Transactions
| Date | Player | Pos | Transactions |
| 2/3 | David Sharpe | T | signed |
| 1/23 | Tarik Black | WR | pract. squad del |
| 1/23 | Nick Boyle | TE | pract. squad del |
| 1/23 | Josh Bynes | LB | pract. squad del |
| 1/23 | Brett Hundley | QB | pract. squad del |
| 1/23 | Kahlil McKenzie | G | pract. squad del |
| 1/23 | David Sharpe | T | pract. squad del |
| 1/23 | Binjimen Victor | WR | pract. squad del |
| 1/23 | Trayvon Mullen Jr. | CB | acquired from waiver |
| 1/19 | Andy Isabella | WR | signed |
| 1/18 | Ben Mason | RB | signed |
| 1/16 | Andy Isabella | WR | pract. squad add |
| 1/16 | Binjimen Victor | WR | pract. squad add |
| 1/16 | Shemar Bridges | WR | signed |
| 1/16 | BoPete Keyes | CB | signed |
| 1/16 | Jeremiah Moon | LB | signed |
| 1/16 | Rayshad Nichols | DT | signed |
| 1/16 | John Simpson | G | signed |
| 1/16 | Mike Thomas | WR | signed |
| 1/14 | Andy Isabella | WR | active/prac. squad |
| 1/14 | Binjimen Victor | WR | active/prac. squad |
| 1/14 | Ar'Darius Washington | S | active/prac. squad |
| 1/14 | Tylan Wallace | WR | on IR hamstring |
| 1/10 | Roquan Smith | LB | re-signed Five-year extension (through 2027) |
| 1/10 | Nick Boyle | TE | pract. squad add |
| 1/10 | Christian Ringo | DT | pract. squad del |
| 1/9 | Brett Hundley | QB | pract. squad add |
| 1/9 | Rayshad Nichols | DT | pract. squad add |
| 1/7 | Nick Boyle | TE | cut |
| 1/7 | DeSean Jackson | WR | cut |
| 1/7 | Brett Hundley | QB | active/prac. squad |
| 1/7 | Rayshad Nichols | DT | active/prac. squad |
| 1/3 | Tarik Black | WR | pract. squad add |
| 1/2 | Andy Isabella | WR | pract. squad add |
| 1/2 | Rayshad Nichols | DT | pract. squad add |
| 12/31 | Anthony Brown | QB | active/prac. squad |
| 12/31 | Andy Isabella | WR | active/prac. squad |
| 12/31 | Rayshad Nichols | DT | active/prac. squad |
| 12/28 | Christian Ringo | DT | pract. squad add |
| 12/27 | Josh Bynes | LB | pract. squad add |
| 12/26 | Isaiah Mack | DT | cut |
| 12/25 | Anthony Brown | QB | pract. squad add |
| 12/25 | Andy Isabella | WR | pract. squad add |
| 12/23 | Josh Bynes | LB | cut |
| 12/23 | Anthony Brown | QB | active/prac. squad |
| 12/23 | Andy Isabella | WR | active/prac. squad |
| 12/23 | Isaiah Mack | DT | active/prac. squad |
| 12/20 | Sammy Watkins | WR | acquired from waiver |
| 12/20 | Mike Thomas | WR | pract. squad add |
| 12/20 | Zack Johnson | G | pract. squad del |
| 12/20 | Devin Duvernay | WR | on IR broken foot |
| 12/19 | John Simpson | G | pract. squad add |
| 12/19 | Julian Stanford | LB | pract. squad del |
| 12/18 | Anthony Brown | QB | pract. squad add |
| 12/16 | Anthony Brown | QB | active/prac. squad |
| 12/12 | Anthony Brown | QB | pract. squad add |
| 12/12 | Ar'Darius Washington | S | pract. squad add |
| 12/10 | Mike Davis | RB | cut |
| 12/10 | Anthony Brown | QB | active/prac. squad |
| 12/10 | Ar'Darius Washington | S | active/prac. squad |
| 12/7 | BoPete Keyes | CB | pract. squad add |
| 12/7 | Binjimen Victor | WR | pract. squad add |
| 12/6 | DeSean Jackson | WR | active/prac. squad |
| 12/5 | DeSean Jackson | WR | pract. squad add |
| 12/5 | Ar'Darius Washington | S | pract. squad add |
