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| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Martin Klizan | Win | 6-3, 6-2, 7-6 (8-6) |
| Second Round | Cedrik-Marcel Stebe | Win | 4-6, 6-3, 7-5, 6-3 |
| Third Round | John Isner | Win | 7-5, 3-6, 7-6 (8-6), 6-4 |
| Fourth Round | Rafael Nadal | Loss | 3-6, 6-3, 1-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Radu Albot | Loss | 4-6, 6-7 (6-8) |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bradley Klahn | Win | 6-3, 7-6 (9-7) |
| Second Round | John Millman | Win | 6-3, 6-4 |
| Third Round | Dominic Thiem | Loss | 6-7 (7-9), 4-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marius Copil | Win | 7-6 (7-4), 7-6 (7-4) |
| Third Round | Felix Auger-Aliassime | Win | 6-3, 6-4 |
| Quarterfinals | Daniil Medvedev | Loss | 4-6, 6-7 (7-9) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Adrian Mannarino | Win | 7-6 (8-6), 7-6 (7-4), 6-3 |
| Second Round | Joao Sousa | Loss | 4-6, 4-6, 4-6 |
| Fever-Tree Championships | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Cristian Garin | Win | 6-1, 7-6 (7-5) |
| Second Round | Diego Schwartzman | Loss | 4-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Thomas Fabbiano | Win | 6-3, 7-5, 6-1 |
| Second Round | Grigor Dimitrov | Loss | 7-6 (7-3), 4-6, 6-4, 6-7 (2-7), 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Basso | Win | 6-1, 7-5 |
| Second Round | Jan-Lennard Struff | Loss | 2-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Martin Klizan | Win | 6-4, 2-6, 7-6 (7-0) |
| Second Round | Jan-Lennard Struff | Win | 4-6, 6-3, 6-4 |
| Third Round | Laslo Djere | Win | 4-6, 6-3, 6-2 |
| Quarterfinals | Novak Djokovic | Loss | Retired |
| Gazprom Hungarian Open | ||
| Surface: Red Clay | Date: Apr. 22 - Apr. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pablo Cuevas | Loss | 7-5, 6-7 (6-8), 6-7 (3-7) |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guido Pella | Loss | 3-6, 7-5, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrey Rublev | Loss | 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Win | 6-3, 6-4 |
| Third Round | Denis Shapovalov | Loss | 4-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 25 - Mar. 2 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Gael Monfils | Loss | 3-6, 6-4, 0-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bernard Tomic | Win | 6-2, 6-4, 7-6 (7-3) |
| Second Round | Mackenzie McDonald | Win | 7-5, 6-7 (9-11), 6-4, 6-4 |
| Third Round | Fernando Verdasco | Win | 4-6, 3-6, 6-1, 7-6(10-8), 6-3 |
| Fourth Round | Roberto Bautista Agut | Loss | 7-6 (8-6), 3-6, 2-6, 6-4, 4-6 |
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