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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Alexander Shevchenko | Win | 6-3, 6-2, 6-2 |
| Second Round | Yu Hsiou Hsu | Win | 7-5, 6-4, 6-4 |
| Third Round | Matteo Arnaldi | Loss | 3-6, 4-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Gael Monfils | Loss | 6-3, 4-6, 3-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Alex De Minaur | Loss | 5-7, 4-6 |
| Abierto de Tenis Mifel | ||
| Surface: Hard | Date: Aug. 1 - Aug. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aleksandar Kovacevic | Loss | 7-5, 6-7 (7-9), 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Tomas Machac | Win | |
| Second Round | Christopher Eubanks | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Miomir Kecmanovic | Win | |
| Second Round | Jordan Thompson | Win | |
| Quarterfinals | Sebastian Korda | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | |
| Second Round | Lucas Pouille | Win | |
| Third Round | Lorenzo Musetti | Loss |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | David Goffin | Win | |
| Quarterfinals | Sebastian Baez | Win | |
| Semifinals | Francisco Cerundolo | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexandre Muller | Win | |
| Third Round | Marton Fucsovics | Win | |
| Fourth Round | Novak Djokovic | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yosuke Watanuki | Win | |
| Third Round | Zhizhen Zhang | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pavel Kotov | Win | |
| Third Round | Lorenzo Musetti | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tung-lin Wu | Win | |
| Third Round | Taro Daniel | Win | |
| Fourth Round | Andrey Rublev | Win | |
| Quarterfinals | Frances Tiafoe | Loss |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Juan Manuel Cerundolo | Win | |
| Second Round | Thiago Monteiro | Win | |
| Quarterfinals | Hugo Dellien | Win | |
| Semifinals | Bernabe Zapata Miralles | Win | |
| Final | Carlos Alcaraz | Win |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Facundo Diaz Acosta | Win | |
| Quarterfinals | Tomas Martin Etcheverry | Win | |
| Semifinals | Juan Pablo Varillas | Win | |
| Final | Carlos Alcaraz | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Luca Van Assche | Win | |
| Second Round | Constant Lestienne | Win | |
| Third Round | Jiri Lehecka | Loss |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | |
| Quarterfinals | Marcos Giron | Win | |
| Semifinals | Jenson Brooksby | Win | |
| Final | Richard Gasquet | Loss |
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