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| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Karin Knapp | Loss | 3-6, 7-6 (8-6), 0-4 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Irina-Camelia Begu | Loss | 3-6, 2-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: Apr. 30 - May 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Laura Robson | Win | 6-4, 6-2 |
| Second Round | Alize Cornet | Win | 6-3, 6-2 |
| Third Round | Louisa Chirico | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Monica Puig | Win | 6-2, 6-4 |
| Third Round | Magda Linette | Win | 6-3, 6-0 |
| Fourth Round | Garbine Muguruza | Win | 7-6 (8-6), 7-6 (7-4) |
| Quarterfinals | Johanna Konta | Win | 6-4, 6-2 |
| Semifinals | Angelique Kerber | Win | 6-2, 7-5 |
| Final | Svetlana Kuznetsova | Win | 6-3, 6-2 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Zarina Diyas | Win | 6-3, 6-2 |
| Third Round | Shuai Zhang | Win | 6-4, 6-3 |
| Fourth Round | Samantha Stosur | Win | 6-1, 4-6, 6-1 |
| Quarterfinals | Magdalena Rybarikova | Win | 6-0, 6-0 |
| Semifinals | Karolina Pliskova | Win | 7-6 (7-1), 1-6, 6-2 |
| Final | Serena Williams | Win | 6-4, 6-4 |
| Abierto Mexicano TELCEL presentado por HSBC | ||
| Surface: Hard | Date: Feb. 22 - Feb. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 4-6, 6-3, 6-1 |
| Second Round | Dominika Cibulkova | Loss | Retired |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Alison Van Uytvanck | Win | 6-0, 6-0 |
| Second Round | Danka Kovinic | Win | 6-1, 6-2 |
| Third Round | Naomi Osaka | Win | 6-1, 6-1 |
| Fourth Round | Barbora Strycova | Win | 6-2, 6-4 |
| Quarterfinals | Angelique Kerber | Loss | 3-6, 5-7 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 2 - Jan. 10 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elena Vesnina | Win | 6-2, 6-0 |
| Second Round | Ysaline Bonaventure | Win | 6-3, 6-2 |
| Quarterfinals | Roberta Vinci | Win | 6-1, 6-2 |
| Semifinals | Samantha Crawford | Win | 6-0, 6-3 |
| Final | Angelique Kerber | Win | 6-3, 6-1 |
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