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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Karen Khachanov | Win | 6-3, 1-6, 6-2 |
| Second Round | Carlos Alcaraz | Loss | 2-6, 2-6 |
| Chengdu Open | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Philip Sekulic | Win | 7-6 (7-3), 6-7 (4-7), 6-0 |
| Quarterfinals | Arthur Rinderknech | Win | 6-3, 6-3 |
| Semifinals | Roman Safiullin | Loss | 3-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Titouan Droguet | Loss | 3-6, 6-0, 7-6 (7-5), 3-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniel Evans | Win | 6-4, 6-3 |
| Second Round | Daniil Medvedev | Loss | 3-6, 2-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Yoshihito Nishioka | Win | 6-4, 6-1 |
| Second Round | Thanasi Kokkinakis | Win | 4-6, 7-5, 6-4 |
| Third Round | Daniil Medvedev | Loss | 4-6, 4-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Elias Ymer | Win | 6-4, 6-1 |
| Second Round | Jozef Kovalik | Win | 3-6, 6-2, 6-4 |
| Quarterfinals | Laslo Djere | Loss | 5-7, 3-6 |
| Nordea Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Arnaldi | Win | |
| Quarterfinals | Filip Misolic | Win | |
| Semifinals | Casper Ruud | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Juan Pablo Varillas | Win | |
| Second Round | Jaume Munar | Win | |
| Third Round | Hubert Hurkacz | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Jan Choinski | Win | |
| Second Round | Ben Shelton | Win | |
| Quarterfinals | Holger Rune | Loss |
| Boss Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Borna Gojo | Win | |
| Second Round | Gregoire Barrere | Win | |
| Quarterfinals | Frances Tiafoe | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | |
| Second Round | Alexander Shevchenko | Win | |
| Third Round | Cameron Norrie | Win | |
| Fourth Round | Carlos Alcaraz | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Arnaldi | Win | |
| Third Round | Frances Tiafoe | Win | |
| Fourth Round | Stefanos Tsitsipas | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jason Kubler | Win | |
| Third Round | Cameron Norrie | Win | |
| Quarterfinals | Jannik Sinner | Win | |
| Semifinals | Stefanos Tsitsipas | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Miomir Kecmanovic | Win | |
| Second Round | Luca Nardi | Win | |
| Third Round | Novak Djokovic | Win | |
| Quarterfinals | Jannik Sinner | Loss |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hugo Gaston | Win | |
| Quarterfinals | Alexandre Muller | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Adrian Mannarino | Loss |
| Chile Dove Men+Care Open | ||
| Surface: Clay | Date: Feb. 27 - Mar. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Loss |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Nicolas Jarry | Loss |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Cachin | Win | |
| Quarterfinals | Juan Pablo Varillas | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Lloyd Harris | Loss |
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