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| Shenzhen Open | ||
| Surface: Hard | Date: Sep. 26 - Oct. 2 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Malek Jaziri |
| Moselle Open | ||
| Surface: Hard | Date: Sep. 19 - Sep. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Win | 6-4, 6-2 |
| Quarterfinals | Nicolas Mahut | Win | 6-3, 6-7 (6-8), 6-4 |
| Semifinals | Lucas Pouille | Loss | 6-7 (6-8), 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Jared Donaldson | Loss | 6-4, 5-7, 4-6, 0-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Nikoloz Basilashvili | Win | 7-5, 6-3 |
| Second Round | Bernard Tomic | Loss | 6-3, 5-7, 4-6 |
| Rogers Cup | ||
| Surface: Hard | Date: Jul. 25 - Jul. 31 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sam Querrey | Win | 6-4, 2-1 Retired |
| Third Round | Gael Monfils | Loss | 6-7 (5-7), 6-2, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Alexander Ward | Win | 6-2, 6-3, 6-2 |
| Second Round | Edouard Roger-Vasselin | Win | 6-4, 6-0, 6-3 |
| Third Round | Denis Istomin | Win | 6-4, 6-3, 2-6, 6-1 |
| Fourth Round | Milos Raonic | Loss | 6-4, 6-3, 4-6, 4-6, 4-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Borna Coric | Win | 7-6 (7-5), 6-7 (3-7), 6-4 |
| Second Round | Sergiy Stakhovsky | Win | 4-6, 7-5, 2-0 Retired |
| Quarterfinals | Roger Federer | Loss | 1-6, 6-7 (10-12) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Gregoire Barrere | Win | 6-3, 6-3, 6-4 |
| Second Round | Carlos Berlocq | Win | 7-5, 6-1, 6-4 |
| Third Round | Nicolas Almagro | Win | 6-2, 4-6, 6-3, 4-6, 6-2 |
| Fourth Round | Ernests Gulbis | Win | 4-6, 6-2, 6-2, 6-3 |
| Quarterfinals | Dominic Thiem | Loss | 6-4, 6-7 (7-9), 4-6, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Leonardo Mayer | Win | 2-6, 7-6 (10-8), 6-3 |
| Second Round | Jack Sock | Win | 6-4, 6-4 |
| Third Round | Tomas Berdych | Win | 6-0, 6-0 |
| Quarterfinals | Andy Murray | Loss | 1-6, 5-7 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: Apr. 30 - May 8 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Lucas Pouille | Loss | 6-7 (4-7), 6-2, 6-7 (7-9) |
| BMW Open by FWU AG | ||
| Surface: Red Clay | Date: Apr. 25 - May 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Victor Estrella Burgos | Win | 5-7, 6-3, 6-2 |
| Quarterfinals | Alexander Zverev | Loss | 3-6, 6-4, 3-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Feliciano Lopez | Win | 7-5, 6-0 |
| Second Round | Fernando Verdasco | Win | 7-6 (7-2), 2-6, 7-6 (7-1) |
| Third Round | Marcel Granollers | Loss | 6-7 (1-7), 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcel Granollers | Win | 6-4, 6-4 |
| Third Round | Viktor Troicki | Win | 6-1, 6-1 |
| Fourth Round | Horacio Zeballos | Win | 7-5, 6-3 |
| Quarterfinals | Gilles Simon | Win | 3-6, 6-2, 6-1 |
| Semifinals | Novak Djokovic | Loss | 6-7 (5-7), 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Frances Tiafoe | Win | 3-6, 6-3, 7-6 (7-2) |
| Third Round | Guido Pella | Win | 4-6, 6-3, 6-2 |
| Fourth Round | Stan Wawrinka | Win | 6-3, 5-7, 7-6 (7-5) |
| Quarterfinals | Marin Cilic | Win | 7-6 (7-4), 6-2 |
| Semifinals | Milos Raonic | Loss | 3-6, 6-3, 3-6 |
| Open 13 | ||
| Surface: Hard | Date: Feb. 15 - Feb. 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Hyeon Chung | Win | 6-3, 6-1 |
| Second Round | Mischa Zverev | Win | 6-1, 2-0 Retired |
| Quarterfinals | Tomas Berdych | Loss | 3-6, 4-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 8 - Feb. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Marcos Baghdatis | Loss | 1-6, 7-5, 6-7 (5-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Sergiy Stakhovsky | Win | 3-6, 6-3, 6-4, 6-4 |
| Second Round | Damir Dzumhur | Win | 6-4, 0-6, 6-4, 6-2 |
| Third Round | Dominic Thiem | Win | 6-1, 3-6, 7-6 (7-2), 7-5 |
| Fourth Round | Roger Federer | Loss | 2-6, 1-6, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 2 - Jan. 10 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Thomaz Bellucci | Win | 6-4, 6-4 |
| Second Round | Lucas Pouille | Loss | 6-7 (5-7), 6-4, 3-6 |
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