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| Chengdu Open | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pavel Kotov |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Aleksandar Vukic | Win | 6-4, 6-4, 6-4 |
| Second Round | Daniel Altmaier | Win | 7-6 (7-1), 3-6, 6-4, 6-3 |
| Third Round | Grigor Dimitrov | Win | 6-7 (2-7), 7-6 (10-8), 6-1, 6-1 |
| Fourth Round | Jannik Sinner | Win | 6-4, 3-6, 6-2, 4-6, 6-3 |
| Quarterfinals | Carlos Alcaraz | Loss | 3-6, 2-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Grigor Dimitrov | Win | 6-2, 6-2 |
| Second Round | Yoshihito Nishioka | Win | 7-5, 6-4 |
| Third Round | Daniil Medvedev | Win | 6-4, 5-7, 6-4 |
| Quarterfinals | Adrian Mannarino | Win | 6-2, 6-3 |
| Semifinals | Novak Djokovic | Loss | 6-7 (5-7), 5-7 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Tallon Griekspoor | Win | 6-4, 7-6 (7-3) |
| Second Round | Alejandro Davidovich Fokina | Loss | 1-6, 2-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Alex Molcan | Win | 6-0, 6-3 |
| Second Round | Maximilian Marterer | Win | 6-3, 7-5 |
| Quarterfinals | Luca Van Assche | Win | 6-3, 6-4 |
| Semifinals | Arthur Fils | Win | 6-2, 6-4 |
| Final | Laslo Djere | Win | 7-5, 6-3 |
| Nordea Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alex Molcan | Win | |
| Second Round | Thiago Monteiro | Win | |
| Quarterfinals | Andrey Rublev | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Gijs Brouwer | Win | |
| Second Round | Yosuke Watanuki | Win | |
| Third Round | Matteo Berrettini | Loss |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Dominic Thiem | Win | |
| Second Round | Denis Shapovalov | Win | |
| Quarterfinals | Nicolas Jarry | Win | |
| Semifinals | Alexander Bublik | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Lloyd Harris | Win | |
| Second Round | Alex Molcan | Win | |
| Third Round | Frances Tiafoe | Win | |
| Fourth Round | Grigor Dimitrov | Win | |
| Quarterfinals | Tomas Martin Etcheverry | Win | |
| Semifinals | Casper Ruud | Loss |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Christopher Eubanks | Win | |
| Quarterfinals | Yibing Wu | Win | |
| Semifinals | Nicolas Jarry | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | David Goffin | Win | |
| Third Round | J.J. Wolf | Win | |
| Fourth Round | Daniil Medvedev | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Carballes Baena | Win | |
| Third Round | Hugo Grenier | Win | |
| Fourth Round | Carlos Alcaraz | Loss |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 17 - Apr. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Christopher O'Connell | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Alexander Bublik | Win | |
| Second Round | Roberto Bautista Agut | Win | |
| Third Round | Daniil Medvedev | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taro Daniel | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Cachin | Win | |
| Third Round | Emil Ruusuvuori | Win | |
| Fourth Round | Daniil Medvedev | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jiri Lehecka | Win | |
| Second Round | Christopher O'Connell | Win | |
| Quarterfinals | Lorenzo Sonego | Win | |
| Semifinals | Andrey Rublev | Loss |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andy Murray | Loss |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | SoonWoo Kwon | Win | |
| Second Round | Tallon Griekspoor | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Juan Pablo Varillas | Win | |
| Second Round | Michael Mmoh | Loss |
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