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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | J. Marquis | SD | 14 | 14 | 9 | 2 | 0 | 84.1 | 70 | 38 | 34 | 47 | 53 | 0 | 0 | 1.39 | 3.63 |
| 2t | G. Gonzalez | Was | 14 | 14 | 3 | 3 | 0 | 84.2 | 62 | 34 | 32 | 39 | 82 | 0 | 0 | 1.19 | 3.40 |
| 2t | T. Lincecum | SF | 14 | 14 | 4 | 7 | 0 | 82.2 | 81 | 48 | 42 | 39 | 81 | 0 | 0 | 1.45 | 4.57 |
| 4t | J. Locke | Pit | 14 | 14 | 6 | 1 | 0 | 82.1 | 58 | 21 | 20 | 36 | 60 | 0 | 0 | 1.14 | 2.19 |
| 4t | E. Volquez | SD | 14 | 14 | 5 | 5 | 0 | 76.2 | 88 | 51 | 50 | 36 | 58 | 0 | 0 | 1.62 | 5.87 |
| 6 | A. Burnett | Pit | 14 | 14 | 4 | 6 | 0 | 89.1 | 66 | 32 | 31 | 35 | 99 | 0 | 0 | 1.13 | 3.12 |
| 7t | T. Cahill | Ari | 14 | 14 | 3 | 8 | 0 | 86.1 | 81 | 40 | 38 | 33 | 61 | 0 | 0 | 1.32 | 3.96 |
| 7t | J. Niese | NYM | 13 | 13 | 3 | 6 | 0 | 73.2 | 83 | 42 | 34 | 33 | 44 | 0 | 0 | 1.57 | 4.15 |
| 7t | J. Samardzija | ChC | 14 | 14 | 3 | 7 | 0 | 91.0 | 77 | 39 | 35 | 33 | 104 | 0 | 0 | 1.21 | 3.46 |
| 10t | L. Lynn | StL | 14 | 14 | 9 | 1 | 0 | 86.0 | 70 | 34 | 34 | 32 | 88 | 0 | 0 | 1.19 | 3.56 |
| 10t | W. Peralta | Mil | 15 | 15 | 4 | 8 | 0 | 80.0 | 101 | 63 | 54 | 32 | 45 | 0 | 0 | 1.66 | 6.08 |
| 12 | C. Kershaw | LAD | 15 | 15 | 5 | 4 | 0 | 107.1 | 73 | 26 | 22 | 31 | 104 | 0 | 0 | 0.97 | 1.84 |
| 13 | Y. Gallardo | Mil | 15 | 15 | 6 | 6 | 0 | 87.2 | 88 | 45 | 43 | 30 | 69 | 0 | 0 | 1.35 | 4.41 |
| 14t | M. Cain | SF | 14 | 14 | 5 | 3 | 0 | 88.0 | 72 | 47 | 46 | 29 | 78 | 0 | 0 | 1.15 | 4.70 |
| 14t | E. Jackson | ChC | 13 | 13 | 3 | 8 | 0 | 71.2 | 82 | 50 | 43 | 29 | 71 | 0 | 0 | 1.55 | 5.40 |
| 14t | I. Kennedy | Ari | 14 | 14 | 3 | 4 | 0 | 84.2 | 82 | 51 | 49 | 29 | 73 | 0 | 0 | 1.31 | 5.21 |
| 17t | C. Hamels | Phi | 15 | 15 | 2 | 10 | 0 | 94.0 | 91 | 49 | 46 | 28 | 89 | 0 | 0 | 1.27 | 4.40 |
| 17t | M. Magill | LAD | 6 | 6 | 0 | 2 | 0 | 27.2 | 27 | 25 | 20 | 28 | 26 | 0 | 0 | 1.99 | 6.51 |
| 17t | T. Wood | ChC | 13 | 13 | 5 | 5 | 0 | 85.0 | 57 | 26 | 25 | 28 | 60 | 0 | 0 | 1.00 | 2.65 |
| 20t | J. De La Rosa | Col | 14 | 14 | 7 | 4 | 0 | 80.0 | 79 | 32 | 31 | 27 | 53 | 0 | 0 | 1.33 | 3.49 |
| 20t | J. Fernandez | Mia | 13 | 13 | 4 | 3 | 0 | 72.1 | 56 | 29 | 25 | 27 | 77 | 0 | 0 | 1.15 | 3.11 |
| 20t | W. Miley | Ari | 14 | 14 | 4 | 6 | 0 | 83.1 | 92 | 49 | 43 | 27 | 60 | 0 | 0 | 1.43 | 4.64 |
| 20t | J. Nicasio | Col | 14 | 14 | 4 | 2 | 0 | 74.0 | 73 | 42 | 40 | 27 | 51 | 0 | 0 | 1.35 | 4.86 |
| 20t | B. Zito | SF | 13 | 13 | 4 | 5 | 0 | 73.1 | 90 | 47 | 39 | 27 | 43 | 0 | 0 | 1.60 | 4.79 |