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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | J. Johnson | Bal | 37 | 0 | 2 | 5 | 26 | 35.1 | 32 | 16 | 15 | 8 | 26 | 0 | 4 | 1.13 | 3.82 |
| 2 | J. Grilli | Pit | 34 | 0 | 0 | 1 | 25 | 31.2 | 17 | 3 | 3 | 7 | 54 | 0 | 0 | 0.76 | 0.85 |
| 3 | M. Rivera | NYY | 28 | 0 | 0 | 1 | 24 | 25.0 | 28 | 6 | 5 | 6 | 24 | 0 | 1 | 1.36 | 1.80 |
| 4 | J. Nathan | Tex | 30 | 0 | 1 | 0 | 21 | 28.1 | 15 | 6 | 6 | 9 | 28 | 0 | 1 | 0.85 | 1.91 |
| 5t | A. Reed | CWS | 30 | 0 | 2 | 0 | 20 | 32.0 | 24 | 12 | 12 | 9 | 36 | 0 | 2 | 1.03 | 3.38 |
| 5t | E. Mujica | StL | 30 | 0 | 0 | 0 | 20 | 31.0 | 20 | 7 | 7 | 1 | 27 | 4 | 0 | 0.68 | 2.03 |
| 7 | C. Kimbrel | Atl | 27 | 0 | 2 | 1 | 19 | 26.1 | 20 | 5 | 5 | 7 | 37 | 0 | 3 | 1.03 | 1.71 |
| 8t | R. Soriano | Was | 28 | 0 | 1 | 1 | 18 | 28.0 | 28 | 9 | 8 | 5 | 25 | 0 | 3 | 1.18 | 2.57 |
| 8t | A. Chapman | Cin | 33 | 0 | 3 | 2 | 18 | 31.0 | 18 | 7 | 7 | 13 | 54 | 0 | 2 | 1.00 | 2.03 |
| 10t | G. Balfour | Oak | 30 | 0 | 0 | 0 | 17 | 29.2 | 20 | 4 | 4 | 12 | 29 | 0 | 0 | 1.08 | 1.21 |
| 10t | S. Romo | SF | 31 | 0 | 3 | 3 | 17 | 27.1 | 24 | 9 | 8 | 5 | 30 | 0 | 3 | 1.06 | 2.63 |
| 10t | G. Perkins | Min | 27 | 0 | 1 | 0 | 17 | 26.2 | 15 | 7 | 7 | 6 | 38 | 0 | 2 | 0.79 | 2.36 |
| 13 | T. Wilhelmsen | Sea | 30 | 0 | 0 | 2 | 16 | 31.0 | 20 | 14 | 13 | 17 | 22 | 0 | 5 | 1.19 | 3.77 |
| 14t | C. Janssen | Tor | 23 | 0 | 1 | 0 | 15 | 22.2 | 13 | 6 | 6 | 4 | 22 | 0 | 1 | 0.75 | 2.38 |
| 14t | G. Holland | KC | 27 | 0 | 2 | 1 | 15 | 26.0 | 18 | 8 | 6 | 11 | 41 | 1 | 2 | 1.12 | 2.08 |
| 14t | E. Frieri | LAA | 29 | 0 | 0 | 1 | 15 | 30.0 | 18 | 9 | 9 | 18 | 44 | 1 | 1 | 1.20 | 2.70 |
| 17t | J. Veras | Hou | 31 | 0 | 0 | 4 | 14 | 31.0 | 22 | 14 | 14 | 13 | 36 | 0 | 3 | 1.13 | 4.06 |
| 17t | H. Street | SD | 24 | 0 | 0 | 3 | 14 | 23.1 | 21 | 11 | 11 | 8 | 13 | 0 | 1 | 1.24 | 4.24 |
| 17t | F. Rodney | TB | 30 | 0 | 2 | 2 | 14 | 29.1 | 22 | 17 | 17 | 23 | 37 | 0 | 5 | 1.53 | 5.22 |
| 17t | J. Papelbon | Phi | 26 | 0 | 1 | 0 | 14 | 26.2 | 16 | 5 | 5 | 3 | 24 | 0 | 1 | 0.71 | 1.69 |
| 17t | B. League | LAD | 26 | 0 | 2 | 3 | 14 | 26.0 | 32 | 19 | 16 | 8 | 13 | 0 | 4 | 1.54 | 5.54 |
| 22 | H. Bell | Ari | 29 | 0 | 2 | 1 | 12 | 27.2 | 34 | 13 | 13 | 8 | 31 | 1 | 2 | 1.52 | 4.23 |
| 23 | R. Betancourt | Col | 22 | 0 | 1 | 3 | 11 | 19.2 | 15 | 9 | 7 | 9 | 22 | 0 | 1 | 1.22 | 3.20 |
| 24t | B. Parnell | NYM | 30 | 0 | 5 | 3 | 10 | 30.0 | 23 | 10 | 9 | 8 | 28 | 0 | 3 | 1.03 | 2.70 |
| 24t | S. Cishek | Mia | 30 | 0 | 1 | 4 | 10 | 29.1 | 21 | 13 | 12 | 12 | 26 | 1 | 2 | 1.13 | 3.68 |
| 24t | K. Gregg | ChC | 23 | 0 | 2 | 0 | 10 | 22.1 | 15 | 3 | 2 | 7 | 24 | 0 | 0 | 0.99 | 0.81 |