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| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | 6-3, 6-4 |
| Third Round | Jan-Lennard Struff |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | 6-3, 7-5 |
| Third Round | Daniil Medvedev | Loss | 2-6, 6-1, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | 7-6 (7-4), 6-1 |
| Third Round | Leonardo Mayer | Win | 6-4, 6-4 |
| Fourth Round | Denis Shapovalov | Loss | 6-4, 3-6, 6-7 (3-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Felix Auger-Aliassime | Loss | 4-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 25 - Mar. 2 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Matthew Ebden | Win | 6-4, 3-6, 6-3 |
| Second Round | Egor Gerasimov | Win | 6-3, 6-1 |
| Quarterfinals | Hubert Hurkacz | Win | 7-6 (7-4), 6-7 (1-7), 6-1 |
| Semifinals | Gael Monfils | Win | 4-6, 7-6 (7-4), 7-6 (7-4) |
| Final | Roger Federer | Loss | 4-6, 4-6 |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 18 - Feb. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hubert Hurkacz | Win | 6-4, 6-2 |
| Quarterfinals | Sergiy Stakhovsky | Win | 6-4, 6-3 |
| Semifinals | David Goffin | Win | 7-6 (7-1), 6-2 |
| Final | Mikhail Kukushkin | Win | 7-5, 7-6 (7-5) |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 11 - Feb. 17 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Damir Dzumhur | Loss | 4-6, 6-1, 5-7 |
| Garanti Koza Sofia Open | ||
| Surface: Hard | Date: Feb. 4 - Feb. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Win | 7-6 (7-5), 6-4 |
| Quarterfinals | Gael Monfils | Loss | 3-6, 6-7 (5-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Matteo Berrettini | Win | 6-7 (3-7), 6-4, 6-3, 7-6(7-4) |
| Second Round | Viktor Troicki | Win | 6-3, 2-6, 6-2, 7-5 |
| Third Round | Nikoloz Basilashvili | Win | 6-3, 3-6, 7-6 (9-7), 6-4 |
| Fourth Round | Roger Federer | Win | 6-7 (11-13), 7-6 (7-3), 7-5, 7-6(7-5) |
| Quarterfinals | Roberto Bautista Agut | Win | 7-5, 4-6, 6-4, 7-6(7-2) |
| Semifinals | Rafael Nadal | Loss | 2-6, 4-6, 0-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guido Andreozzi | Win | 6-3, 6-4 |
| Quarterfinals | Andreas Seppi | Loss | 6-4, 4-6, 4-6 |
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