| 12/5 | Brett Hundley | QB | pract. squad add |
| 12/5 | Devon Kennard | LB | pract. squad del |
| 12/5 | Binjimen Victor | WR | cut |
| 12/3 | DeSean Jackson | WR | active/prac. squad |
| 12/3 | Ar'Darius Washington | S | active/prac. squad |
| 12/3 | Binjimen Victor | WR | active/prac. squad |
| 11/30 | Shemar Bridges | WR | pract. squad add |
| 11/28 | DeSean Jackson | WR | pract. squad add |
| 11/28 | Julian Stanford | LB | pract. squad add |
| 11/26 | DeSean Jackson | WR | active/prac. squad |
| 11/26 | Julian Stanford | LB | active/prac. squad |
| 11/26 | Daryl Worley | CB | active/prac. squad |
| 11/26 | Jalyn Armour-Davis | CB | on IR hip |
| 11/21 | Daryl Worley | CB | pract. squad add |
| 11/19 | Daryl Worley | CB | active/prac. squad |
| 11/17 | Ed Dickson | TE | retired |
| 11/8 | DeSean Jackson | WR | pract. squad add |
| 11/8 | Binjimen Victor | WR | pract. squad add |
| 11/7 | DeSean Jackson | WR | active/prac. squad |
| 11/7 | Binjimen Victor | WR | active/prac. squad |
| 11/7 | Rashod Bateman | WR | on IR Lisfranc surgery |
| 11/1 | Tyus Bowser | LB | Activated from PUPL |
| 11/1 | David Ojabo | LB | reinstated |
| 11/1 | Daryl Worley | CB | pract. squad add |
| 10/31 | Roquan Smith | LB | traded for LB A.J. Klein and 2023 draft picks |
| 10/31 | Daryl Worley | CB | cut |
| 10/28 | Devon Kennard | LB | pract. squad add |
| 10/28 | Isaiah Mack | DT | pract. squad add |
| 10/27 | Devon Kennard | LB | active/prac. squad |
| 10/27 | Isaiah Mack | DT | active/prac. squad |
| 10/27 | Daryl Worley | CB | active/prac. squad |
| 10/25 | Daryl Worley | CB | pract. squad add |
| 10/24 | Devon Kennard | LB | pract. squad add |
| 10/24 | Daryl Worley | CB | cut |
| 10/22 | Gus Edwards | RB | Activated from PUPL |
| 10/22 | Devon Kennard | LB | active/prac. squad |
| 10/22 | Daryl Worley | CB | active/prac. squad |
| 10/19 | DeSean Jackson | WR | pract. squad add |
| 10/18 | Devon Kennard | LB | pract. squad add |
| 10/18 | Brandon Copeland | LB | pract. squad del |
| 10/18 | Julian Stanford | LB | pract. squad add |
| 10/18 | Jeremiah Attaochu | LB | pract. squad del |
| 10/18 | Slade Bolden | WR | cut |
| 10/18 | Slade Bolden | WR | off IR undisclosed |
| 10/17 | Jeremiah Attaochu | LB | pract. squad add |
| 10/17 | Ar'Darius Washington | S | pract. squad add |
| 10/15 | Jeremiah Attaochu | LB | active/prac. squad |
| 10/15 | Ar'Darius Washington | S | active/prac. squad |
| 10/12 | Daryl Worley | CB | pract. squad add |
| 10/11 | Daryl Worley | CB | cut |
| 10/10 | Brandon Copeland | LB | pract. squad add |
| 10/10 | Andy Isabella | WR | pract. squad add |
| 10/10 | Bailey Gaither | WR | pract. squad del |
| 10/8 | Brandon Copeland | LB | active/prac. squad |
| 10/8 | Daryl Worley | CB | active/prac. squad |
| 10/6 | A.J. Klein | LB | active/prac. squad |
| 10/5 | Bailey Gaither | WR | pract. squad add |
| 10/3 | Jimmy Smith | CB | retired |
| 10/3 | Brandon Copeland | LB | pract. squad add |
| 10/3 | David Sharpe | T | pract. squad add |
| 10/1 | Kevon Seymour | CB | active/prac. squad |
| 10/1 | Brandon Copeland | LB | active/prac. squad |
| 10/1 | David Sharpe | T | active/prac. squad |
| 9/29 | Michael Pierce | DT | on IR torn left biceps |
