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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Yannick Hanfmann |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Dominik Koepfer | Win | 6-2, 3-2 Retired |
| Second Round | Lloyd Harris | Win | 6-3, 6-1, 7-6 (7-4) |
| Third Round | Daniel Evans | Win | 6-2, 6-3, 4-6, 6-3 |
| Fourth Round | Matteo Arnaldi | Win | 6-3, 6-3, 6-4 |
| Quarterfinals | Alexander Zverev | Win | 6-3, 6-2, 6-4 |
| Semifinals | Daniil Medvedev | Loss | 6-7 (3-7), 1-6, 6-3, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jordan Thompson | Win | 7-5, 4-6, 6-3 |
| Third Round | Tommy Paul | Win | 7-6 (8-6), 6-7 (0-7), 6-3 |
| Quarterfinals | Max Purcell | Win | 4-6, 6-3, 6-4 |
| Semifinals | Hubert Hurkacz | Win | 2-6, 7-6 (7-4), 6-3 |
| Final | Novak Djokovic | Loss | 7-5, 6-7 (7-9), 6-7 (4-7) |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ben Shelton | Win | 6-3, 7-6 (7-3) |
| Third Round | Hubert Hurkacz | Win | 3-6, 7-6 (7-2), 7-6 (7-3) |
| Quarterfinals | Tommy Paul | Loss | 3-6, 6-4, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jeremy Chardy | Win | |
| Second Round | Alexandre Muller | Win | |
| Third Round | Nicolas Jarry | Win | |
| Fourth Round | Matteo Berrettini | Win | |
| Quarterfinals | Holger Rune | Win | |
| Semifinals | Daniil Medvedev | Win | |
| Final | Novak Djokovic | Win |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Arthur Rinderknech | Win | |
| Second Round | Jiri Lehecka | Win | |
| Quarterfinals | Grigor Dimitrov | Win | |
| Semifinals | Sebastian Korda | Win | |
| Final | Alex De Minaur | Win |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Flavio Cobolli | Win | |
| Second Round | Taro Daniel | Win | |
| Third Round | Denis Shapovalov | Win | |
| Fourth Round | Lorenzo Musetti | Win | |
| Quarterfinals | Stefanos Tsitsipas | Win | |
| Semifinals | Novak Djokovic | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Albert Ramos-Vinolas | Win | |
| Third Round | Fabian Marozsan | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emil Ruusuvuori | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Fourth Round | Alexander Zverev | Win | |
| Quarterfinals | Karen Khachanov | Win | |
| Semifinals | Borna Coric | Win | |
| Final | Jan-Lennard Struff | Win |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nuno Borges | Win | |
| Third Round | Roberto Bautista Agut | Win | |
| Quarterfinals | Alejandro Davidovich Fokina | Win | |
| Semifinals | Daniel Evans | Win | |
| Final | Stefanos Tsitsipas | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Facundo Bagnis | Win | |
| Third Round | Dusan Lajovic | Win | |
| Fourth Round | Tommy Paul | Win | |
| Quarterfinals | Taylor Fritz | Win | |
| Semifinals | Jannik Sinner | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thanasi Kokkinakis | Win | |
| Third Round | Tallon Griekspoor | Win | |
| Fourth Round | Jack Draper | Win | |
| Quarterfinals | Felix Auger-Aliassime | Win | |
| Semifinals | Jannik Sinner | Win | |
| Final | Daniil Medvedev | Win |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Mateus De Carvalho Cardoso Alves | Win | |
| Second Round | Fabio Fognini | Win | |
| Quarterfinals | Dusan Lajovic | Win | |
| Semifinals | Nicolas Jarry | Win | |
| Final | Cameron Norrie | Loss |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laslo Djere | Win | |
| Quarterfinals | Dusan Lajovic | Win | |
| Semifinals | Bernabe Zapata Miralles | Win | |
| Final | Cameron Norrie | Win |
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