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| St. Petersburg Open | ||
| Surface: Hard | Date: Sep. 19 - Sep. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lukas Rosol | Win | 6-3, 6-1 |
| Quarterfinals | Viktor Troicki | Win | 7-5, 6-2 |
| Semifinals | Roberto Bautista Agut | Win | 7-6 (10-8), 6-2 |
| Final | Alexander Zverev | Loss | 2-6, 6-3, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Win | 7-6 (7-4), 6-4, 6-4 |
| Second Round | Alessandro Giannessi | Win | 6-1, 7-6 (7-4), 7-5 |
| Third Round | Daniel Evans | Win | 4-6, 6-3, 6-7 (6-8), 7-6(10-8), 6-2 |
| Fourth Round | Illya Marchenko | Win | 6-4, 6-1, 6-7 (5-7), 6-3 |
| Quarterfinals | Juan Martin Del Potro | Win | 7-6 (7-5), 4-6, 6-3, 6-2 |
| Semifinals | Kei Nishikori | Win | 4-6, 7-5, 6-4, 6-2 |
| Final | Novak Djokovic | Win | 6-7 (1-7), 6-4, 7-5, 6-3 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jared Donaldson | Win | 2-6, 6-3, 6-4 |
| Third Round | Grigor Dimitrov | Loss | 4-6, 4-6 |
| Rogers Cup | ||
| Surface: Hard | Date: Jul. 25 - Jul. 31 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Youzhny | Win | 7-6 (7-3), 7-6 (10-8) |
| Third Round | Jack Sock | Win | 7-6 (7-3), 6-2 |
| Quarterfinals | Kevin Anderson | Win | 6-1, 6-3 |
| Semifinals | Kei Nishikori | Loss | 6-7 (6-8), 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Taylor Fritz | Win | 7-6 (7-4), 6-1, 6-7 (2-7), 6-4 |
| Second Round | Juan Martin del Potro | Loss | 6-3, 3-6, 6-7 (2-7), 3-6 |
| AEGON Championships | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Loss | 2-6, 6-7 (3-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Lukas Rosol | Win | 4-6, 6-1, 3-6, 6-3, 6-4 |
| Second Round | Taro Daniel | Win | 7-6 (9-7), 6-3, 6-4 |
| Third Round | Jeremy Chardy | Win | 6-4, 6-3, 7-5 |
| Fourth Round | Viktor Troicki | Win | 7-6 (7-5), 6-7 (7-9), 6-3, 6-2 |
| Quarterfinals | Albert Ramos-Vinolas | Win | 6-2, 6-1, 7-6 (9-7) |
| Semifinals | Andy Murray | Loss | 4-6, 2-6, 6-4, 2-6 |
| Geneva Open | ||
| Surface: Clay | Date: May 15 - May 22 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Albert Ramos-Vinolas | Win | 6-1, 6-1 |
| Quarterfinals | Pablo Carreno Busta | Win | 6-3, 6-1 |
| Semifinals | Lukas Rosol | Win | 6-2, 4-6, 6-3 |
| Final | Marin Cilic | Win | 6-4, 7-6 (13-11) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benoit Paire | Win | 5-7, 6-2, 6-1 |
| Third Round | Juan Monaco | Loss | 7-6 (7-5), 3-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: Apr. 30 - May 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nick Kyrgios | Loss | 6-7 (7-9), 6-7 (2-7) |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Philipp Kohlschreiber | Win | 7-6 (7-2), 7-5 |
| Third Round | Gilles Simon | Win | 6-1, 6-2 |
| Quarterfinals | Rafael Nadal | Loss | 1-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrey Kuznetsov | Loss | 4-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Illya Marchenko | Win | 6-3, 6-2 |
| Third Round | Andrey Kuznetsov | Win | 6-4, 7-6 (7-5) |
| Fourth Round | David Goffin | Loss | 3-6, 7-5, 6-7 (5-7) |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 22 - Feb. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Sergiy Stakhovsky | Win | 5-7, 6-3, 7-5 |
| Second Round | Franko Skugor | Win | 7-5, 6-1 |
| Quarterfinals | Philipp Kohlschreiber | Win | 7-5, 6-1 |
| Semifinals | Nick Kyrgios | Win | 6-4, 3-0 Retired |
| Final | Marcos Baghdatis | Win | 6-4, 7-6 (15-13) |
| Open 13 | ||
| Surface: Hard | Date: Feb. 15 - Feb. 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sergiy Stakhovsky | Win | 6-4, 4-6, 7-6 (10-8) |
| Quarterfinals | Benoit Paire | Loss | 4-6, 6-1, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 31 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Dmitry Tursunov | Win | 7-6 (7-2), 6-3, 0-0 Retired |
| Second Round | Radek Stepanek | Win | 6-2, 6-3, 6-4 |
| Third Round | Lukas Rosol | Win | 6-2, 6-3, 7-6 (7-3) |
| Fourth Round | Milos Raonic | Loss | 4-6, 3-6, 7-5, 6-4, 3-6 |
| Aircel Chennai Open | ||
| Surface: Hard | Date: Jan. 4 - Jan. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrey Rublev | Win | 6-3, 6-2 |
| Quarterfinals | Guillermo Garcia-Lopez | Win | 6-4, 6-4 |
| Semifinals | Benoit Paire | Win | 6-3, 6-4 |
| Final | Borna Coric | Win | 6-3, 7-5 |
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