(AP Photo/Alastair Grant)

WIMBLEDON, England (AP) The recurring cries of "Come on, Andy!" at Centre Court meandered somewhere along the continuum from pushing to pleading as two-time champion Andy Murray's shortest stay at Wimbledon came to a close.

Unable to overcome big John Isner's big serves, the way he always has in the past, the revered Murray lost in the second round to the 20th-seeded American 6-4, 7-6 (4), 6-7 (3), 6-4 on Wednesday night at the All England Club, capping a disappointing afternoon and evening in the grass-court Grand Slam tournament's main stadium for the locals.

Prior to Murray vs. Isner, the host country's other leading player, reigning U.S. Open champion Emma Raducanu, was eliminated by Caroline Garcia of France 6-3, 6-3.

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