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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Michael Mmoh |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcos Giron | Win | 4-6, 6-2, 6-3 |
| Quarterfinals | Ilya Ivashka | Win | 6-1, 6-2 |
| Semifinals | Grigor Dimitrov | Loss | 6-3, 5-7, 6-7 (2-7) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss | 4-6, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Christopher O'Connell | Win | 7-6 (13-11), 6-4 |
| Third Round | Cristian Garin | Win | 6-1, 7-6 (7-4) |
| Fourth Round | Zhizhen Zhang | Loss | 6-3, 6-7 (5-7), 6-7 (8-10) |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 17 - Apr. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | 4-6, 6-3, 6-3 |
| Quarterfinals | Dominic Thiem | Win | 6-3, 6-4 |
| Semifinals | Botic Van De Zandschulp | Loss | 4-6, 6-7 (2-7) |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Stan Wawrinka | Win | 7-6 (12-10), 6-2 |
| Third Round | Jiri Lehecka | Win | 4-6, 6-4, 6-1 |
| Quarterfinals | Stefanos Tsitsipas | Win | 6-2, 6-4 |
| Semifinals | Andrey Rublev | Loss | 7-5, 1-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emilio Nava | Win | 6-4, 6-1 |
| Third Round | Denis Shapovalov | Win | 6-4, 6-4 |
| Fourth Round | Holger Rune | Win | 6-3, 6-4 |
| Quarterfinals | Carlos Alcaraz | Loss | 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ben Shelton | Win | 4-6, 6-4, 6-3 |
| Third Round | Sebastian Baez | Win | 6-1, 6-2 |
| Fourth Round | Marton Fucsovics | Win | 6-4, 6-3 |
| Quarterfinals | Jannik Sinner | Loss | 4-6, 6-4, 4-6 |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | John Isner | Win | 3-6, 6-3, 6-4 |
| Second Round | Denis Shapovalov | Win | 6-4, 6-4 |
| Quarterfinals | Frances Tiafoe | Win | 6-3, 6-4 |
| Semifinals | Tommy Paul | Loss | 3-6, 7-6 (7-2), 6-7 (2-7) |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emilio Gomez | Win | 6-4, 6-3 |
| Quarterfinals | Adrian Mannarino | Win | 7-6 (10-8), 6-4 |
| Semifinals | Mackenzie McDonald | Win | 6-3, 7-6 (8-6) |
| Final | Miomir Kecmanovic | Win | 6-0, 5-7, 6-2 |
| Dallas Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | |
| Quarterfinals | Marcos Giron | Win | |
| Semifinals | Yibing Wu | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Nikoloz Basilashvili | Win | |
| Second Round | Alexei Popyrin | Loss |
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