Transactions
| Date | Player | Pos | Transactions |
| 10/4 | Tevin Coleman | RB | pract. squad add |
| 10/4 | Malik Turner | WR | pract. squad add |
| 10/4 | Willie Snead IV | WR | cut |
| 10/3 | Willie Snead IV | WR | active/prac. squad |
| 10/3 | Tevin Coleman | RB | active/prac. squad |
| 10/3 | Malik Turner | WR | active/prac. squad |
| 10/3 | Azeez Al-Shaair | LB | on IR knee |
| 9/26 | Akeem Spence | DT | pract. squad add |
| 9/24 | Akeem Spence | DT | active/prac. squad |
| 9/21 | Marlon Mack | RB | active/prac. squad |
| 9/21 | Kurt Benkert | QB | pract. squad add |
| 9/21 | Tevin Coleman | RB | pract. squad add |
| 9/21 | Trey Lance | QB | on IR broken right ankle |
| 9/20 | Kary Vincent Jr. | CB | pract. squad del |
| 9/19 | Dre Greenlaw | LB | re-signed Two-year extension (through 2024) |
| 9/16 | Mitch Wishnowsky | P | re-signed Four-year extension (through 2026) |
| 9/14 | Kemoko Turay | DE | active/prac. squad |
| 9/14 | Marlon Mack | RB | pract. squad add |
| 9/14 | Willie Snead IV | WR | pract. squad add |
| 9/14 | Kary Vincent Jr. | CB | pract. squad add |
| 9/14 | Jordan Willis | DE | on IR knee |
| 9/13 | Tashaun Gipson Sr. | S | active/prac. squad |
| 9/13 | Keith Ismael | C | pract. squad add |
| 9/13 | Keaton Sutherland | G | pract. squad del |
| 9/13 | Connor Wedington | WR | pract. squad del |
| 9/13 | Elijah Mitchell | RB | on IR sprained right MCL |
| 9/12 | Tashaun Gipson Sr. | S | pract. squad add |
| 9/12 | Malik Turner | WR | pract. squad add |
| 9/10 | Tashaun Gipson Sr. | S | active/prac. squad |
| 9/10 | Malik Turner | WR | active/prac. squad |
| 9/7 | Troy Fumagalli | TE | pract. squad add |
| 9/7 | Connor Wedington | WR | pract. squad add |
| 9/7 | Willie Snead IV | WR | pract. squad del |
| 9/5 | Buddy Johnson | LB | pract. squad add |
| 9/5 | Leroy Watson | T | pract. squad add |
| 9/1 | Dontae Johnson | CB | pract. squad add |
| 8/31 | Blake Hance | G | acquired from waiver |
| 8/31 | Trey Sermon | RB | cut |
| 8/31 | Alex Barrett | DE | pract. squad add |
| 8/31 | Tashaun Gipson Sr. | S | pract. squad add |
| 8/31 | Alfredo Gutierrez | G | pract. squad add International Player Pathway Program |
| 8/31 | Tayler Hawkins | S | pract. squad add |
| 8/31 | Qwuantrezz Knight | CB | pract. squad add |
| 8/31 | Tay Martin | WR | pract. squad add |
| 8/31 | Marcelino McCrary-Ball | LB | pract. squad add |
| 8/31 | Jason Poe | G | pract. squad add |
| 8/31 | Willie Snead IV | WR | pract. squad add |
| 8/31 | Tyler Kroft | TE | signed |
| 8/31 | Akeem Spence | DT | pract. squad add |
| 8/31 | Keaton Sutherland | G | pract. squad add |
| 8/31 | Jordan Willis | DE | signed |
| 8/31 | Kemoko Turay | DE | pract. squad add |
| 8/31 | Malik Turner | WR | pract. squad add |
| 8/31 | Sam Schlueter | T | cut |
| 8/31 | Sam Schlueter | T | off IR undisclosed |
| 8/31 | Curtis Robinson | LB | on IR high ankle sprain |
| 8/31 | Jimmie Ward | S | on IR hamstring |
| 8/30 | Marcus Johnson | WR | cut |
| 8/30 | Willie Snead IV | WR | cut |
| 8/30 | Jason Poe | G | cut |
| 8/30 | Alfredo Gutierrez | G | cut |
| 8/30 | Tay Martin | WR | cut |
| 8/30 | Tariq Castro-Fields | CB | cut |
| 8/30 | Jordan Mills | T | cut |
| 8/30 | Qwuantrezz Knight | CB | cut |
| 8/30 | Dontae Johnson | CB | cut |
| 8/30 | Kemoko Turay | DE | cut |
| 8/30 | Malik Turner | WR | cut |
| 8/30 | Nate Sudfeld | QB | cut |
| 8/30 | Troy Fumagalli | TE | cut |
| 8/30 | Tyler Kroft | TE | cut |
| 8/30 | Akeem Spence | DT | cut |
| 8/30 | Jordan Willis | DE | cut |
| 8/30 | Kevin Atkins | DT | cut |
| 8/30 | Alex Barrett | DE | cut |
| 8/30 | JaMycal Hasty | RB | cut |
| 8/30 | Tayler Hawkins | S | cut |
| 8/30 | Marcelino McCrary-Ball | LB | cut |
| 8/30 | Segun Olubi | LB | cut |
| 8/30 | Justin Skule | T | cut |
| 8/30 | Keaton Sutherland | G | cut |
| 8/30 | Tashaun Gipson Sr. | S | cut |
| 8/29 | Ken Crawley | CB | cut |
| 8/29 | Dohnovan West | C | cut |
