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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Vasek Pospisil | Win | 6-2 Retired |
| Second Round | Feliciano Lopez | Loss | 3-6, 2-6, 6-3, 1-6 |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Horacio Zeballos | Loss | 6-3, 5-7, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mischa Zverev | Loss | 4-6, 4-6 |
| Abierto Mexicano de Tenis Mifel presentado por Cinemex | ||
| Surface: Hard | Date: Jul. 31 - Aug. 5 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Ernesto Escobedo | Win | 6-7 (6-8), 7-5, 6-2 |
| Second Round | Vincent Millot | Loss | 6-1, 2-6, 4-6 |
| German Tennis Championships 2017 | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jiri Vesely | Loss | 6-7 (7-9), 7-6 (7-0), 3-6 |
| SkiStar Swedish Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Elias Ymer | Win | 4-6, 6-3, 6-4 |
| Second Round | Facundo Bagnis | Win | 6-3, 6-2 |
| Quarterfinals | Albert Ramos-Vinolas | Win | 6-3, 6-2 |
| Semifinals | David Ferrer | Loss | 1-6, 7-6 (7-3), 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Kevin Anderson | Loss | 6-2, 6-7 (5-7), 6-7 (8-10), 3-6 |
| Antalya Open | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Steve Darcis | Win | 6-3, 6-4 |
| Quarterfinals | Adrian Mannarino | Loss | 6-2, 5-7, 2-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kei Nishikori | Loss | 7-6 (9-7), 3-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexander Zverev | Win | 6-4, 3-6, 6-4, 6-2 |
| Second Round | Pierre-Hugues Herbert | Win | 6-3, 3-6, 4-6, 6-3, 6-3 |
| Third Round | Pablo Cuevas | Win | 6-2, 6-1, 6-3 |
| Fourth Round | Kei Nishikori | Loss | 6-0, 4-6, 4-6, 0-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Donald Young | Win | 6-3, 6-3 |
| Second Round | David Goffin | Loss | 6-3, 3-6, 2-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexander Zverev | Loss | 5-7, 3-6 |
| Gazprom Hungarian Open | ||
| Surface: Red Clay | Date: Apr. 24 - Apr. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | 7-6 (8-6), 6-3 |
| Quarterfinals | Laslo Djere | Loss | 6-2, 6-7 (4-7), 2-6 |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 10 - Apr. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Kevin Anderson | Win | 7-6 (7-4), 7-6 (7-4) |
| Second Round | Nicolas Kicker | Win | 7-6 (7-4), 6-1 |
| Quarterfinals | Steve Johnson | Loss | 2-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 25 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ernesto Escobedo | Win | 7-6 (11-9), 7-5 |
| Third Round | Kei Nishikori | Loss | 6-7 (2-7), 7-6 (7-5), 1-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pierre-Hugues Herbert | Win | 7-6 (7-5), 6-1 |
| Third Round | Rafael Nadal | Loss | 3-6, 5-7 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Andreas Seppi | Win | 6-2, 7-5 |
| Second Round | Roberto Bautista Agut | Win | 6-4, 3-6, 7-5 |
| Quarterfinals | Gael Monfils | Win | 6-3, 7-5 |
| Semifinals | Robin Haase | Win | 7-6 (7-5), 5-7, 6-1 |
| Final | Andy Murray | Loss | 3-6, 2-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Martin Klizan | Loss | 4-6, 6-0, 1-6 |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Gregoire Barrere | Win | 6-2, 6-1 |
| Second Round | Daniil Medvedev | Loss | 3-6, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Novak Djokovic | Loss | 1-6, 6-7 (4-7), 2-6 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Jan. 2 - Jan. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Vasek Pospisil | Win | 7-5, 6-0 |
| Second Round | David Goffin | Win | 6-1, 7-6 (8-6) |
| Quarterfinals | Ivo Karlovic | Win | 6-2, 7-5 |
| Semifinals | Novak Djokovic | Loss | 6-4, 6-7 (7-9), 3-6 |
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