| 9/28 | Daryl Worley | CB | pract. squad add |
| 9/27 | Daryl Worley | CB | cut |
| 9/27 | Jeremiah Attaochu | LB | pract. squad add |
| 9/27 | Zack Johnson | G | pract. squad add |
| 9/27 | T.J. Carrie | CB | pract. squad del |
| 9/27 | Makai Polk | WR | pract. squad del |
| 9/26 | Jason Pierre-Paul | LB | signed/unrest FA One-year contract (through 2022) |
| 9/26 | Brandon Copeland | LB | pract. squad add |
| 9/26 | Raleigh Webb | WR | pract. squad add |
| 9/24 | Brandon Copeland | LB | active/prac. squad |
| 9/24 | Raleigh Webb | WR | active/prac. squad |
| 9/21 | Brandon Copeland | LB | pract. squad add |
| 9/19 | Raleigh Webb | WR | pract. squad add |
| 9/19 | Kyler Fackrell | LB | pract. squad del |
| 9/19 | Josh Ross | LB | on IR foot |
| 9/19 | Steven Means | LB | on IR torn Achilles |
| 9/17 | Raleigh Webb | WR | active/prac. squad |
| 9/17 | Daryl Worley | CB | active/prac. squad |
| 9/14 | T.J. Carrie | CB | pract. squad add |
| 9/14 | Steven Means | LB | active/prac. squad |
| 9/13 | Kyle Fuller | CB | on IR torn left ACL |
| 9/13 | Ja'Wuan James | T | on IR torn left Achilles |
| 9/12 | Steven Means | LB | pract. squad add |
| 9/10 | Steven Means | LB | active/prac. squad |
| 9/7 | Kyler Fackrell | LB | pract. squad add |
| 9/5 | Shemar Bridges | WR | cut |
| 9/5 | Shemar Bridges | WR | off IR undisclosed |
| 9/1 | Aaron Crawford | DT | cut |
| 9/1 | Aaron Crawford | DT | off IR undisclosed |
| 8/31 | Del'Shawn Phillips | LB | acquired from waiver |
| 8/31 | Tyre Phillips | T | cut |
| 8/31 | Tyler Badie | RB | pract. squad add |
| 8/31 | Anthony Brown | QB | pract. squad add |
| 8/31 | Isaiah Mack | DT | pract. squad add |
| 8/31 | Ben Mason | RB | pract. squad add |
| 8/31 | Kahlil McKenzie | G | pract. squad add |
| 8/31 | Steven Means | LB | pract. squad add |
| 8/31 | Jeremiah Moon | LB | pract. squad add |
| 8/31 | Rayshad Nichols | DT | pract. squad add |
| 8/31 | Makai Polk | WR | pract. squad add |
| 8/31 | Kevon Seymour | CB | pract. squad add |
| 8/31 | David Sharpe | T | pract. squad add |
| 8/31 | Binjimen Victor | WR | pract. squad add |
| 8/31 | Ar'Darius Washington | S | pract. squad add |
| 8/31 | Raleigh Webb | WR | pract. squad add |
| 8/31 | Daryl Worley | CB | pract. squad add |
| 8/31 | Kenyan Drake | RB | signed |
| 8/31 | Brent Urban | DE | signed |
| 8/31 | David Ojabo | LB | reserve/non football injury torn left Achilles tendon |
| 8/31 | Shemar Bridges | WR | on IR undisclosed |
| 8/31 | Aaron Crawford | DT | on IR undisclosed |
| 8/31 | Daelin Hayes | LB | on IR undisclosed |
| 8/30 | Isaiah Mack | DT | cut |
| 8/30 | Tyler Badie | RB | cut |
| 8/30 | Anthony Brown | QB | cut |
| 8/30 | Ben Mason | RB | cut |
| 8/30 | Zakoby McClain | LB | cut |
| 8/30 | Nate McCrary | RB | cut |
| 8/30 | Jeremiah Moon | LB | cut |
| 8/30 | Rayshad Nichols | DT | cut |
| 8/30 | Tony Poljan | TE | cut |
| 8/30 | Makai Polk | WR | cut |
| 8/30 | David Vereen | CB | cut |
| 8/30 | Binjimen Victor | WR | cut |
| 8/30 | Ar'Darius Washington | S | cut |
| 8/30 | Raleigh Webb | WR | cut |
| 8/30 | Chuck Wiley | LB | cut |
| 8/30 | Kahlil McKenzie | G | cut |
| 8/30 | Steven Means | LB | cut |
| 8/30 | Kevon Seymour | CB | cut |
