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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | P. Humber | Hou | 9 | 7 | 0 | 8 | 0 | 35.2 | 57 | 38 | 38 | 15 | 20 | 0 | 1 | 2.02 | 9.59 |
| 2 | J. Blanton | LAA | 9 | 9 | 0 | 7 | 0 | 50.1 | 86 | 39 | 37 | 13 | 35 | 0 | 0 | 1.97 | 6.62 |
| 3t | B. Maurer | Sea | 9 | 9 | 2 | 6 | 0 | 43.2 | 57 | 34 | 33 | 16 | 30 | 0 | 0 | 1.67 | 6.80 |
| 3t | J. Parker | Oak | 10 | 10 | 2 | 6 | 0 | 54.2 | 63 | 36 | 35 | 25 | 40 | 0 | 0 | 1.61 | 5.76 |
| 5t | R. Dickey | Tor | 10 | 10 | 4 | 5 | 0 | 62.0 | 53 | 35 | 31 | 28 | 53 | 0 | 0 | 1.31 | 4.50 |
| 5t | A. Harang | Sea | 6 | 6 | 1 | 5 | 0 | 28.1 | 39 | 27 | 27 | 5 | 27 | 0 | 0 | 1.55 | 8.58 |
| 5t | L. Harrell | Hou | 10 | 10 | 3 | 5 | 0 | 56.1 | 63 | 30 | 29 | 30 | 32 | 0 | 0 | 1.65 | 4.63 |
| 5t | T. Milone | Oak | 9 | 9 | 4 | 5 | 0 | 57.0 | 56 | 26 | 22 | 12 | 49 | 0 | 0 | 1.19 | 3.47 |
| 5t | J. Shields | KC | 10 | 10 | 2 | 5 | 0 | 73.0 | 55 | 21 | 20 | 15 | 69 | 0 | 0 | 0.96 | 2.47 |
| 5t | V. Worley | Min | 10 | 10 | 1 | 5 | 0 | 48.2 | 82 | 43 | 39 | 15 | 25 | 0 | 0 | 1.99 | 7.21 |
| 11t | B. Anderson | Oak | 6 | 5 | 1 | 4 | 0 | 29.0 | 32 | 22 | 20 | 15 | 29 | 0 | 0 | 1.62 | 6.21 |
| 11t | K. Correia | Min | 9 | 9 | 4 | 4 | 0 | 57.2 | 66 | 25 | 25 | 9 | 22 | 0 | 0 | 1.30 | 3.90 |
| 11t | R. Dempster | Bos | 9 | 9 | 2 | 4 | 0 | 52.2 | 44 | 29 | 25 | 25 | 63 | 0 | 0 | 1.31 | 4.27 |
| 11t | S. Diamond | Min | 7 | 7 | 3 | 4 | 0 | 39.2 | 48 | 23 | 22 | 9 | 16 | 0 | 0 | 1.44 | 4.99 |
| 11t | G. Floyd | CWS | 5 | 5 | 0 | 4 | 0 | 24.1 | 27 | 15 | 14 | 12 | 25 | 0 | 0 | 1.60 | 5.18 |
| 11t | R. Hernandez | TB | 8 | 8 | 2 | 4 | 0 | 44.2 | 48 | 29 | 26 | 13 | 42 | 0 | 0 | 1.37 | 5.24 |
| 11t | K. Herrera | KC | 19 | 0 | 2 | 4 | 2 | 20.1 | 19 | 11 | 11 | 8 | 24 | 4 | 1 | 1.33 | 4.87 |
| 11t | J. Johnson | Bal | 23 | 0 | 2 | 4 | 14 | 22.1 | 22 | 11 | 10 | 6 | 18 | 0 | 3 | 1.25 | 4.03 |
| 11t | N. Jones | CWS | 17 | 0 | 0 | 4 | 0 | 21.1 | 20 | 18 | 15 | 12 | 17 | 2 | 0 | 1.50 | 6.33 |
| 11t | J. Lackey | Bos | 6 | 6 | 2 | 4 | 0 | 32.2 | 32 | 17 | 12 | 8 | 32 | 0 | 0 | 1.22 | 3.31 |
| 11t | B. Norris | Hou | 10 | 10 | 4 | 4 | 0 | 56.0 | 64 | 29 | 24 | 20 | 35 | 0 | 0 | 1.50 | 3.86 |
| 11t | M. Pelfrey | Min | 9 | 9 | 3 | 4 | 0 | 40.1 | 61 | 32 | 30 | 12 | 19 | 0 | 0 | 1.81 | 6.69 |
| 11t | D. Price | TB | 9 | 9 | 1 | 4 | 0 | 55.0 | 65 | 39 | 32 | 14 | 49 | 0 | 0 | 1.44 | 5.24 |
| 11t | A. Sanchez | Det | 9 | 9 | 4 | 4 | 0 | 55.1 | 54 | 20 | 17 | 14 | 68 | 0 | 0 | 1.23 | 2.77 |
| 11t | J. Saunders | Sea | 9 | 9 | 3 | 4 | 0 | 52.2 | 65 | 34 | 33 | 20 | 22 | 0 | 0 | 1.61 | 5.64 |
| 11t | N. Tepesch | Tex | 8 | 8 | 3 | 4 | 0 | 43.0 | 44 | 20 | 19 | 13 | 31 | 0 | 0 | 1.33 | 3.98 |
| 11t | J. Verlander | Det | 10 | 10 | 5 | 4 | 0 | 59.0 | 60 | 26 | 24 | 21 | 69 | 0 | 0 | 1.37 | 3.66 |