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| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Andy Murray | Win | 2-6, 7-6 (9-7), 3-6, 6-3, 6-4 |
| Second Round | Adrian Mannarino | Win | 6-3, 6-4, 6-7 (4-7), 6-0 |
| Third Round | Carlos Alcaraz | Loss | 3-6, 6-4, 6-7 (2-7), 6-0, 6-7 (5-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Korda | Win | 7-6 (7-5), 6-3 |
| Third Round | Lorenzo Sonego | Win | 5-7, 6-3, 6-4 |
| Quarterfinals | Felix Auger-Aliassime | Win | 6-2, 5-7, 6-1 |
| Semifinals | Alexander Zverev | Loss | 4-6, 6-3, 6-7 (4-7) |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ugo Humbert | Win | 6-3, 6-7 (13-15), 6-1 |
| Third Round | Karen Khachanov | Win | 6-3, 6-2 |
| Quarterfinals | Casper Ruud | Win | 6-1, 6-4 |
| Semifinals | Reilly Opelka | Loss | 7-6 (7-2), 6-7 (4-7), 4-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 12 - Jul. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominik Koepfer | Win | 7-6 (7-2), 6-3 |
| Quarterfinals | Filip Krajinovic | Loss | 6-3, 1-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Frances Tiafoe | Loss | 4-6, 4-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jeremy Chardy | Win | 7-6 (8-6), 6-3, 6-1 |
| Second Round | Pedro Martinez | Win | 6-3, 6-4, 6-3 |
| Third Round | John Isner | Win | 5-7, 6-3, 7-6 (7-3), 6-1 |
| Fourth Round | Pablo Carreno Busta | Win | 6-3, 6-2, 7-5 |
| Quarterfinals | Daniil Medvedev | Win | 6-3, 7-6 (7-3), 7-5 |
| Semifinals | Alexander Zverev | Win | 6-3, 6-3, 4-6, 4-6, 6-3 |
| Final | Novak Djokovic | Loss | 7-6 (8-6), 6-2, 3-6, 2-6, 4-6 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 17 - May 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tommy Paul | Win | 6-1, 6-4 |
| Quarterfinals | Yoshihito Nishioka | Win | 6-3, 6-4 |
| Semifinals | Lorenzo Musetti | Win | 4-6, 6-3, 6-0 |
| Final | Cameron Norrie | Win | 6-3, 6-3 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marin Cilic | Win | 7-5, 6-2 |
| Third Round | Matteo Berrettini | Win | 7-6 (7-3), 6-2 |
| Quarterfinals | Novak Djokovic | Loss | 6-4, 5-7, 5-7 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benoit Paire | Win | 6-1, 6-2 |
| Third Round | Casper Ruud | Loss | 6-7 (4-7), 4-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Win | 6-0, 6-2 |
| Third Round | Alex De Minaur | Win | 7-5, 6-3 |
| Quarterfinals | Felix Auger-Aliassime | Win | 6-3, 6-3 |
| Semifinals | Jannik Sinner | Win | 6-3, 6-3 |
| Final | Rafael Nadal | Loss | 4-6, 7-6 (8-6), 5-7 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 11 - Apr. 18 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aslan Karatsev | Win | 6-3, 6-4 |
| Third Round | Cristian Garin | Win | 6-3, 6-4 |
| Quarterfinals | Alejandro Davidovich Fokina | Win | 7-5, 0-0 Retired |
| Semifinals | Daniel Evans | Win | 6-2, 6-1 |
| Final | Andrey Rublev | Win | 6-3, 6-3 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Damir Dzumhur | Win | 6-1, 6-4 |
| Third Round | Kei Nishikori | Win | 6-3, 3-6, 6-1 |
| Fourth Round | Lorenzo Sonego | Win | 6-2, 7-6 (7-2) |
| Quarterfinals | Hubert Hurkacz | Loss | 6-2, 3-6, 4-6 |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Mar. 15 - Mar. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 6-3, 6-1 |
| Second Round | John Isner | Win | 6-3, 6-2 |
| Quarterfinals | Felix Auger-Aliassime | Win | 7-5, 4-6, 6-3 |
| Semifinals | Lorenzo Musetti | Win | 6-1, 6-3 |
| Final | Alexander Zverev | Loss | 4-6, 6-7 (3-7) |
| Open 13 Provence | ||
| Surface: Hard | Date: Mar. 8 - Mar. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lucas Pouille | Win | 6-2, 6-3 |
| Quarterfinals | Pierre-Hugues Herbert | Loss | 7-6 (8-6), 4-6, 2-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Egor Gerasimov | Win | 7-6 (7-4), 7-5 |
| Second Round | Hubert Hurkacz | Win | 6-4, 4-6, 7-5 |
| Quarterfinals | Karen Khachanov | Win | 4-6, 6-3, 7-5 |
| Semifinals | Andrey Rublev | Loss | 3-6, 6-7 (2-7) |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Gilles Simon | Win | 6-1, 6-2, 6-1 |
| Second Round | Thanasi Kokkinakis | Win | 6-7 (5-7), 6-4, 6-1, 6-7(5-7), 6-4 |
| Third Round | Mikael Ymer | Win | 6-4, 6-1, 6-1 |
| Fourth Round | Matteo Berrettini | Win | Retired |
| Quarterfinals | Rafael Nadal | Win | 3-6, 2-6, 7-6 (7-4), 6-4, 7-5 |
| Semifinals | Daniil Medvedev | Loss | 4-6, 2-6, 5-7 |
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