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| Barcelona Open BancSabadell | ||
| Surface: Clay | Date: Apr. 21 - Apr. 27 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| Sony Open Tennis | ||
| Surface: Hard | Date: Mar. 18 - Mar. 30 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marinko Matosevic | Win | 6-4, 6-1 |
| Third Round | Grigor Dimitrov | Win | 7-6 (7-1), 7-5 |
| Fourth Round | David Ferrer | Win | 7-6 (9-7), 2-6, 7-6 (11-9) |
| Quarterfinals | Roger Federer | Win | 3-6, 7-5, 6-4 |
| Semifinals | Novak Djokovic | Loss | Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 5 - Mar. 16 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Santiago Giraldo | Win | 6-1, 6-3 |
| Third Round | Tommy Haas | Loss | 6-7 (3-7), 2-6 |
| Delray Beach Open by The Venetian Las Vegas | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Gastao Elias | Win | 6-1, 5-7, 6-2 |
| Second Round | Teymuraz Gabashvili | Loss | 2-4 Retired |
| U.S. National Indoor Tennis Championships | ||
| Surface: Hard | Date: Feb. 10 - Feb. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benjamin Becker | Win | 6-4, 6-4 |
| Quarterfinals | Alex Bogomolov Jr. | Win | 3-6, 6-3, 6-2 |
| Semifinals | Michael Russell | Win | 6-3, 6-2 |
| Final | Ivo Karlovic | Win | 6-4, 7-6 (7-0) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 12 - Jan. 26 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Marinko Matosevic | Win | 6-3, 5-7, 6-2, 4-6, 6-2 |
| Second Round | Dusan Lajovic | Win | 6-1, 6-1, 7-6 (7-3) |
| Third Round | Donald Young | Win | 7-5, 6-1, 6-0 |
| Fourth Round | Rafael Nadal | Loss | 6-7 (3-7), 5-7, 6-7 (3-7) |
| Brisbane Interantional presented by Suncorp | ||
| Surface: Hard | Date: Dec. 28 - Jan. 5 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matthew Ebden | Win | 6-2, 6-4 |
| Quarterfinals | Marin Cilic | Win | 6-4, 5-7, 6-2 |
| Semifinals | Lleyton Hewitt | Loss | 7-5, 4-6, 3-6 |
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