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| Rolex Paris Masters | ||
| Surface: Hard | Date: Oct. 31 - Nov. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Win | 6-7 (2-7), 6-3, 6-4 |
| Second Round | Pablo Carreno Busta | Loss | 6-7 (2-7), 6-2, 4-6 |
| Erste Bank Open 500 | ||
| Surface: Hard | Date: Oct. 24 - Oct. 30 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jurij Rodionov | Win | 6-4, 6-4 |
| Second Round | Taylor Fritz | Win | 6-1, 4-6, 6-3 |
| Quarterfinals | Daniel Evans | Win | 6-3, 6-3 |
| Semifinals | Borna Coric | Win | 7-6 (7-4), 6-0 |
| Final | Daniil Medvedev | Loss | 6-4, 3-6, 2-6 |
| Stockholm Open | ||
| Surface: Hard | Date: Oct. 17 - Oct. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Antoine Bellier | Win | 6-4, 7-5 |
| Quarterfinals | Alex de Minaur | Loss | 2-6, 6-7 (4-7) |
| Rakuten Japan Open | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Steve Johnson | Win | 6-3, 7-6 (7-3) |
| Second Round | Rio Noguchi | Win | 6-3, 6-1 |
| Quarterfinals | Borna Coric | Win | 6-4, 6-3 |
| Semifinals | Taylor Fritz | Loss | 3-6, 7-6 (7-5), 3-6 |
| Eugene Korea Open Tennis Championships | ||
| Surface: Hard | Date: Sep. 26 - Oct. 2 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Win | |
| Quarterfinals | Radu Albot | Win | |
| Semifinals | Jenson Brooksby | Win | |
| Final | Yoshihito Nishioka | Loss |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Marc-Andrea Huesler | Win | 2-6, 6-4, 6-4, 3-6, 6-1 |
| Second Round | Roberto Carballes Baena | Win | 6-4, 4-6, 6-3, 6-2 |
| Third Round | Andrey Rublev | Loss | 4-6, 6-2, 7-6 (7-3), 4-6, 6-7 (7-9) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Grigor Dimitrov | Win | |
| Second Round | Tommy Paul | Win | |
| Third Round | Daniil Medvedev | Loss |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alex De Minaur | Loss |
| Citi Open | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | J.J. Wolf | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Arthur Rinderknech | Win | |
| Second Round | Brandon Nakashima | Loss |
| Mallorca Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benjamin Bonzi | Loss |
| cinch Championships | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Tommy Paul | Loss |
| BOSS OPEN | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Oscar Otte | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Holger Rune | Loss |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 15 - May 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Sonego | Win | |
| Second Round | Nikoloz Basilashvili | Win | |
| Third Round | Rafael Nadal | Win | |
| Quarterfinals | Casper Ruud | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Ugo Humbert | Win | |
| Second Round | Andy Murray | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lloyd Harris | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Davidovich Fokina | Win | |
| Third Round | Reilly Opelka | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Marton Fucsovics | Win | |
| Second Round | Taro Daniel | Win | |
| Quarterfinals | Ricardas Berankis | Win | |
| Semifinals | Jiri Vesely | Loss |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Molcan | Win | |
| Quarterfinals | Arthur Rinderknech | Loss |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jiri Lehecka | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | |
| Second Round | Soon Woo Kwon | Win | |
| Third Round | Reilly Opelka | Win | |
| Fourth Round | Alexander Zverev | Win | |
| Quarterfinals | Rafael Nadal | Loss |
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