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| Astana Open | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sho Shimabukuro | Win | 7-6 (7-5), 6-7 (4-7), 6-1 |
| Quarterfinals | Sebastian Korda | Loss | 4-6, 6-4, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Arthur Fils | Loss | 6-4, 3-6, 7-5, 4-6, 5-7 |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Draper | Win | 7-6 (10-8) Retired |
| Third Round | Max Purcell | Loss | 6-7 (4-7), 6-7 (2-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Frances Tiafoe | Loss | 4-6, 7-6 (9-7), 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexander Zverev | Loss | 4-6, 6-7 (3-7) |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Liam Broady | Win | 6-4, 6-2 |
| Third Round | Gael Monfils | Win | 6-4, 1-6, 6-3 |
| Quarterfinals | J.J. Wolf | Win | 7-5, 6-4 |
| Semifinals | Taylor Fritz | Win | 3-6, 6-3, 6-2 |
| Final | Daniel Evans | Loss | 5-7, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Marton Fucsovics | Loss |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Roberto Carballes Baena | Win | |
| Second Round | Hubert Hurkacz | Win | |
| Quarterfinals | Andrey Rublev | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | |
| Second Round | Alexei Popyrin | Win | |
| Quarterfinals | Alex De Minaur | Win | |
| Semifinals | Emil Ruusuvuori | Win | |
| Final | Jordan Thompson | Win |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Pedro Martinez | Win | |
| Second Round | Hubert Hurkacz | Loss |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Stefano Travaglia | Win | |
| Second Round | Nicolas Jarry | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 30 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Loss |
| Banja Luka Open | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alexei Popyrin | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Loss |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 3 - Apr. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elias Ymer | Win | |
| Quarterfinals | Roberto Carballes Baena | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guido Pella | Win | |
| Third Round | Carlos Alcaraz | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Constant Lestienne | Win | |
| Second Round | Novak Djokovic | Loss |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Quentin Halys | Win | |
| Second Round | Andrey Rublev | Loss |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | |
| Second Round | Alexander Zverev | Win | |
| Quarterfinals | Gijs Brouwer | Win | |
| Semifinals | Jannik Sinner | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Pavel Kotov | Win | |
| Second Round | Botic Van De Zandschulp | Win | |
| Third Round | Stefanos Tsitsipas | Loss |
| Tata Open Maharashtra | ||
| Surface: Hard | Date: Jan. 2 - Jan. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jaume Munar | Win | |
| Second Round | Marco Cecchinato | Win | |
| Quarterfinals | Marin Cilic | Win | |
| Semifinals | Aslan Karatsev | Win | |
| Final | Benjamin Bonzi | Win |
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