| 8/30 | David Sharpe | T | cut |
| 8/30 | Brent Urban | DE | cut |
| 8/30 | Daryl Worley | CB | cut |
| 8/29 | Jimmy Murray | C | cut |
| 8/29 | Tony Jefferson II | S | cut |
| 8/28 | Cameron Dicker | K | cut |
| 8/26 | Cameron Dicker | K | signed |
| 8/26 | Tyus Bowser | LB | Placed on PUPL Achilles |
| 8/25 | Trent Harris | DE | cut |
| 8/25 | Trent Harris | DE | off IR undisclosed |
| 8/24 | Slade Bolden | WR | on IR undisclosed |
| 8/23 | Demarcus Robinson | WR | signed |
| 8/23 | Bailey Gaither | WR | cut |
| 8/23 | Diego Fagot | LB | cut |
| 8/23 | Jaryd Jones-Smith | T | cut |
| 8/23 | Gus Edwards | RB | Placed on PUPL knee |
| 8/22 | Jaylon Moore | WR | cut |
| 8/16 | Brett Hundley | QB | cut |
| 8/16 | Trent Harris | DE | on IR undisclosed |
| 8/15 | Corey Clement | RB | cut |
| 8/15 | Robert Jackson | CB | cut |
| 8/13 | Trent Harris | DE | signed |
| 8/13 | Devon Williams | WR | cut |
| 8/13 | Denzel Williams | CB | cut |
| 8/8 | Daryl Worley | CB | signed |
| 8/8 | Justin Tucker | K | re-signed Four-year extension (through 2027) |
| 8/8 | Vince Biegel | LB | on IR torn right Achilles tendon |
| 8/3 | Trevon Clark | WR | cut |
| 8/3 | David Ojabo | LB | signed/draft choice Four-year contract (through 2025) |
| 7/29 | Derek Wolfe | DE | retired |
| 7/27 | Bailey Gaither | WR | signed |
| 7/26 | Corey Clement | RB | signed/unrest FA |
| 7/23 | Devon Williams | WR | reinstated |
| 7/23 | Iman Marshall | CB | cut |
| 7/21 | David Sharpe | T | re-signed/unrest FA |
| 7/20 | Devon Williams | WR | reserve/DNR |
| 7/20 | Ricky Person Jr. | RB | reserve/left camp |
| 7/19 | Daniel Faalele | T | signed/draft choice Four-year contract (through 2025) |
| 7/19 | Jalyn Armour-Davis | CB | signed/draft choice Four-year contract (through 2025) |
| 7/13 | Justin Houston | LB | re-signed/unrest FA One-year contract (through 2022) |
| 6/17 | Steven Means | LB | signed/unrest FA |
| 6/14 | Derek Wolfe | DE | cut |
| 6/13 | Jordan Stout | P | signed/draft choice Four-year contract (through 2025) |
| 6/9 | Charlie Kolar | TE | signed/draft choice Four-year contract (through 2025) |
| 6/7 | Damarion Williams | CB | signed/draft choice Four-year contract (through 2025) |
| 6/7 | Kyle Hamilton | S | signed/draft choice Four-year contract (fifth-year option) |
| 6/6 | Isaiah Likely | TE | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Tyler Linderbaum | C | signed/draft choice Four-year contract (fifth-year option) |
| 5/31 | Aron Johnson | T | cut |
| 5/26 | Brett Hundley | QB | signed |
| 5/26 | Kevin Toliver II | CB | cut |
| 5/24 | Kyle Fuller | CB | signed/unrest FA One-year contract (through 2022) |
| 5/23 | Diego Fagot | LB | signed |
| 5/23 | Brent Urban | DE | signed/unrest FA One-year contract (through 2022) |
| 5/23 | Chris Moore | S | cut |
| 5/20 | Travis Jones | DT | signed/draft choice Four-year contract (through 2025) |
| 5/19 | Sam Koch | P | retired |
| 5/16 | Vince Biegel | LB | signed/unrest FA One-year contract (through 2022) |
| 5/11 | Xavier Kelly | DT | cut |
| 5/10 | Ty'Son Williams | RB | Declared Free Agent |
| 5/10 | Mike Davis | RB | signed One-year contract (through 2022) |
| 5/6 | Shemar Bridges | WR | signed |
