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| AGEL Open 2022 | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Madison Keys | Win | 5-7, 6-3, 6-3 |
| Second Round | Aliaksandra Sasnovich | Win | 6-7 (5-7), 6-4, 7-5 |
| Toray Pan Pacific Open | ||
| Surface: Hard | Date: Sep. 19 - Sep. 25 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Liudmila Samsonova | Loss | 2-6, 4-6 |
| Zavarovalnica Sava Portoroz | ||
| Surface: Hard | Date: Sep. 12 - Sep. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Laura Siegemund | Win | 6-7 (4-7), 6-4, 7-6 (10-8) |
| Second Round | Tereza Martincova | Win | 6-4, 6-1 |
| Quarterfinals | Lesia Tsurenko | Win | Retired |
| Semifinals | Ana Bogdan | Win | 6-1, 6-1 |
| Final | Katerina Siniakova | Loss | 7-6 (7-4), 6-7 (5-7), 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 25 |
| Round | Opponent | W / L | Result |
| First Round | Clara Burel | Loss | 4-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mayar Sherif | Win | |
| Second Round | Garbine Muguruza | Win | |
| Third Round | Alison Riske-Amritraj | Win | |
| Quarterfinals | Madison Keys | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Marie Bouzkova | Win | |
| Second Round | Coco Gauff | Loss |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daria Kasatkina | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Coco Vandeweghe | Win | |
| Second Round | Bianca Andreescu | Win | |
| Third Round | Qinwen Zheng | Win | |
| Fourth Round | Petra Martic | Win | |
| Quarterfinals | Ajla Tomljanovic | Win | |
| Semifinals | Simona Halep | Win | |
| Final | Ons Jabeur | Win |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lesia Tsurenko | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Jamie Loeb | Win | |
| Second Round | Shelby Rogers | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Arantxa Rus | Win | |
| Second Round | Katie Volynets | Win | |
| Third Round | Madison Keys | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elina Avanesyan | Win | |
| Second Round | Lauren Davis | Win | |
| Third Round | Jil Teichmann | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Oceane Dodin | Win | |
| Second Round | Katerina Siniakova | Win | |
| Third Round | Jil Teichmann | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Nastasja Schunk | Win | |
| Second Round | Paula Badosa | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 4 - Apr. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anhelina Kalinina | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena-Gabriela Ruse | Win | |
| Third Round | Jessica Pegula | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Van Uytvanck | Win | |
| Third Round | Victoria Azarenka | Win | |
| Fourth Round | Viktorija Golubic | Win | |
| Quarterfinals | Maria Sakkari | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Jaqueline Cristian | Loss |
| St. Petersburg Ladies' Trophy | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Varvara Gracheva | Win | |
| Second Round | Tereza Martincova | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Zarina Diyas | Win | |
| Second Round | Shuai Zhang | Loss |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Emma Raducanu | Win | |
| Second Round | Caroline Garcia | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 3 - Jan. 9 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Storm Sanders | Win | |
| Second Round | Marie Bouzkova | Win | |
| Quarterfinals | Shelby Rogers | Win | |
| Semifinals | Misaki Doi | Win | |
| Final | Ashleigh Barty | Loss |
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