Injuries
| Date | Player | Status |
| 11/30 | D. Jackson | groin (IR) |
| 11/30 | C. McCaffrey | ankle (IR) |
| 11/28 | J. Miller | ankle (Out) |
| 11/20 | S. Thomas-Oliver III | toe (IR) |
| 11/14 | B. Burns | foot (Questionable) |
| 11/14 | F. Luvu | knee (Questionable) |
| 11/14 | S. Thomas-Oliver III | toe (Out) |
| 11/14 | R. Melvin | hand (Out) |
| 11/12 | S. Darnold | right shoulder (IR) |
| 11/8 | M. Paradis | torn left ACL (IR) |
| 11/8 | C. Erving | calf (Injured-Reserve (DFR)) |
| 11/7 | S. Darnold | concussion, right shoulder (Questionable) |
| 11/7 | S. Thomas-Oliver III | toe (Questionable) |
| 11/7 | P. Elflein | hamstring (Questionable) |
| 10/31 | C. Henderson | shoulder (Questionable) |
| 10/31 | S. Thompson | foot (Questionable) |
| 10/31 | T. Marshall Jr. | concussion (Out) |
| 10/30 | D. Johnson | hamstring (Injured-Reserve (DFR)) |
| 10/28 | D. Nixon | knee (IR) |
| 10/26 | J. Miller | ankle (Injured-Reserve (DFR)) |
| 10/24 | A. Erickson | concussion (Questionable) |
| 10/24 | T. Marshall Jr. | concussion (Out) |
| 10/24 | S. Thompson | foot (Out) |
| 10/24 | G. Ricci | concussion (Out) |
| 10/24 | C. Erving | neck, illness (Out) |
| 10/19 | B. Zylstra | hamstring (Injured-Reserve (DFR)) |
| 10/17 | K. Martin | concussion (Out) |
| 10/17 | S. Thompson | foot (Out) |
| 10/17 | C. Henderson | shoulder (Questionable) |
| 10/16 | C. McCaffrey | hamstring (Injured-Reserve (DFR)) |
| 10/16 | D. Brown | knee (Injured-Reserve (DFR)) |
| 10/14 | J. Charlton | back (Injured-Reserve (DFR)) |
| 10/10 | S. Thompson | foot (Out) |
| 10/10 | C. Erving | neck (Out) |
| 10/10 | C. McCaffrey | hamstring (Doubtful) |
| 10/10 | Y. Gross-Matos | ankle (Questionable) |
| 10/3 | C. McCaffrey | hamstring (Out) |
| 10/3 | Y. Gross-Matos | ankle (Doubtful) |
| 10/3 | J. Miller | shoulder (Questionable) |
| 9/28 | J. Burris | groin (Injured-Reserve (DFR)) |
| 9/27 | J. Horn | broken right foot (IR) |
| 9/26 | C. Henderson | groin, illness (Questionable) |
| 9/23 | Y. Gross-Matos | ankle (Out) |
| 9/21 | P. Elflein | hamstring (Injured-Reserve (DFR)) |
| 9/13 | M. Hartsfield | wrist surgery (Injured-Reserve (DFR)) |
| 9/12 | S. Smith | shoulder (Out) |
| 8/31 | T. Fletcher | hip (IR) |
| 8/27 | T. Hester | back (IR) |
| 8/19 | M. Kaskey | undisclosed (IR) |
| 8/19 | M. Panasiuk | undisclosed (IR) |
| 8/17 | D. Moore | undisclosed (IR) |
| 8/17 | T. Pride Jr. | knee (IR) |
| 6/4 | K. Hogan | undisclosed (IR) |
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