| 5/6 | Anthony Brown | QB | signed |
| 5/6 | Trevon Clark | WR | signed |
| 5/6 | Aron Johnson | T | signed |
| 5/6 | Zakoby McClain | LB | signed |
| 5/6 | Jeremiah Moon | LB | signed |
| 5/6 | Rayshad Nichols | DT | signed |
| 5/6 | Chris Moore | S | signed |
| 5/6 | Makai Polk | WR | signed |
| 5/6 | Josh Ross | LB | signed |
| 5/6 | David Vereen | CB | signed |
| 5/6 | Raleigh Webb | WR | signed |
| 5/6 | Chuck Wiley | LB | signed |
| 5/6 | Denzel Williams | CB | signed |
| 5/6 | Devon Williams | WR | signed |
| 5/6 | Slade Bolden | WR | signed |
| 5/6 | Ricky Person Jr. | RB | signed |
| 5/5 | Tyler Badie | RB | signed/draft choice Four-year contract (through 2025) |
| 4/18 | Trystan Colon | C | re-signed/excl. FA One-year contract (through 2022) |
| 4/18 | Tyler Huntley | QB | re-signed/excl. FA One-year contract (through 2022) |
| 4/18 | Nick Moore | C | re-signed/excl. FA One-year contract (through 2022) |
| 4/18 | Kristian Welch | LB | re-signed/excl. FA One-year contract (through 2022) |
| 4/18 | Miles Boykin | WR | cut |
| 4/15 | Calais Campbell | DE | re-signed/unrest FA Two-year contract (through 2023) |
| 4/13 | Josh Bynes | LB | re-signed/unrest FA One-year contract (through 2022) |
| 4/6 | Geno Stone | S | re-signed/excl. FA One-year contract (through 2022) |
| 3/24 | Patrick Ricard | RB | re-signed/unrest FA Three-year contract (through 2024) |
| 3/23 | Michael Pierce | DT | signed Three-year contract (through 2024) |
| 3/17 | Marcus Williams | S | signed/unrest FA Five-year contract (through 2026) |
| 3/17 | Morgan Moses | T | signed/unrest FA Three-year contract (through 2024) |
| 3/16 | Anthony Averett | CB | Declared Free Agent |
| 3/16 | Chris Board | LB | Declared Free Agent |
| 3/16 | Bradley Bozeman | C | Declared Free Agent |
| 3/16 | Josh Bynes | LB | Declared Free Agent |
| 3/16 | Calais Campbell | DE | Declared Free Agent |
| 3/16 | DeShon Elliott | S | Declared Free Agent |
| 3/16 | Justin Ellis | DT | Declared Free Agent |
| 3/16 | L.J. Fort | LB | Declared Free Agent |
| 3/16 | Devonta Freeman | RB | Declared Free Agent |
| 3/16 | Justin Houston | LB | Declared Free Agent |
| 3/16 | Josh Johnson | QB | Declared Free Agent |
| 3/16 | Pernell McPhee | LB | Declared Free Agent |
| 3/16 | Latavius Murray | RB | Declared Free Agent |
| 3/16 | Patrick Ricard | RB | Declared Free Agent |
| 3/16 | David Sharpe | T | Declared Free Agent |
| 3/16 | Jimmy Smith | CB | Declared Free Agent |
| 3/16 | Eric Tomlinson | TE | Declared Free Agent |
| 3/16 | Sammy Watkins | WR | Declared Free Agent |
| 3/16 | Brandon Williams | DT | Declared Free Agent |
| 3/16 | Otaro Alaka | LB | Declared Free Agent |
| 3/16 | Khalil Dorsey | CB | Declared Free Agent |
| 3/16 | Chris Westry | CB | Declared Free Agent |
| 3/16 | Brandon Knight | T | Declared Free Agent |
| 3/9 | Alejandro Villanueva | T | retired |
| 3/9 | Aaron Crawford | DT | re-signed One-year contract (through 2022) |
| 3/9 | Tavon Young | CB | cut |
| 2/24 | Tony Jefferson II | S | re-signed |
| 2/15 | Brandon Knight | T | reinstated |
| 2/15 | Ja'Wuan James | T | reinstated |
Last updated Feb. 7, 1:10 A.M. ET
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