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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | C. Buchholz | Bos | 10 | 10 | 7 | 0 | 0 | 72.2 | 49 | 14 | 14 | 27 | 73 | 0 | 0 | 1.05 | 1.73 |
| 2 | F. Hernandez | Sea | 10 | 10 | 5 | 3 | 0 | 69.2 | 58 | 19 | 16 | 12 | 72 | 0 | 0 | 1.00 | 2.07 |
| 3 | M. Moore | TB | 9 | 9 | 8 | 0 | 0 | 55.0 | 34 | 14 | 14 | 26 | 54 | 0 | 0 | 1.09 | 2.29 |
| 4 | H. Iwakuma | Sea | 10 | 10 | 5 | 1 | 0 | 64.2 | 45 | 19 | 17 | 11 | 61 | 0 | 0 | 0.87 | 2.37 |
| 5 | J. Shields | KC | 10 | 10 | 2 | 5 | 0 | 73.0 | 55 | 21 | 20 | 15 | 69 | 0 | 0 | 0.96 | 2.47 |
| 6 | J. Williams | LAA | 12 | 4 | 3 | 1 | 0 | 46.1 | 38 | 16 | 13 | 12 | 29 | 0 | 0 | 1.08 | 2.53 |
| 7 | C. Sale | CWS | 9 | 9 | 5 | 2 | 0 | 64.0 | 44 | 19 | 18 | 15 | 61 | 0 | 0 | 0.92 | 2.53 |
| 8 | Z. McAllister | Cle | 8 | 8 | 3 | 3 | 0 | 51.0 | 46 | 20 | 15 | 14 | 34 | 0 | 0 | 1.18 | 2.65 |
| 9 | H. Kuroda | NYY | 10 | 10 | 6 | 3 | 0 | 60.2 | 50 | 18 | 18 | 14 | 39 | 0 | 0 | 1.05 | 2.67 |
| 10 | A. Cobb | TB | 9 | 9 | 5 | 2 | 0 | 59.1 | 53 | 19 | 18 | 14 | 54 | 0 | 0 | 1.13 | 2.73 |
| 11t | A. Sanchez | Det | 9 | 9 | 4 | 4 | 0 | 55.1 | 54 | 20 | 17 | 14 | 68 | 0 | 0 | 1.23 | 2.77 |
| 11t | E. Santana | KC | 8 | 8 | 3 | 3 | 0 | 55.1 | 51 | 18 | 17 | 9 | 44 | 0 | 0 | 1.08 | 2.77 |
| 13 | J. Masterson | Cle | 10 | 10 | 7 | 2 | 0 | 70.0 | 53 | 22 | 22 | 26 | 71 | 0 | 0 | 1.13 | 2.83 |
| 14 | Y. Darvish | Tex | 10 | 10 | 7 | 2 | 0 | 66.2 | 42 | 21 | 21 | 22 | 91 | 0 | 0 | 0.96 | 2.84 |
| 15 | W. Chen | Bal | 8 | 8 | 3 | 3 | 0 | 47.1 | 45 | 16 | 16 | 12 | 27 | 0 | 0 | 1.20 | 3.04 |
| 16 | A. Ogando | Tex | 9 | 9 | 4 | 2 | 0 | 49.2 | 43 | 19 | 17 | 19 | 37 | 0 | 0 | 1.25 | 3.08 |
| 17 | J. Lester | Bos | 10 | 10 | 6 | 1 | 0 | 65.2 | 52 | 25 | 23 | 18 | 52 | 0 | 0 | 1.07 | 3.15 |
| 18 | D. Holland | Tex | 9 | 9 | 3 | 2 | 0 | 60.0 | 56 | 23 | 22 | 14 | 54 | 0 | 0 | 1.17 | 3.30 |
| 19 | J. Peavy | CWS | 8 | 8 | 5 | 2 | 0 | 51.2 | 42 | 20 | 19 | 13 | 58 | 0 | 0 | 1.06 | 3.31 |
| 20 | C. Wilson | LAA | 10 | 10 | 4 | 3 | 0 | 63.2 | 59 | 30 | 24 | 32 | 60 | 0 | 0 | 1.43 | 3.39 |