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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | C. Buchholz | Bos | 9 | 9 | 6 | 0 | 0 | 65.2 | 44 | 13 | 13 | 24 | 69 | 0 | 0 | 1.04 | 1.78 |
| 2 | H. Iwakuma | Sea | 9 | 9 | 5 | 1 | 0 | 58.2 | 38 | 14 | 12 | 8 | 55 | 0 | 0 | 0.78 | 1.84 |
| 3 | H. Kuroda | NYY | 9 | 9 | 6 | 2 | 0 | 58.2 | 42 | 13 | 13 | 14 | 39 | 0 | 0 | 0.95 | 1.99 |
| 4 | F. Hernandez | Sea | 10 | 10 | 5 | 3 | 0 | 69.2 | 58 | 19 | 16 | 12 | 72 | 0 | 0 | 1.00 | 2.07 |
| 5 | M. Moore | TB | 9 | 9 | 8 | 0 | 0 | 55.0 | 34 | 14 | 14 | 26 | 54 | 0 | 0 | 1.09 | 2.29 |
| 6 | J. Shields | KC | 9 | 9 | 2 | 4 | 0 | 66.0 | 48 | 19 | 18 | 15 | 62 | 0 | 0 | 0.95 | 2.45 |
| 7 | C. Sale | CWS | 9 | 9 | 5 | 2 | 0 | 64.0 | 44 | 19 | 18 | 15 | 61 | 0 | 0 | 0.92 | 2.53 |
| 8 | Z. McAllister | Cle | 8 | 8 | 3 | 3 | 0 | 51.0 | 46 | 20 | 15 | 14 | 34 | 0 | 0 | 1.18 | 2.65 |
| 9 | J. Lester | Bos | 9 | 9 | 6 | 0 | 0 | 59.2 | 45 | 19 | 18 | 15 | 50 | 0 | 0 | 1.01 | 2.72 |
| 10t | A. Sanchez | Det | 9 | 9 | 4 | 4 | 0 | 55.1 | 54 | 20 | 17 | 14 | 68 | 0 | 0 | 1.23 | 2.77 |
| 10t | E. Santana | KC | 8 | 8 | 3 | 3 | 0 | 55.1 | 51 | 18 | 17 | 9 | 44 | 0 | 0 | 1.08 | 2.77 |
| 12 | J. Guthrie | KC | 8 | 8 | 5 | 1 | 0 | 54.1 | 53 | 18 | 17 | 17 | 30 | 0 | 0 | 1.29 | 2.82 |
| 13 | J. Masterson | Cle | 10 | 10 | 7 | 2 | 0 | 70.0 | 53 | 22 | 22 | 26 | 71 | 0 | 0 | 1.13 | 2.83 |
| 14 | A. Cobb | TB | 8 | 8 | 4 | 2 | 0 | 53.0 | 50 | 18 | 17 | 12 | 52 | 0 | 0 | 1.17 | 2.89 |
| 15 | Y. Darvish | Tex | 9 | 9 | 7 | 1 | 0 | 60.2 | 37 | 20 | 20 | 19 | 86 | 0 | 0 | 0.92 | 2.97 |
| 16 | W. Chen | Bal | 8 | 8 | 3 | 3 | 0 | 47.1 | 45 | 16 | 16 | 12 | 27 | 0 | 0 | 1.20 | 3.04 |
| 17 | A. Ogando | Tex | 9 | 9 | 4 | 2 | 0 | 49.2 | 43 | 19 | 17 | 19 | 37 | 0 | 0 | 1.25 | 3.08 |
| 18 | J. Verlander | Det | 9 | 9 | 4 | 4 | 0 | 54.0 | 50 | 21 | 19 | 20 | 60 | 0 | 0 | 1.30 | 3.17 |
| 19 | C. Sabathia | NYY | 9 | 9 | 4 | 3 | 0 | 59.1 | 61 | 24 | 21 | 15 | 54 | 0 | 0 | 1.28 | 3.19 |
| 20 | D. Holland | Tex | 9 | 9 | 3 | 2 | 0 | 60.0 | 56 | 23 | 22 | 14 | 54 | 0 | 0 | 1.17 | 3.30 |