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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Denis Istomin | Win | 4-6, 7-6 (7-4), 7-5, 6-7(3-7), 7-5 |
| Second Round | Nicolas Mahut | Loss | 6-4, 4-6, 6-4, 3-6, 0-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mikhail Youzhny | Win | 6-2, 3-6, 6-3 |
| Second Round | Gilles Muller | Win | 5-7, 6-4, 6-4 |
| Third Round | Rafael Nadal | Loss | 6-7 (1-7), 2-6 |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Robin Haase | Loss | 3-6, 3-6 |
| Abierto Mexicano de Tenis Mifel presentado por Cinemex | ||
| Surface: Hard | Date: Jul. 31 - Aug. 5 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Fritz | Loss | 6-7 (5-7), 4-6 |
| German Tennis Championships 2017 | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Leonardo Mayer | Loss | 7-6 (7-3), 3-6, 6-7 (4-7) |
| SkiStar Swedish Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thiago Monteiro | Win | 3-6, 6-4, 6-3 |
| Quarterfinals | Fernando Verdasco | Loss | 3-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 25 |
| Round | Opponent | W / L | Result |
| First Round | Jordan Thompson | Win | 6-4, 6-4, 7-6 (7-4) |
| Second Round | Andrey Rublev | Win | 7-5, 6-7 (6-8), 4-6, 6-3, 6-4 |
| Third Round | Milos Raonic | Loss | 6-7 (3-7), 4-6, 5-7 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Andrey Rublev | Loss | 7-6 (7-1), 5-7, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Marius Copil | Win | 6-7 (7-9), 6-1, 6-4, 6-2 |
| Second Round | Benjamin Bonzi | Win | 6-2, 6-1, 6-1 |
| Third Round | Lucas Pouille | Win | 6-2, 3-6, 5-7, 6-2, 6-1 |
| Fourth Round | Novak Djokovic | Loss | 6-7 (5-7), 1-6, 3-6 |
| Banque Eric Sturdza Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrey Kuznetsov | Loss | 5-7, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | John Isner | Loss | 7-6 (7-4), 6-7 (4-7), 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Diego Schwartzman | Loss | 1-6, 3-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Casper Ruud | Win | 7-6 (8-6), 6-4 |
| Third Round | Roberto Bautista Agut | Win | 6-2, 3-6, 6-4 |
| Quarterfinals | Andy Murray | Loss | 6-2, 4-6, 6-7 (4-7) |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Renzo Olivo | Win | 6-2, 6-3 |
| Second Round | Carlos Berlocq | Win | 6-2, 6-2 |
| Third Round | Andy Murray | Win | 2-6, 6-2, 7-5 |
| Quarterfinals | Marin Cilic | Win | 6-2, 6-7 (5-7), 6-2 |
| Semifinals | Lucas Pouille | Win | 6-3, 5-7, 6-1 |
| Final | Rafael Nadal | Loss | 1-6, 3-6 |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 10 - Apr. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laslo Djere | Win | 6-7 (4-7), 6-1, 6-4 |
| Quarterfinals | Borna Coric | Loss | 6-4, 4-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Vesely | Loss | 6-7 (5-7), 6-4, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Damir Dzumhur | Win | 6-4, 5-7, 7-5 |
| Third Round | David Goffin | Loss | 6-7 (3-7), 4-6 |
| Brasil Open | ||
| Surface: Clay | Date: Feb. 27 - Mar. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gastao Elias | Win | 6-4, 7-6 (7-5) |
| Quarterfinals | Guido Pella | Win | 6-4, 3-6, 6-4 |
| Semifinals | Joao Sousa | Win | 6-7 (5-7), 7-5, 6-2 |
| Final | Pablo Cuevas | Loss | 7-6 (7-3), 4-6, 4-6 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Stephane Robert | Win | 6-2, 6-0 |
| Second Round | Fabio Fognini | Win | 6-2, 6-3 |
| Quarterfinals | Nicolas Kicker | Win | 6-2, 6-3 |
| Semifinals | Dominic Thiem | Loss | 1-6, 4-6 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Guido Pella | Win | 6-7 (8-10), 6-4, 7-6 (8-6) |
| Second Round | Leonardo Mayer | Win | 6-7 (4-7), 7-6 (7-3), 1-0 Retired |
| Quarterfinals | Pablo Carreno Busta | Loss | 3-6, 6-4, 4-6 |
| Ecuador Open Quito | ||
| Surface: Clay | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Falla | Win | 6-2, 7-5 |
| Quarterfinals | Roberto Carballes Baena | Win | 7-5, 4-6, 6-2 |
| Semifinals | Paolo Lorenzi | Loss | 1-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Lukas Lacko | Loss | 6-4, 5-7, 6-1, 4-6, 3-6 |
| Aircel Chennai Open | ||
| Surface: Hard | Date: Jan. 2 - Jan. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Steve Darcis | Win | 6-2, 6-0 |
| Quarterfinals | Dudi Sela | Loss | 5-7, 4-6 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 2 - Jan. 14 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Joao Sousa | Loss | 1-6, 5-7 |
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