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| Citi Open | ||
| Surface: Hard | Date: Jul. 28 - Aug. 3 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sam Querrey | Win | 6-4, 5-7, 6-4 |
| Third Round | Lukas Lacko | Win | 6-2, 2-6, 6-3 |
| Quarterfinals | Richard Gasquet |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 23 - Jul. 6 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Kenny De Schepper | Win | 6-4, 7-6 (7-5), 7-5 |
| Second Round | Denis Kudla | Win | 6-3, 6-2, 6-1 |
| Third Round | Simone Bolelli | Win | 3-6, 6-3, 4-6, 7-6(7-4), 6-4 |
| Fourth Round | Milos Raonic | Loss | 6-4, 1-6, 6-7 (4-7), 3-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 9 - Jun. 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gael Monfils | Win | 6-1, 3-6, 6-3 |
| Quarterfinals | Steve Johnson | Win | 6-1, 7-6 (7-4) |
| Semifinals | Roger Federer | Loss | 3-6, 6-7 (4-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 25 - Jun. 8 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Martin Klizan | Loss | 6-7 (4-7), 1-6, 2-6 |
| Mutua Madrilena Madrid Open | ||
| Surface: Red Clay | Date: May 3 - May 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Ivan Dodig | Win | 6-4, 6-4 |
| Second Round | Guillermo Garcia-Lopez | Win | 6-3, 6-1 |
| Third Round | Milos Raonic | Win | 7-6 (7-5), 7-6 (7-5) |
| Quarterfinals | Feliciano Lopez | Win | 6-4, 6-4 |
| Semifinals | David Ferrer | Win | 7-6 (7-5), 5-7, 6-3 |
| Final | Rafael Nadal | Loss | 6-2, 4-6, 0-3 Retired |
| Barcelona Open BancSabadell | ||
| Surface: Clay | Date: Apr. 21 - Apr. 27 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Bautista Agut | Win | 6-1, 4-6, 6-3 |
| Third Round | Andrey Golubev | Win | 6-0, 6-4 |
| Quarterfinals | Marin Cilic | Win | 6-1, 6-3 |
| Semifinals | Ernests Gulbis | Win | 6-2, 6-4 |
| Final | Santiago Giraldo | Win | 6-2, 6-2 |
| Sony Open Tennis | ||
| Surface: Hard | Date: Mar. 18 - Mar. 30 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marinko Matosevic | Win | 6-4, 6-1 |
| Third Round | Grigor Dimitrov | Win | 7-6 (7-1), 7-5 |
| Fourth Round | David Ferrer | Win | 7-6 (9-7), 2-6, 7-6 (11-9) |
| Quarterfinals | Roger Federer | Win | 3-6, 7-5, 6-4 |
| Semifinals | Novak Djokovic | Loss | Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 5 - Mar. 16 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Santiago Giraldo | Win | 6-1, 6-3 |
| Third Round | Tommy Haas | Loss | 6-7 (3-7), 2-6 |
| Delray Beach Open by The Venetian Las Vegas | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Gastao Elias | Win | 6-1, 5-7, 6-2 |
| Second Round | Teymuraz Gabashvili | Loss | 2-4 Retired |
| U.S. National Indoor Tennis Championships | ||
| Surface: Hard | Date: Feb. 10 - Feb. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benjamin Becker | Win | 6-4, 6-4 |
| Quarterfinals | Alex Bogomolov Jr. | Win | 3-6, 6-3, 6-2 |
| Semifinals | Michael Russell | Win | 6-3, 6-2 |
| Final | Ivo Karlovic | Win | 6-4, 7-6 (7-0) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 13 - Jan. 26 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Marinko Matosevic | Win | 6-3, 5-7, 6-2, 4-6, 6-2 |
| Second Round | Dusan Lajovic | Win | 6-1, 6-1, 7-6 (7-3) |
| Third Round | Donald Young | Win | 7-5, 6-1, 6-0 |
| Fourth Round | Rafael Nadal | Loss | 6-7 (3-7), 5-7, 6-7 (3-7) |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 29 - Jan. 5 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matthew Ebden | Win | 6-2, 6-4 |
| Quarterfinals | Marin Cilic | Win | 6-4, 5-7, 6-2 |
| Semifinals | Lleyton Hewitt | Loss | 7-5, 4-6, 3-6 |
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