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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | Y. Darvish | Tex | 15 | 15 | 7 | 3 | 0 | 101.1 | 67 | 34 | 32 | 31 | 137 | 0 | 0 | 0.97 | 2.84 |
| 2 | M. Scherzer | Det | 14 | 14 | 10 | 0 | 0 | 96.1 | 64 | 34 | 33 | 24 | 116 | 0 | 0 | 0.91 | 3.08 |
| 3 | F. Hernandez | Sea | 15 | 15 | 8 | 4 | 0 | 104.2 | 88 | 30 | 27 | 20 | 110 | 0 | 0 | 1.03 | 2.32 |
| 4 | J. Verlander | Det | 15 | 15 | 8 | 5 | 0 | 92.0 | 92 | 40 | 38 | 32 | 106 | 0 | 0 | 1.35 | 3.72 |
| 5 | J. Masterson | Cle | 15 | 15 | 8 | 5 | 0 | 102.1 | 80 | 40 | 40 | 41 | 102 | 0 | 0 | 1.18 | 3.52 |
| 6 | A. Sanchez | Det | 13 | 13 | 6 | 5 | 0 | 81.2 | 71 | 28 | 25 | 23 | 101 | 0 | 0 | 1.15 | 2.76 |
| 7 | J. Shields | KC | 15 | 15 | 2 | 6 | 0 | 106.0 | 89 | 33 | 32 | 30 | 95 | 0 | 0 | 1.12 | 2.72 |
| 8 | H. Iwakuma | Sea | 15 | 15 | 7 | 2 | 0 | 100.1 | 72 | 26 | 23 | 17 | 90 | 0 | 0 | 0.89 | 2.06 |
| 9 | C. Sabathia | NYY | 15 | 15 | 7 | 5 | 0 | 103.0 | 106 | 48 | 45 | 21 | 89 | 0 | 0 | 1.23 | 3.93 |
| 10 | R. Dempster | Bos | 14 | 14 | 4 | 7 | 0 | 83.1 | 71 | 43 | 39 | 40 | 87 | 0 | 0 | 1.33 | 4.21 |
| 11t | D. Holland | Tex | 14 | 14 | 5 | 4 | 0 | 90.0 | 96 | 37 | 33 | 22 | 86 | 0 | 0 | 1.31 | 3.30 |
| 11t | C. Sale | CWS | 12 | 12 | 5 | 5 | 0 | 85.1 | 58 | 26 | 23 | 19 | 86 | 0 | 0 | 0.90 | 2.43 |
| 13 | C. Wilson | LAA | 14 | 14 | 5 | 5 | 0 | 87.2 | 87 | 45 | 38 | 38 | 82 | 0 | 0 | 1.43 | 3.90 |
| 14 | C. Buchholz | Bos | 12 | 12 | 9 | 0 | 0 | 84.1 | 57 | 16 | 16 | 29 | 81 | 0 | 0 | 1.02 | 1.71 |
| 15 | J. Lester | Bos | 15 | 15 | 6 | 4 | 0 | 94.2 | 92 | 48 | 46 | 33 | 80 | 0 | 0 | 1.32 | 4.37 |
| 16 | E. Santana | KC | 14 | 14 | 5 | 5 | 0 | 99.0 | 82 | 32 | 29 | 15 | 77 | 0 | 0 | 0.98 | 2.64 |
| 17t | A. Cobb | TB | 13 | 13 | 6 | 2 | 0 | 83.2 | 74 | 29 | 28 | 23 | 76 | 0 | 0 | 1.16 | 3.01 |
| 17t | D. Fister | Det | 14 | 14 | 6 | 4 | 0 | 92.2 | 90 | 38 | 33 | 14 | 76 | 0 | 0 | 1.12 | 3.21 |
| 19 | F. Doubront | Bos | 13 | 12 | 4 | 3 | 0 | 74.0 | 78 | 39 | 36 | 32 | 74 | 0 | 0 | 1.49 | 4.38 |
| 20 | T. Milone | Oak | 14 | 14 | 6 | 6 | 0 | 89.2 | 86 | 40 | 36 | 19 | 73 | 0 | 0 | 1.17 | 3.61 |