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| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gael Monfils | Loss | 7-6 (7-4), 5-7, 6-7 (6-8) |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Donald Young | Win | 6-3, 4-6, 7-6 (7-5) |
| Third Round | Juan Martin Del Potro | Win | 6-4, 7-5 |
| Quarterfinals | Tommy Paul | Win | 3-6, 7-6 (10-8), 6-4 |
| Semifinals | Alexander Zverev | Loss | 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Marco Cecchinato | Win | 6-2, 6-2, 6-0 |
| Second Round | Sergiy Stakhovsky | Win | 6-4, 6-7 (7-9), 6-1, 7-6(8-6) |
| Third Round | Roberto Bautista Agut | Loss | 4-6, 6-7 (3-7), 6-3, 3-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Win | 6-7 (7-9), 6-3, 6-4 |
| Second Round | Karen Khachanov | Loss | 2-3 Retired |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Thanasi Kokkinakis | Win | 4-6, 6-1, 6-4, 6-4 |
| Second Round | Jeremy Chardy | Win | 6-3, 6-0, 7-6 (7-5) |
| Third Round | Hyeon Chung | Win | 7-5, 6-4, 6-7 (4-7), 0-6, 6-4 |
| Fourth Round | Fernando Verdasco | Win | 0-6, 6-4, 6-4, 6-0 |
| Quarterfinals | Andy Murray | Loss | 6-2, 1-6, 6-7 (0-7), 1-6 |
| Banque Eric Sturdza Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | 6-4, 6-3 |
| Quarterfinals | Kevin Anderson | Win | 2-6, 6-4, 7-6 (8-6) |
| Semifinals | Mischa Zverev | Loss | 4-6, 6-3, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | David Ferrer | Win | 7-5, 6-2 |
| Third Round | Juan Martin Del Potro | Loss | 6-7 (4-7), 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Diego Schwartzman | Win | 1-6, 6-0, 6-4 |
| Third Round | David Ferrer | Win | 6-4, 6-3 |
| Quarterfinals | Novak Djokovic | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kevin Anderson | Win | 6-4, 6-3 |
| Third Round | Fernando Verdasco | Win | 7-6 (7-2), 6-7 (5-7), 6-1 |
| Fourth Round | Federico Delbonis | Win | 6-3, 4-6, 6-3 |
| Quarterfinals | Fabio Fognini | Loss | 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniel Evans | Win | 6-3, 6-4 |
| Third Round | Gilles Muller | Win | 6-2, 6-2 |
| Fourth Round | Donald Young | Win | 6-2, 6-4 |
| Quarterfinals | Jack Sock | Loss | 3-6, 6-2, 2-6 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Thomaz Bellucci | Loss | 4-6, 3-6 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Diego Schwartzman | Win | 5-7, 6-2, 6-2 |
| Quarterfinals | Joao Sousa | Win | 6-1, 6-4 |
| Semifinals | Carlos Berlocq | Win | 4-6, 6-4, 6-3 |
| Final | Alexandr Dolgopolov | Loss | 6-7 (4-7), 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Andrey Kuznetsov | Win | 5-7, 6-1, 6-4, 6-7(6-8), 6-2 |
| Second Round | Jeremy Chardy | Win | 6-3, 6-4, 6-3 |
| Third Round | Lukas Lacko | Win | 6-4, 6-4, 6-4 |
| Fourth Round | Roger Federer | Loss | 7-6 (7-4), 4-6, 1-6, 6-4, 3-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jared Donaldson | Win | 4-6, 6-4, 6-3 |
| Quarterfinals | Jordan Thompson | Win | 6-1, 6-1 |
| Semifinals | Stan Wawrinka | Win | 7-6 (7-3), 6-3 |
| Final | Grigor Dimitrov | Loss | 2-6, 6-2, 3-6 |
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