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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1t | J. Crain | CWS | 24 | 0 | 1 | 1 | 0 | 21.0 | 15 | 2 | 2 | 8 | 27 | 14 | 0 | 1.10 | 0.86 |
| 1t | J. Peralta | TB | 24 | 0 | 0 | 2 | 1 | 21.2 | 14 | 6 | 5 | 8 | 23 | 12 | 0 | 1.02 | 2.08 |
| 3t | H. Ambriz | Hou | 23 | 0 | 1 | 2 | 0 | 21.2 | 25 | 17 | 13 | 8 | 18 | 8 | 2 | 1.52 | 5.40 |
| 3t | J. Johnson | Bal | 23 | 0 | 2 | 4 | 14 | 22.1 | 22 | 11 | 10 | 6 | 18 | 0 | 3 | 1.25 | 4.03 |
| 3t | W. Wright | Hou | 23 | 0 | 0 | 1 | 0 | 18.2 | 25 | 9 | 8 | 5 | 12 | 3 | 1 | 1.61 | 3.86 |
| 6t | J. Blevins | Oak | 22 | 0 | 3 | 0 | 0 | 22.2 | 14 | 5 | 5 | 1 | 20 | 0 | 2 | 0.66 | 1.99 |
| 6t | D. De La Rosa | LAA | 22 | 0 | 1 | 1 | 0 | 23.0 | 22 | 12 | 12 | 9 | 20 | 6 | 1 | 1.35 | 4.70 |
| 6t | C. Fien | Min | 22 | 0 | 1 | 2 | 0 | 19.1 | 15 | 9 | 9 | 5 | 18 | 3 | 2 | 1.03 | 4.19 |
| 6t | M. Lindstrom | CWS | 22 | 0 | 2 | 2 | 0 | 18.0 | 14 | 9 | 9 | 10 | 15 | 6 | 1 | 1.33 | 4.50 |
| 6t | B. Matusz | Bal | 22 | 0 | 1 | 0 | 0 | 18.1 | 8 | 5 | 5 | 4 | 19 | 7 | 2 | 0.65 | 2.45 |
| 6t | D. O'Day | Bal | 22 | 0 | 2 | 0 | 1 | 21.2 | 16 | 6 | 5 | 9 | 24 | 6 | 2 | 1.15 | 2.08 |
| 12t | J. Burton | Min | 21 | 0 | 0 | 1 | 1 | 20.0 | 16 | 5 | 5 | 9 | 23 | 9 | 1 | 1.25 | 2.25 |
| 12t | B. Cecil | Tor | 21 | 0 | 1 | 0 | 0 | 23.0 | 16 | 6 | 6 | 7 | 24 | 2 | 0 | 1.00 | 2.35 |
| 12t | S. Delabar | Tor | 21 | 0 | 3 | 1 | 0 | 25.0 | 16 | 6 | 5 | 14 | 29 | 1 | 2 | 1.20 | 1.80 |
| 12t | S. Doolittle | Oak | 21 | 0 | 3 | 0 | 0 | 20.0 | 9 | 2 | 2 | 3 | 21 | 8 | 1 | 0.60 | 0.90 |
| 12t | J. McGee | TB | 21 | 0 | 1 | 2 | 0 | 17.0 | 19 | 15 | 15 | 10 | 23 | 9 | 3 | 1.71 | 7.94 |
| 12t | A. Miller | Bos | 21 | 0 | 0 | 1 | 0 | 14.1 | 11 | 6 | 6 | 8 | 25 | 4 | 0 | 1.33 | 3.77 |
| 12t | A. Reed | CWS | 21 | 0 | 1 | 0 | 16 | 21.0 | 14 | 5 | 5 | 8 | 24 | 0 | 1 | 1.05 | 2.14 |
| 12t | E. Rogers | Tor | 21 | 0 | 1 | 2 | 0 | 22.2 | 27 | 13 | 13 | 8 | 12 | 4 | 1 | 1.54 | 5.16 |
| 12t | T. Scheppers | Tex | 21 | 0 | 3 | 0 | 0 | 24.0 | 13 | 2 | 2 | 6 | 15 | 8 | 0 | 0.79 | 0.75 |
| 12t | P. Strop | Bal | 21 | 0 | 0 | 2 | 0 | 17.1 | 13 | 11 | 10 | 12 | 17 | 3 | 2 | 1.44 | 5.19 |
| 12t | M. Thornton | CWS | 21 | 0 | 0 | 1 | 0 | 13.2 | 15 | 8 | 6 | 5 | 7 | 10 | 1 | 1.46 | 3.95 |