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| Moselle Open | ||
| Surface: Hard | Date: Sep. 18 - Sep. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Julien Benneteau | Win | 6-4, 2-6, 6-4, 6-2 |
| Second Round | Guido Pella | Win | 3-6, 7-6 (7-5), 6-7 (2-7), 7-6(7-4), 6-3 |
| Third Round | Gael Monfils | Win | 7-5, 5-1 Retired |
| Fourth Round | Andrey Rublev | Loss | 5-7, 6-7 (5-7), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Nick Kyrgios | Loss | 2-6, 3-6 |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Yuichi Sugita | Win | 4-6, 6-1, 6-4 |
| Second Round | Hyeon Chung | Loss | 5-7, 3-6 |
| J. Safra Sarasin Suisse Open Gstaad | ||
| Surface: Clay | Date: Jul. 24 - Jul. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Radu Albot | Win | 2-6, 7-6 (9-7), 7-6 (9-7) |
| Quarterfinals | Robin Haase | Loss | 5-7, 1-6 |
| Plava Laguna Croatia Open Umag | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Attila Balazs | Win | 6-4, 6-7 (7-9), 6-2 |
| Quarterfinals | Ivan Dodig | Loss | 5-7, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Paul-Henri Mathieu | Win | 6-2, 6-2, 6-2 |
| Second Round | Sergiy Stakhovsky | Win | 6-2, 6-4, 3-6, 6-3 |
| Third Round | Horacio Zeballos | Loss | 5-4 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Thomaz Bellucci | Win | 6-7 (5-7), 6-3, 6-4 |
| Second Round | Fernando Verdasco | Win | 3-6, 6-3, 6-2 |
| Third Round | Marin Cilic | Loss | 3-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Karen Khachanov | Win | 6-2, 7-6 (10-8) |
| Second Round | Florian Mayer | Win | 7-6 (7-3), 6-0 |
| Third Round | Milos Raonic | Win | 6-4, 6-2 |
| Quarterfinals | Rafael Nadal | Loss | 6-7 (3-7), 2-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nikoloz Basilashvili | Win | 7-5, 6-0 |
| Third Round | Karen Khachanov | Loss | 7-6 (9-7), 3-6, 4-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Steve Darcis | Win | 6-2, 6-1 |
| Second Round | Nicolas Almagro | Win | 7-5, 6-1 |
| Third Round | Dominic Thiem | Win | 7-6 (7-4), 4-6, 6-3 |
| Quarterfinals | Novak Djokovic | Win | 6-2, 3-6, 7-5 |
| Semifinals | Rafael Nadal | Loss | 3-6, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Darian King | Win | 7-5, 6-1 |
| Third Round | Diego Schwartzman | Win | 4-6, 6-3, 7-5 |
| Fourth Round | Nick Kyrgios | Loss | 6-7 (5-7), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karen Khachanov | Win | 6-4, 3-6, 6-3 |
| Third Round | Albert Ramos-Vinolas | Win | 7-6 (7-3), 6-4 |
| Fourth Round | Pablo Cuevas | Loss | 3-6, 6-3, 3-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Stephane Robert | Win | 6-1, 6-2 |
| Second Round | Sam Querrey | Loss | 2-6, 3-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Andrey Kuznetsov | Win | 6-3, 6-2 |
| Second Round | Robin Haase | Win | 5-7, 6-4, 6-4 |
| Quarterfinals | Grigor Dimitrov | Win | 6-4, 1-6, 6-3 |
| Semifinals | Pierre-Hugues Herbert | Win | 6-1, 6-3 |
| Final | Jo-Wilfried Tsonga | Loss | 6-4, 4-6, 1-6 |
| Garanti Koza Sofia Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Radu Albot | Win | 6-2, 6-7 (7-9), 6-3 |
| Quarterfinals | Steve Darcis | Win | 6-1, 6-3 |
| Semifinals | Roberto Bautista Agut | Win | 5-7, 6-4, 7-6 (7-3) |
| Final | Grigor Dimitrov | Loss | 5-7, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Reilly Opelka | Win | 6-4, 4-6, 6-2, 4-6, 6-4 |
| Second Round | Radek Stepanek | Win | 6-4, 6-0, 6-3 |
| Third Round | Ivo Karlovic | Win | 6-3, 6-2, 6-4 |
| Fourth Round | Dominic Thiem | Win | 5-7, 7-6 (7-4), 6-2, 6-2 |
| Quarterfinals | Grigor Dimitrov | Loss | 3-6, 2-6, 4-6 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Jan. 2 - Jan. 7 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Robin Haase | Win | 7-6 (7-4), 6-2 |
| Second Round | Fernando Verdasco | Loss | 1-6, 6-7 (6-8) |
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