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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | J. Johnson | Bal | 36 | 0 | 2 | 5 | 25 | 34.1 | 31 | 16 | 15 | 7 | 26 | 0 | 4 | 1.11 | 3.93 |
| 2 | M. Rivera | NYY | 28 | 0 | 0 | 1 | 24 | 25.0 | 28 | 6 | 5 | 6 | 24 | 0 | 1 | 1.36 | 1.80 |
| 3 | J. Nathan | Tex | 30 | 0 | 1 | 0 | 21 | 28.1 | 15 | 6 | 6 | 9 | 28 | 0 | 1 | 0.85 | 1.91 |
| 4 | A. Reed | CWS | 30 | 0 | 2 | 0 | 20 | 32.0 | 24 | 12 | 12 | 9 | 36 | 0 | 2 | 1.03 | 3.38 |
| 5 | G. Balfour | Oak | 29 | 0 | 0 | 0 | 17 | 28.2 | 20 | 4 | 4 | 12 | 29 | 0 | 0 | 1.12 | 1.26 |
| 6t | G. Perkins | Min | 26 | 0 | 1 | 0 | 16 | 25.2 | 15 | 7 | 7 | 6 | 36 | 0 | 2 | 0.82 | 2.45 |
| 6t | T. Wilhelmsen | Sea | 29 | 0 | 0 | 2 | 16 | 29.1 | 18 | 13 | 12 | 16 | 21 | 0 | 4 | 1.16 | 3.68 |
| 8t | E. Frieri | LAA | 28 | 0 | 0 | 1 | 15 | 29.0 | 18 | 9 | 9 | 18 | 42 | 1 | 1 | 1.24 | 2.79 |
| 8t | G. Holland | KC | 27 | 0 | 2 | 1 | 15 | 26.0 | 18 | 8 | 6 | 11 | 41 | 1 | 2 | 1.12 | 2.08 |
| 8t | C. Janssen | Tor | 23 | 0 | 1 | 0 | 15 | 22.2 | 13 | 6 | 6 | 4 | 22 | 0 | 1 | 0.75 | 2.38 |
| 11t | F. Rodney | TB | 30 | 0 | 2 | 2 | 14 | 29.1 | 22 | 17 | 17 | 23 | 37 | 0 | 5 | 1.53 | 5.22 |
| 11t | J. Veras | Hou | 31 | 0 | 0 | 4 | 14 | 31.0 | 22 | 14 | 14 | 13 | 36 | 0 | 3 | 1.13 | 4.06 |
| 13 | J. Valverde | Det | 19 | 0 | 0 | 1 | 9 | 18.1 | 13 | 8 | 8 | 6 | 18 | 0 | 3 | 1.04 | 3.93 |
| 14 | A. Bailey | Bos | 22 | 0 | 2 | 0 | 8 | 21.1 | 16 | 7 | 7 | 9 | 30 | 4 | 2 | 1.17 | 2.95 |
| 15 | C. Perez | Cle | 17 | 0 | 2 | 1 | 6 | 16.2 | 15 | 9 | 8 | 10 | 18 | 1 | 2 | 1.50 | 4.32 |
| 16t | J. Benoit | Det | 29 | 0 | 1 | 0 | 4 | 30.0 | 21 | 6 | 6 | 9 | 35 | 9 | 0 | 1.00 | 1.80 |
| 16t | J. Hanrahan | Bos | 9 | 0 | 0 | 1 | 4 | 7.1 | 10 | 8 | 8 | 6 | 5 | 0 | 2 | 2.18 | 9.82 |
| 18t | H. Ambriz | Hou | 33 | 0 | 1 | 3 | 2 | 28.1 | 36 | 20 | 15 | 8 | 21 | 12 | 2 | 1.55 | 4.76 |
| 18t | J. Burton | Min | 31 | 0 | 0 | 4 | 2 | 30.1 | 28 | 13 | 12 | 12 | 30 | 13 | 3 | 1.32 | 3.56 |
| 18t | K. Herrera | KC | 25 | 0 | 3 | 4 | 2 | 24.2 | 20 | 11 | 11 | 11 | 28 | 7 | 1 | 1.26 | 4.01 |
| 18t | A. Loup | Tor | 28 | 0 | 3 | 3 | 2 | 35.2 | 31 | 12 | 8 | 5 | 27 | 4 | 1 | 1.01 | 2.02 |
| 18t | D. Smyly | Det | 24 | 0 | 2 | 0 | 2 | 41.2 | 30 | 9 | 9 | 12 | 42 | 7 | 1 | 1.01 | 1.94 |