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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Benjamin Becker | Win | 6-1, 6-1, 3-6, 6-3 |
| Second Round | Karen Khachanov | Win | 6-4, 4-6, 6-4, 6-3 |
| Third Round | Nicolas Mahut | Win | 4-6, 6-1, 6-2, 6-2 |
| Fourth Round | Ivo Karlovic | Win | 6-3, 6-4, 7-6 (7-4) |
| Quarterfinals | Andy Murray | Win | 1-6, 6-4, 4-6, 6-1, 7-5 |
| Semifinals | Stan Wawrinka | Loss | 6-4, 5-7, 4-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Youzhny | Win | 6-3, 6-2 |
| Third Round | Bernard Tomic | Loss | 6-7 (1-7), 6-7 (5-7) |
| Rogers Cup | ||
| Surface: Hard | Date: Jul. 25 - Jul. 31 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dennis Novikov | Win | 6-4, 7-5 |
| Third Round | Rajeev Ram | Win | 6-3, 6-4 |
| Quarterfinals | Grigor Dimitrov | Win | 6-3, 3-6, 6-2 |
| Semifinals | Stan Wawrinka | Win | 7-6 (8-6), 6-1 |
| Final | Novak Djokovic | Loss | 3-6, 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Sam Groth | Win | 6-4, 6-3, 7-5 |
| Second Round | Julien Benneteau | Win | 4-6, 6-4, 6-4, 6-2 |
| Third Round | Andrey Kuznetsov | Win | 7-5, 6-3, 7-5 |
| Fourth Round | Marin Cilic | Loss | 1-6, 1-5 Retired |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Lucas Pouille | Win | 6-7 (5-7), 6-1, 6-4 |
| Second Round | Florian Mayer | Loss | Retired |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Simone Bolelli | Win | 6-1, 7-5, 6-3 |
| Second Round | Andrey Kuznetsov | Win | 6-3, 6-3, 6-3 |
| Third Round | Fernando Verdasco | Win | 6-3, 6-4, 3-6, 2-6, 6-4 |
| Fourth Round | Richard Gasquet | Loss | 4-6, 2-6, 6-4, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktor Troicki | Win | 5-7, 6-2, 6-3 |
| Third Round | Richard Gasquet | Win | 6-1, 6-4 |
| Quarterfinals | Dominic Thiem | Win | 6-3, 7-5 |
| Semifinals | Novak Djokovic | Loss | 6-2, 4-6, 6-7 (5-7) |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: Apr. 30 - May 8 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fabio Fognini | Win | 6-2, 3-6, 7-5 |
| Third Round | Richard Gasquet | Win | 6-4, 7-5 |
| Quarterfinals | Nick Kyrgios | Win | 6-7 (6-8), 7-6 (7-1), 6-3 |
| Semifinals | Novak Djokovic | Loss | 3-6, 6-7 (4-7) |
| Barcelona Open BancSabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thiemo de Bakker | Win | 6-4, 6-2 |
| Third Round | Jeremy Chardy | Win | 6-3, 7-5 |
| Quarterfinals | Alexandr Dolgopolov | Win | 7-5, 6-0 |
| Semifinals | Benoit Paire | Win | 6-3, 6-2 |
| Final | Rafael Nadal | Loss | 4-6, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pierre-Hugues Herbert | Win | 6-2, 7-6 (7-4) |
| Third Round | Alexandr Dolgopolov | Win | 6-2, 6-2 |
| Fourth Round | Roberto Bautista Agut | Win | 6-2, 6-4 |
| Quarterfinals | Gael Monfils | Win | 4-6, 6-3, 7-6 (7-3) |
| Semifinals | Nick Kyrgios | Win | 6-3, 7-5 |
| Final | Novak Djokovic | Loss | 3-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | 6-3, 6-3 |
| Third Round | Steve Johnson | Win | 7-6 (8-6), 7-6 (7-5) |
| Fourth Round | John Isner | Win | 1-6, 7-6 (7-2), 7-6 (7-5) |
| Quarterfinals | Rafael Nadal | Loss | 4-6, 3-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 22 - Feb. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Thiemo de Bakker | Win | 6-0, 6-3 |
| Second Round | Sam Querrey | Loss | 4-6, 3-6 |
| Memphis Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ryan Harrison | Win | 6-2, 7-5 |
| Quarterfinals | Mikhail Kukushkin | Win | 6-2, 6-4 |
| Semifinals | Sam Querrey | Win | 3-6, 6-3, 6-3 |
| Final | Taylor Fritz | Win | 6-4, 6-4 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Win | 6-4, 6-3, 6-3 |
| Second Round | Austin Krajicek | Win | 6-3, 7-6 (7-5), 6-3 |
| Third Round | Guillermo Garcia-Lopez | Win | 7-5, 2-6, 6-3, 6-4 |
| Fourth Round | Jo-Wilfried Tsonga | Win | 6-4, 6-2, 6-4 |
| Quarterfinals | Novak Djokovic | Loss | 3-6, 2-6, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 2 - Jan. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | 6-3, 6-4 |
| Quarterfinals | Bernard Tomic | Loss | 3-6, 6-1, 3-6 |
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