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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1t | C. Hamels | Phi | 10 | 10 | 1 | 7 | 0 | 62.2 | 56 | 31 | 31 | 24 | 57 | 0 | 0 | 1.28 | 4.45 |
| 1t | E. Jackson | ChC | 10 | 10 | 1 | 7 | 0 | 53.0 | 61 | 41 | 36 | 22 | 52 | 0 | 0 | 1.57 | 6.11 |
| 3t | J. Samardzija | ChC | 10 | 10 | 2 | 6 | 0 | 63.2 | 50 | 27 | 23 | 22 | 72 | 0 | 0 | 1.13 | 3.25 |
| 3t | A. Sanabia | Mia | 9 | 9 | 3 | 6 | 0 | 51.1 | 63 | 29 | 26 | 24 | 28 | 0 | 0 | 1.69 | 4.56 |
| 5t | J. Beckett | LAD | 8 | 8 | 0 | 5 | 0 | 43.1 | 50 | 30 | 25 | 15 | 41 | 0 | 0 | 1.50 | 5.19 |
| 5t | A. Burnett | Pit | 11 | 11 | 3 | 5 | 0 | 70.0 | 49 | 21 | 20 | 25 | 85 | 0 | 0 | 1.06 | 2.57 |
| 5t | T. Cahill | Ari | 10 | 10 | 3 | 5 | 0 | 64.0 | 51 | 21 | 20 | 24 | 44 | 0 | 0 | 1.17 | 2.81 |
| 5t | J. Garland | Col | 9 | 9 | 3 | 5 | 0 | 52.0 | 66 | 31 | 30 | 15 | 26 | 0 | 0 | 1.56 | 5.19 |
| 5t | D. Gee | NYM | 9 | 9 | 2 | 5 | 0 | 44.2 | 61 | 31 | 30 | 17 | 33 | 0 | 0 | 1.75 | 6.04 |
| 5t | D. Haren | Was | 9 | 9 | 4 | 5 | 0 | 50.1 | 64 | 35 | 31 | 8 | 36 | 0 | 0 | 1.43 | 5.54 |
| 5t | J. Hefner | NYM | 10 | 9 | 0 | 5 | 0 | 51.0 | 45 | 27 | 27 | 20 | 37 | 0 | 0 | 1.27 | 4.76 |
| 5t | W. LeBlanc | Mia | 11 | 7 | 0 | 5 | 0 | 44.0 | 61 | 30 | 28 | 15 | 31 | 0 | 0 | 1.73 | 5.73 |
| 5t | K. Lohse | Mil | 9 | 9 | 1 | 5 | 0 | 55.0 | 60 | 23 | 23 | 10 | 37 | 0 | 0 | 1.27 | 3.76 |
| 5t | S. Marcum | NYM | 6 | 5 | 0 | 5 | 0 | 27.1 | 35 | 21 | 20 | 8 | 20 | 0 | 0 | 1.57 | 6.59 |
| 5t | K. Medlen | Atl | 10 | 10 | 1 | 5 | 0 | 62.2 | 60 | 27 | 22 | 23 | 47 | 0 | 0 | 1.32 | 3.16 |
| 5t | J. Niese | NYM | 10 | 10 | 3 | 5 | 0 | 54.1 | 61 | 36 | 29 | 27 | 31 | 0 | 0 | 1.62 | 4.80 |
| 5t | R. Nolasco | Mia | 10 | 10 | 3 | 5 | 0 | 61.1 | 57 | 28 | 27 | 14 | 50 | 0 | 0 | 1.16 | 3.96 |
| 5t | W. Peralta | Mil | 10 | 10 | 3 | 5 | 0 | 51.2 | 69 | 44 | 37 | 19 | 31 | 0 | 0 | 1.70 | 6.45 |
| 5t | K. Slowey | Mia | 10 | 10 | 1 | 5 | 0 | 57.1 | 58 | 21 | 21 | 12 | 43 | 0 | 0 | 1.22 | 3.30 |
| 5t | S. Strasburg | Was | 10 | 10 | 2 | 5 | 0 | 64.1 | 51 | 28 | 19 | 21 | 62 | 0 | 0 | 1.12 | 2.66 |
| 5t | E. Volquez | SD | 10 | 10 | 3 | 5 | 0 | 54.2 | 61 | 36 | 35 | 25 | 36 | 0 | 0 | 1.57 | 5.76 |