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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Rogerio Dutra Silva | Win | 6-4, 7-5, 6-1 |
| Second Round | Sergiy Stakhovsky | Win | 6-1, 6-2, 6-3 |
| Third Round | Jack Sock | Loss | 4-6, 3-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Viktor Troicki | Win | 6-3, 6-4 |
| Second Round | Fernando Verdasco | Win | 6-3, 6-1 |
| Third Round | Tomas Berdych | Win | 6-3, 4-6, 6-4 |
| Quarterfinals | Borna Coric | Win | 6-2, 0-0 Retired |
| Semifinals | Grigor Dimitrov | Win | 4-6, 6-3, 7-5 |
| Final | Andy Murray | Win | 6-4, 7-5 |
| Rogers Cup | ||
| Surface: Hard | Date: Jul. 25 - Jul. 31 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ivo Karlovic | Loss | 4-6, 6-7 (3-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Brian Baker | Win | 6-3, 7-5, 6-3 |
| Second Round | Sergiy Stakhovsky | Win | 6-2, 6-7 (6-8), 6-4, 6-4 |
| Third Round | Lukas Lacko | Win | 6-3, 6-3, 6-4 |
| Fourth Round | Kei Nishikori | Win | 6-1, 5-1 Retired |
| Quarterfinals | Roger Federer | Loss | 7-6 (7-4), 6-4, 3-6, 6-7 (9-11), 3-6 |
| AEGON Championships | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Feliciano Lopez | Win | 4-6, 6-3, 6-4 |
| Second Round | Janko Tipsarevic | Win | 6-4, 6-2 |
| Quarterfinals | Steve Johnson | Win | 6-7 (3-7), 6-3, 6-4 |
| Semifinals | Andy Murray | Loss | 3-6, 6-4, 3-6 |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 6 - Jun. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Radek Stepanek | Loss | 6-7 (4-7), 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Marco Trungelliti | Loss | 6-7 (4-7), 6-3, 4-6, 2-6 |
| Geneva Open | ||
| Surface: Clay | Date: May 15 - May 22 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ernests Gulbis | Win | 6-4, 7-6 (7-5) |
| Quarterfinals | Federico Delbonis | Win | 6-4, 6-3 |
| Semifinals | David Ferrer | Win | 7-5, 7-5 |
| Final | Stan Wawrinka | Loss | 4-6, 6-7 (11-13) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Win | 6-4, 6-1 |
| Third Round | Gilles Simon | Loss | 3-6, 7-6 (7-4), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ryan Harrison | Win | 6-4, 6-3 |
| Third Round | Leonardo Mayer | Win | 6-4, 6-3 |
| Fourth Round | Richard Gasquet | Win | 7-5, 5-7, 6-2 |
| Quarterfinals | David Goffin | Loss | 6-7 (4-7), 2-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 22 - Feb. 28 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Ryan Harrison | Loss | 3-6, 6-3, 2-6 |
| Open 13 | ||
| Surface: Hard | Date: Feb. 15 - Feb. 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Robin Haase | Win | 4-6, 6-3, 7-5 |
| Quarterfinals | Andrey Kuznetsov | Win | 6-3, 6-4 |
| Semifinals | Benoit Paire | Win | 6-2, 6-7 (3-7), 6-3 |
| Final | Nick Kyrgios | Loss | 2-6, 6-7 (3-7) |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 8 - Feb. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Denis Istomin | Win | 7-6 (7-5), 6-4 |
| Second Round | Gilles Muller | Win | 7-6 (7-2), 7-6 (9-7) |
| Quarterfinals | Philipp Kohlschreiber | Loss | 6-3, 3-6, 4-6 |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 1 - Feb. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Zverev | Loss | 6-7 (4-7), 6-7 (1-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Thiemo de Bakker | Win | 6-7 (4-7), 7-5, 6-2, 6-4 |
| Second Round | Albert Ramos-Vinolas | Win | 6-4, 6-3, 7-6 (7-4) |
| Third Round | Roberto Bautista Agut | Loss | 4-6, 6-7 (5-7), 5-7 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 2 - Jan. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hyeon Chung | Win | 7-5, 7-6 (7-3) |
| Quarterfinals | Dominic Thiem | Loss | 6-2, 6-7 (4-7), 4-6 |
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