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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1t | C. Buchholz | Bos | 12 | 12 | 9 | 0 | 0 | 84.1 | 57 | 16 | 16 | 29 | 81 | 0 | 0 | 1.02 | 1.71 |
| 1t | B. Colon | Oak | 14 | 14 | 9 | 2 | 0 | 90.1 | 89 | 29 | 29 | 10 | 52 | 0 | 0 | 1.10 | 2.89 |
| 1t | M. Scherzer | Det | 13 | 13 | 9 | 0 | 0 | 90.1 | 57 | 33 | 32 | 22 | 106 | 0 | 0 | 0.87 | 3.19 |
| 4t | F. Hernandez | Sea | 15 | 15 | 8 | 4 | 0 | 104.2 | 88 | 30 | 27 | 20 | 110 | 0 | 0 | 1.03 | 2.32 |
| 4t | J. Masterson | Cle | 15 | 15 | 8 | 5 | 0 | 102.1 | 80 | 40 | 40 | 41 | 102 | 0 | 0 | 1.18 | 3.52 |
| 4t | M. Moore | TB | 14 | 14 | 8 | 3 | 0 | 74.1 | 65 | 35 | 34 | 39 | 68 | 0 | 0 | 1.40 | 4.12 |
| 4t | J. Verlander | Det | 14 | 14 | 8 | 4 | 0 | 87.0 | 85 | 35 | 33 | 28 | 101 | 0 | 0 | 1.30 | 3.41 |
| 8t | Y. Darvish | Tex | 14 | 14 | 7 | 2 | 0 | 95.1 | 61 | 29 | 28 | 29 | 127 | 0 | 0 | 0.94 | 2.64 |
| 8t | J. Guthrie | KC | 14 | 14 | 7 | 4 | 0 | 92.0 | 94 | 41 | 38 | 31 | 44 | 0 | 0 | 1.36 | 3.72 |
| 8t | J. Hammel | Bal | 14 | 14 | 7 | 4 | 0 | 80.2 | 91 | 50 | 47 | 29 | 54 | 0 | 0 | 1.49 | 5.24 |
| 8t | H. Iwakuma | Sea | 15 | 15 | 7 | 2 | 0 | 100.1 | 72 | 26 | 23 | 17 | 90 | 0 | 0 | 0.89 | 2.06 |
| 8t | C. Sabathia | NYY | 15 | 15 | 7 | 5 | 0 | 103.0 | 106 | 48 | 45 | 21 | 89 | 0 | 0 | 1.23 | 3.93 |
| 8t | C. Tillman | Bal | 14 | 14 | 7 | 2 | 0 | 82.1 | 76 | 34 | 33 | 29 | 68 | 0 | 0 | 1.28 | 3.61 |
| 14t | A. Cobb | TB | 13 | 13 | 6 | 2 | 0 | 83.2 | 74 | 29 | 28 | 23 | 76 | 0 | 0 | 1.16 | 3.01 |
| 14t | R. Dickey | Tor | 15 | 15 | 6 | 8 | 0 | 93.2 | 92 | 55 | 51 | 38 | 67 | 0 | 0 | 1.39 | 4.90 |
| 14t | D. Fister | Det | 14 | 14 | 6 | 4 | 0 | 92.2 | 90 | 38 | 33 | 14 | 76 | 0 | 0 | 1.12 | 3.21 |
| 14t | H. Kuroda | NYY | 14 | 14 | 6 | 5 | 0 | 87.1 | 72 | 27 | 27 | 19 | 60 | 0 | 0 | 1.04 | 2.78 |
| 14t | J. Lester | Bos | 15 | 15 | 6 | 4 | 0 | 94.2 | 92 | 48 | 46 | 33 | 80 | 0 | 0 | 1.32 | 4.37 |
| 14t | T. Milone | Oak | 14 | 14 | 6 | 6 | 0 | 89.2 | 86 | 40 | 36 | 19 | 73 | 0 | 0 | 1.17 | 3.61 |
| 14t | J. Peavy | CWS | 11 | 11 | 6 | 4 | 0 | 67.0 | 63 | 33 | 32 | 15 | 66 | 0 | 0 | 1.16 | 4.30 |
| 14t | A. Sanchez | Det | 13 | 13 | 6 | 5 | 0 | 81.2 | 71 | 28 | 25 | 23 | 101 | 0 | 0 | 1.15 | 2.76 |