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| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Loss | 6-7 (2-7), 4-6 |
| Mutua Madrid Open | ||
| Surface: Clay | Date: May 4 - May 12 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Nikolay Davydenko | Win | 7-5, 7-6 (7-5) |
| Second Round | Fernando Verdasco | Loss | 4-6, 6-2, 6-7 (7-9) |
| Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Edouard Roger-Vasselin | Win | 6-4, 6-2 |
| Third Round | Ernests Gulbis | Win | 6-2, 7-6 (8-6) |
| Quarterfinals | Tommy Robredo | Win | 6-7 (5-7), 6-3, 7-6 (7-2) |
| Semifinals | Rafael Nadal | Loss | 4-6, 0-6 |
| Tennis Masters Monte-Carlo | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Julien Benneteau | Win | 6-1, 6-4 |
| Second Round | Jarkko Nieminen | Loss | 3-6, 6-1, 6-7 (3-7) |
| Miami Masters | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guillaume Rufin | Win | 6-2, 6-4 |
| Third Round | Sam Querrey | Loss | Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Michael Llodra | Win | Retired |
| Third Round | Marin Cilic | Win | 3-6, 6-4, 6-3 |
| Fourth Round | Jo-Wilfried Tsonga | Loss | 6-4, 5-7, 4-6 |
| U.S. National Indoor Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jack Sock | Loss | 3-6, 7-5, 5-7 |
| SAP Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Michael Russell | Win | 6-2, 7-5 |
| Quarterfinals | Denis Istomin | Win | 7-6 (7-0), 6-3 |
| Semifinals | Sam Querrey | Win | 6-4, 6-2 |
| Final | Tommy Haas | Win | 6-4, 6-3 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 13 - Jan. 27 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Jan Hajek | Win | 3-6, 6-1, 6-2, 7-6(7-0) |
| Second Round | Lukas Rosol | Win | 7-6 (7-2), 6-2, 6-3 |
| Third Round | Philipp Kohlschreiber | Win | 7-6 (7-4), 6-3, 6-4 |
| Fourth Round | Roger Federer | Loss | 4-6, 6-7 (4-7), 2-6 |
| Brisbane International | ||
| Surface: Hard | Date: Dec. 29 - Jan. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Grigor Dimitrov | Loss | 3-6, 4-6 |
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