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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | J. Grilli | Pit | 24 | 0 | 0 | 1 | 19 | 21.2 | 11 | 3 | 3 | 5 | 34 | 0 | 0 | 0.74 | 1.25 |
| 2 | C. Kimbrel | Atl | 19 | 0 | 1 | 1 | 14 | 18.1 | 13 | 5 | 5 | 4 | 29 | 0 | 3 | 0.93 | 2.45 |
| 3t | E. Mujica | StL | 20 | 0 | 0 | 0 | 13 | 20.0 | 12 | 5 | 5 | 1 | 19 | 4 | 0 | 0.65 | 2.25 |
| 3t | S. Romo | SF | 23 | 0 | 2 | 2 | 13 | 20.0 | 16 | 6 | 6 | 3 | 23 | 0 | 2 | 0.95 | 2.70 |
| 3t | R. Soriano | Was | 21 | 0 | 1 | 1 | 13 | 21.0 | 20 | 8 | 7 | 4 | 15 | 0 | 3 | 1.14 | 3.00 |
| 6 | H. Street | SD | 20 | 0 | 0 | 3 | 11 | 19.1 | 16 | 9 | 9 | 8 | 13 | 0 | 1 | 1.24 | 4.19 |
| 7t | R. Betancourt | Col | 19 | 0 | 1 | 1 | 10 | 17.1 | 11 | 5 | 3 | 8 | 18 | 0 | 0 | 1.10 | 1.56 |
| 7t | A. Chapman | Cin | 23 | 0 | 3 | 2 | 10 | 21.0 | 15 | 7 | 7 | 9 | 34 | 0 | 2 | 1.14 | 3.00 |
| 9t | J. Henderson | Mil | 19 | 0 | 2 | 1 | 9 | 19.0 | 10 | 2 | 2 | 5 | 23 | 0 | 0 | 0.79 | 0.95 |
| 9t | B. League | LAD | 17 | 0 | 0 | 2 | 9 | 17.1 | 20 | 13 | 10 | 5 | 8 | 0 | 2 | 1.44 | 5.19 |
| 11 | J. Papelbon | Phi | 17 | 0 | 0 | 0 | 8 | 17.2 | 9 | 2 | 2 | 2 | 12 | 0 | 0 | 0.62 | 1.02 |
| 12t | H. Bell | Ari | 19 | 0 | 2 | 0 | 6 | 18.0 | 23 | 9 | 9 | 3 | 23 | 1 | 2 | 1.44 | 4.50 |
| 12t | K. Gregg | ChC | 12 | 0 | 0 | 0 | 6 | 11.0 | 6 | 1 | 0 | 4 | 12 | 0 | 0 | 0.91 | 0.00 |
| 12t | B. Parnell | NYM | 20 | 0 | 4 | 1 | 6 | 20.1 | 13 | 5 | 5 | 5 | 18 | 0 | 2 | 0.89 | 2.21 |
| 15t | S. Cishek | Mia | 19 | 0 | 1 | 4 | 5 | 19.1 | 17 | 11 | 10 | 10 | 18 | 1 | 1 | 1.40 | 4.66 |
| 15t | J. Putz | Ari | 14 | 0 | 2 | 1 | 5 | 12.2 | 12 | 6 | 6 | 8 | 17 | 0 | 4 | 1.58 | 4.26 |
| 17 | J. Hoover | Cin | 21 | 0 | 0 | 3 | 3 | 19.1 | 15 | 8 | 8 | 9 | 19 | 2 | 0 | 1.24 | 3.72 |
| 18t | M. Boggs | StL | 15 | 0 | 0 | 2 | 2 | 12.2 | 18 | 17 | 16 | 12 | 10 | 0 | 2 | 2.37 | 11.37 |
| 18t | K. Fujikawa | ChC | 11 | 0 | 1 | 1 | 2 | 10.1 | 11 | 7 | 7 | 1 | 13 | 1 | 1 | 1.16 | 6.10 |
| 18t | K. Jansen | LAD | 23 | 0 | 1 | 3 | 2 | 22.1 | 18 | 9 | 9 | 6 | 31 | 9 | 1 | 1.07 | 3.63 |
| 18t | C. Marmol | ChC | 20 | 0 | 2 | 2 | 2 | 18.0 | 17 | 9 | 9 | 13 | 18 | 3 | 2 | 1.67 | 4.50 |
| 18t | M. Reynolds | Ari | 22 | 0 | 0 | 2 | 2 | 20.0 | 18 | 3 | 3 | 2 | 20 | 4 | 0 | 1.00 | 1.35 |