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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Win | 6-3, 6-4, 6-2 |
| Second Round | Aslan Karatsev | Win | 3-6, 6-3, 7-5, 6-2 |
| Third Round | Alexander Zverev |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniel Altmaier | Win | 3-6, 7-5, 6-3 |
| Third Round | Lorenzo Musetti | Loss | 7-5, 4-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Martin Etcheverry | Win | 6-3, 7-6 (7-5) |
| Third Round | Pedro Cachin | Loss | 1-6, 6-7 (2-7) |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emil Ruusuvuori | Loss | 4-6, 7-6 (7-3), 4-6 |
| Fayez Sarofim & Co. U.S. Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Steve Johnson | Win | 6-2, 6-4 |
| Quarterfinals | Jason Kubler | Win | 6-4, 6-4 |
| Semifinals | Gijs Brouwer | Win | 6-4, 6-1 |
| Final | Tomas Martin Etcheverry | Win | 7-6 (7-1), 7-6 (8-6) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yosuke Watanuki | Win | 6-7 (5-7), 7-6 (7-3), 6-4 |
| Third Round | Lorenzo Sonego | Loss | 3-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcos Giron | Win | 6-2, 6-2 |
| Third Round | Jason Kubler | Win | 6-3, 6-2 |
| Fourth Round | Alejandro Tabilo | Win | 6-4, 6-4 |
| Quarterfinals | Cameron Norrie | Win | 6-4, 6-4 |
| Semifinals | Daniil Medvedev | Loss | 5-7, 6-7 (4-7) |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Yoshihito Nishioka | Win | 7-6 (8-6), 6-4 |
| Second Round | Feliciano Lopez | Win | 6-2, 7-6 (8-6) |
| Quarterfinals | Taylor Fritz | Loss | 3-6, 4-6 |
| Dallas Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | |
| Quarterfinals | J.J. Wolf | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Altmaier | Win | |
| Second Round | Juncheng Shang | Win | |
| Third Round | Karen Khachanov | Loss |
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