third Round | Lesia Tsurenko | Win | 6-3, 7-5 |
| Quarterfinals | Belinda Bencic | Loss | 6-4, 4-6, 2-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lesia Tsurenko | Win | 6-2, 6-3 |
| Quarterfinals | Julia Goerges | Win | 7-6 (7-1), 7-6 (8-6) |
| Semifinals | Elina Svitolina | Win | 6-3, 3-6, 6-4 |
| Final | Elise Mertens | Loss | 6-3, 4-6, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Kaia Kanepi | Win | 6-7 (2-7), 6-4, 6-2 |
| Second Round | Sofia Kenin | Win | 6-3, 6-7 (5-7), 6-4 |
| Third Round | Venus Williams | Win | 6-2, 6-3 |
| Fourth Round | Serena Williams | Loss | 1-6, 6-4, 4-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ashleigh Barty | Loss | 4-6, 4-6 |
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