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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Zachary Svajda | Win | 5-7, 6-4, 6-4, 6-3 |
| Second Round | Jiri Vesely | Loss | 6-7 (5-7), 2-6, 6-3, 6-2, 6-7 (6-10) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Dusan Lajovic | Loss | 3-6, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexis Galarneau | Win | 6-2, 4-6, 6-4 |
| Second Round | Tommy Paul | Loss | 6-7 (2-7), 7-6 (7-2), 3-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Yannick Hanfmann | Loss | 6-4, 2-6, 2-4 Retired |
| Nordea Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Luca Van Assche | Win | |
| Quarterfinals | Federico Coria | Win | |
| Semifinals | Andrey Rublev | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Nuno Borges | Win | |
| Second Round | Jiri Lehecka | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 26 - Jul. 1 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marc-Andrea Huesler | Win | |
| Quarterfinals | Zhizhen Zhang | Win | |
| Semifinals | Mackenzie McDonald | Win | |
| Final | Tommy Paul | Win |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Tommy Paul | Win | |
| Second Round | Grigor Dimitrov | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Jaume Munar | Win | |
| Second Round | Yannick Hanfmann | Win | |
| Third Round | Taylor Fritz | Win | |
| Fourth Round | Holger Rune | Loss |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Juan Pablo Varillas | Win | |
| Quarterfinals | Jack Draper | Win | |
| Semifinals | Cameron Norrie | Win | |
| Final | Arthur Fils | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yibing Wu | Win | |
| Third Round | Gregoire Barrere | Win | |
| Fourth Round | Jannik Sinner | Win | |
| Quarterfinals | Casper Ruud | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Cachin | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Francesco Passaro | Win | |
| Third Round | Casper Ruud | Win | |
| Quarterfinals | Daniel Evans | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Cameron Norrie | Win | |
| Second Round | Matteo Berrettini | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 25 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aleksandar Kovacevic | Win | |
| Third Round | Felix Auger-Aliassime | Win | |
| Fourth Round | Lorenzo Sonego | Win | |
| Quarterfinals | Karen Khachanov | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | |
| Third Round | Felix Auger-Aliassime | Loss |
| Chile Dove Men+Care Open | ||
| Surface: Clay | Date: Feb. 27 - Mar. 5 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Martin Etcheverry | Loss |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Roberto Carballes Baena | Win | |
| Second Round | Bernabe Zapata Miralles | Loss |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Yannick Hanfmann | Win | |
| Second Round | Jaume Munar | Win | |
| Quarterfinals | Bernabe Zapata Miralles | Loss |
| Cordoba Open | ||
| Surface: Clay | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Federico Delbonis | Win | |
| Quarterfinals | Federico Coria | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Guido Pella | Win | |
| Second Round | Corentin Moutet | Win | |
| Third Round | Felix Auger-Aliassime | Loss |
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