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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | C. Wilson | LAA | 10 | 10 | 4 | 3 | 0 | 63.2 | 59 | 30 | 24 | 32 | 60 | 0 | 0 | 1.43 | 3.39 |
| 2 | L. Harrell | Hou | 10 | 10 | 3 | 5 | 0 | 56.1 | 63 | 30 | 29 | 30 | 32 | 0 | 0 | 1.65 | 4.63 |
| 3 | R. Dickey | Tor | 10 | 10 | 4 | 5 | 0 | 62.0 | 53 | 35 | 31 | 28 | 53 | 0 | 0 | 1.31 | 4.50 |
| 4 | C. Buchholz | Bos | 10 | 10 | 7 | 0 | 0 | 72.2 | 49 | 14 | 14 | 27 | 73 | 0 | 0 | 1.05 | 1.73 |
| 5t | J. Masterson | Cle | 10 | 10 | 7 | 2 | 0 | 70.0 | 53 | 22 | 22 | 26 | 71 | 0 | 0 | 1.13 | 2.83 |
| 5t | M. Moore | TB | 9 | 9 | 8 | 0 | 0 | 55.0 | 34 | 14 | 14 | 26 | 54 | 0 | 0 | 1.09 | 2.29 |
| 7t | R. Dempster | Bos | 9 | 9 | 2 | 4 | 0 | 52.2 | 44 | 29 | 25 | 25 | 63 | 0 | 0 | 1.31 | 4.27 |
| 7t | J. Parker | Oak | 10 | 10 | 2 | 6 | 0 | 54.2 | 63 | 36 | 35 | 25 | 40 | 0 | 0 | 1.61 | 5.76 |
| 9 | F. Doubront | Bos | 8 | 7 | 3 | 2 | 0 | 43.1 | 51 | 27 | 27 | 24 | 45 | 0 | 0 | 1.73 | 5.61 |
| 10t | Y. Darvish | Tex | 10 | 10 | 7 | 2 | 0 | 66.2 | 42 | 21 | 21 | 22 | 91 | 0 | 0 | 0.96 | 2.84 |
| 10t | W. Davis | KC | 9 | 9 | 3 | 3 | 0 | 45.2 | 67 | 34 | 30 | 22 | 36 | 0 | 0 | 1.95 | 5.91 |
| 10t | J. Hammel | Bal | 10 | 10 | 6 | 2 | 0 | 57.0 | 65 | 37 | 34 | 22 | 42 | 0 | 0 | 1.53 | 5.37 |
| 10t | U. Jimenez | Cle | 9 | 9 | 3 | 3 | 0 | 44.2 | 40 | 30 | 30 | 22 | 47 | 0 | 0 | 1.39 | 6.04 |
| 14t | C. Tillman | Bal | 9 | 9 | 3 | 2 | 0 | 53.2 | 47 | 21 | 21 | 21 | 41 | 0 | 0 | 1.27 | 3.52 |
| 14t | J. Verlander | Det | 10 | 10 | 5 | 4 | 0 | 59.0 | 60 | 26 | 24 | 21 | 69 | 0 | 0 | 1.37 | 3.66 |
| 16t | J. Guthrie | KC | 9 | 9 | 5 | 2 | 0 | 59.1 | 61 | 24 | 23 | 20 | 32 | 0 | 0 | 1.37 | 3.49 |
| 16t | B. Norris | Hou | 10 | 10 | 4 | 4 | 0 | 56.0 | 64 | 29 | 24 | 20 | 35 | 0 | 0 | 1.50 | 3.86 |
| 16t | J. Saunders | Sea | 9 | 9 | 3 | 4 | 0 | 52.2 | 65 | 34 | 33 | 20 | 22 | 0 | 0 | 1.61 | 5.64 |
| 16t | J. Vargas | LAA | 9 | 9 | 3 | 3 | 0 | 58.1 | 62 | 23 | 23 | 20 | 40 | 0 | 0 | 1.41 | 3.55 |
| 20t | J. Happ | Tor | 7 | 7 | 2 | 2 | 0 | 33.0 | 32 | 19 | 18 | 19 | 26 | 0 | 0 | 1.55 | 4.91 |
| 20t | A. Ogando | Tex | 9 | 9 | 4 | 2 | 0 | 49.2 | 43 | 19 | 17 | 19 | 37 | 0 | 0 | 1.25 | 3.08 |