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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | P. Humber | Hou | 9 | 7 | 0 | 8 | 0 | 35.2 | 57 | 38 | 38 | 15 | 20 | 0 | 1 | 2.02 | 9.59 |
| 2t | C. Hamels | Phi | 10 | 10 | 1 | 7 | 0 | 62.2 | 56 | 31 | 31 | 24 | 57 | 0 | 0 | 1.28 | 4.45 |
| 2t | J. Blanton | LAA | 10 | 10 | 1 | 7 | 0 | 56.2 | 93 | 41 | 39 | 13 | 36 | 0 | 0 | 1.87 | 6.19 |
| 2t | E. Jackson | ChC | 10 | 10 | 1 | 7 | 0 | 53.0 | 61 | 41 | 36 | 22 | 52 | 0 | 0 | 1.57 | 6.11 |
| 5t | B. Maurer | Sea | 9 | 9 | 2 | 6 | 0 | 43.2 | 57 | 34 | 33 | 16 | 30 | 0 | 0 | 1.67 | 6.80 |
| 5t | J. Parker | Oak | 10 | 10 | 2 | 6 | 0 | 54.2 | 63 | 36 | 35 | 25 | 40 | 0 | 0 | 1.61 | 5.76 |
| 5t | A. Sanabia | Mia | 9 | 9 | 3 | 6 | 0 | 51.1 | 63 | 29 | 26 | 24 | 28 | 0 | 0 | 1.69 | 4.56 |
| 5t | J. Samardzija | ChC | 10 | 10 | 2 | 6 | 0 | 63.2 | 50 | 27 | 23 | 22 | 72 | 0 | 0 | 1.13 | 3.25 |
| 9t | E. Volquez | SD | 10 | 10 | 3 | 5 | 0 | 54.2 | 61 | 36 | 35 | 25 | 36 | 0 | 0 | 1.57 | 5.76 |
| 9t | V. Worley | Min | 10 | 10 | 1 | 5 | 0 | 48.2 | 82 | 43 | 39 | 15 | 25 | 0 | 0 | 1.99 | 7.21 |
| 9t | J. Garland | Col | 9 | 9 | 3 | 5 | 0 | 52.0 | 66 | 31 | 30 | 15 | 26 | 0 | 0 | 1.56 | 5.19 |
| 9t | R. Hernandez | TB | 9 | 9 | 2 | 5 | 0 | 48.2 | 54 | 34 | 31 | 16 | 45 | 0 | 0 | 1.44 | 5.73 |
| 9t | S. Strasburg | Was | 10 | 10 | 2 | 5 | 0 | 64.1 | 51 | 28 | 19 | 21 | 62 | 0 | 0 | 1.12 | 2.66 |
| 9t | D. Gee | NYM | 9 | 9 | 2 | 5 | 0 | 44.2 | 61 | 31 | 30 | 17 | 33 | 0 | 0 | 1.75 | 6.04 |
| 9t | K. Slowey | Mia | 10 | 10 | 1 | 5 | 0 | 57.1 | 58 | 21 | 21 | 12 | 43 | 0 | 0 | 1.22 | 3.30 |
| 9t | J. Shields | KC | 10 | 10 | 2 | 5 | 0 | 73.0 | 55 | 21 | 20 | 15 | 69 | 0 | 0 | 0.96 | 2.47 |
| 9t | J. Saunders | Sea | 10 | 10 | 3 | 5 | 0 | 57.2 | 73 | 40 | 39 | 22 | 29 | 0 | 0 | 1.65 | 6.09 |
| 9t | J. Beckett | LAD | 8 | 8 | 0 | 5 | 0 | 43.1 | 50 | 30 | 25 | 15 | 41 | 0 | 0 | 1.50 | 5.19 |
| 9t | W. LeBlanc | Mia | 11 | 7 | 0 | 5 | 0 | 44.0 | 61 | 30 | 28 | 15 | 31 | 0 | 0 | 1.73 | 5.73 |
| 9t | J. Hefner | NYM | 10 | 9 | 0 | 5 | 0 | 51.0 | 45 | 27 | 27 | 20 | 37 | 0 | 0 | 1.27 | 4.76 |
| 9t | L. Harrell | Hou | 10 | 10 | 3 | 5 | 0 | 56.1 | 63 | 30 | 29 | 30 | 32 | 0 | 0 | 1.65 | 4.63 |
| 9t | A. Harang | Sea | 6 | 6 | 1 | 5 | 0 | 28.1 | 39 | 27 | 27 | 5 | 27 | 0 | 0 | 1.55 | 8.58 |
| 9t | D. Haren | Was | 9 | 9 | 4 | 5 | 0 | 50.1 | 64 | 35 | 31 | 8 | 36 | 0 | 0 | 1.43 | 5.54 |
| 9t | K. Lohse | Mil | 9 | 9 | 1 | 5 | 0 | 55.0 | 60 | 23 | 23 | 10 | 37 | 0 | 0 | 1.27 | 3.76 |
| 9t | S. Marcum | NYM | 6 | 5 | 0 | 5 | 0 | 27.1 | 35 | 21 | 20 | 8 | 20 | 0 | 0 | 1.57 | 6.59 |
| 9t | R. Dempster | Bos | 10 | 10 | 2 | 5 | 0 | 55.2 | 49 | 33 | 29 | 29 | 67 | 0 | 0 | 1.40 | 4.69 |
| 9t | W. Peralta | Mil | 10 | 10 | 3 | 5 | 0 | 51.2 | 69 | 44 | 37 | 19 | 31 | 0 | 0 | 1.70 | 6.45 |
| 9t | K. Medlen | Atl | 10 | 10 | 1 | 5 | 0 | 62.2 | 60 | 27 | 22 | 23 | 47 | 0 | 0 | 1.32 | 3.16 |
| 9t | R. Dickey | Tor | 10 | 10 | 4 | 5 | 0 | 62.0 | 53 | 35 | 31 | 28 | 53 | 0 | 0 | 1.31 | 4.50 |
| 9t | T. Milone | Oak | 10 | 10 | 4 | 5 | 0 | 64.0 | 64 | 31 | 27 | 12 | 55 | 0 | 0 | 1.19 | 3.80 |
| 9t | T. Cahill | Ari | 10 | 10 | 3 | 5 | 0 | 64.0 | 51 | 21 | 20 | 24 | 44 | 0 | 0 | 1.17 | 2.81 |
| 9t | R. Nolasco | Mia | 10 | 10 | 3 | 5 | 0 | 61.1 | 57 | 28 | 27 | 14 | 50 | 0 | 0 | 1.16 | 3.96 |
| 9t | A. Burnett | Pit | 11 | 11 | 3 | 5 | 0 | 70.0 | 49 | 21 | 20 | 25 | 85 | 0 | 0 | 1.06 | 2.57 |
| 9t | J. Niese | NYM | 10 | 10 | 3 | 5 | 0 | 54.1 | 61 | 36 | 29 | 27 | 31 | 0 | 0 | 1.62 | 4.80 |