| 8/28 | Ka'dar Hollman | CB | cut |
| 8/27 | Austin Mack | WR | cut |
| 8/27 | Austin Mack | WR | off IR undisclosed |
| 8/24 | Sam Schlueter | T | on IR undisclosed |
| 8/23 | Jason Verrett | CB | Placed on PUPL |
| 8/23 | Jeremiah Gemmel | LB | cut |
| 8/23 | Tanner Hudson | TE | cut |
| 8/23 | Kalia Davis | DT | reserve/non football injury knee |
| 8/23 | Austin Mack | WR | on IR undisclosed |
| 8/22 | Tashaun Gipson Sr. | S | signed/unrest FA One-year contract (through 2022) |
| 8/16 | Robert Nkemdiche | DT | cut |
| 8/15 | Darqueze Dennard | CB | cut |
| 8/15 | Josh Hokit | TE | cut |
| 8/15 | KeeSean Johnson | WR | cut |
| 8/15 | Tomasi Laulile | DT | cut |
| 8/12 | Leon O'Neal Jr. | S | cut |
| 8/12 | Leon O'Neal Jr. | S | off IR undisclosed |
| 8/11 | Leon O'Neal Jr. | S | on IR undisclosed |
| 8/10 | Ken Crawley | CB | signed/unrest FA One-year contract (through 2022) |
| 8/6 | Jordan Mills | T | signed/unrest FA One-year contract (through 2022) |
| 8/6 | Willie Snead IV | WR | signed One-year contract (through 2022) |
| 8/5 | Taysir Mack | WR | cut |
| 8/4 | Jordan Matthews | TE | on IR torn left ACL |
| 8/1 | Akeem Spence | DT | signed One-year contract (through 2022) |
| 8/1 | Maurice Hurst | DT | on IR torn biceps |
| 7/31 | Deebo Samuel | WR | re-signed Three-year extension (through 2025) |
| 7/29 | Tomasi Laulile | DT | signed |
| 7/27 | Dee Ford | DE | cut |
| 7/26 | Robert Nkemdiche | DT | signed/unrest FA One-year contract (through 2022) |
| 6/2 | Frank Gore | RB | signed One-day contract |
| 6/2 | Frank Gore | RB | retired |
| 6/2 | Alex Mack | C | retired |
| 6/2 | Spencer Burford | G | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Tariq Castro-Fields | CB | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Kalia Davis | DT | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Tyrion Davis-Price | RB | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Danny Gray | WR | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Drake Jackson | DE | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Brock Purdy | QB | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Samuel Womack III | CB | signed/draft choice Four-year contract (through 2025) |
| 6/2 | Nick Zakelj | G | signed/draft choice Four-year contract (through 2025) |
| 5/23 | Tyler Kroft | TE | signed/unrest FA One-year contract (through 2022) |
| 5/23 | Chris Slayton | DT | cut |
| 5/17 | Troy Fumagalli | TE | signed/unrest FA One-year contract (through 2022) |
| 5/17 | Garrett Walston | TE | cut |
| 5/13 | Kevin Atkins | DT | signed |
| 5/13 | Jeremiah Gemmel | LB | signed |
| 5/13 | Tayler Hawkins | S | signed |
| 5/13 | Qwuantrezz Knight | CB | signed |
| 5/13 | Taysir Mack | WR | signed |
| 5/13 | Tay Martin | WR | signed |
| 5/13 | Jordan Mason | RB | signed |
| 5/13 | Marcelino McCrary-Ball | LB | signed |
| 5/13 | Segun Olubi | LB | signed |
| 5/13 | Leon O'Neal Jr. | S | signed |
| 5/13 | Jason Poe | G | signed |
| 5/13 | Sam Schlueter | T | signed |
| 5/13 | Garrett Walston | TE | signed |
| 5/13 | Dohnovan West | C | signed |
| 5/13 | Connor Wedington | WR | cut |
| 5/2 | Jason Verrett | CB | re-signed/unrest FA One-year contract (through 2022) |
| 4/25 | Nick Bosa | DE | team exercises option Fifth-year option on rookie contract |
| 4/25 | Azeez Al-Shaair | LB | re-signed/rest FA One-year contract (through 2022) |
| 4/19 | Daniel Brunskill | T | re-signed/rest FA One-year contract (through 2022) |
| 4/19 | Jauan Jennings | WR | re-signed/excl. FA One-year contract (through 2022) |
| 4/14 | Kemoko Turay | DE | signed/unrest FA One-year contract (through 2022) |
| 4/11 | Marcus Johnson | WR | signed/unrest FA One-year contract (through 2022) |
| 4/11 | Malik Turner | WR | signed/unrest FA One-year contract (through 2022) |
| 4/11 | Maurice Hurst | DT | cut |
| 4/11 | Maurice Hurst | DT | signed One-year contract (through 2022) |
| 3/29 | Jeff Wilson Jr. | RB | re-signed/unrest FA One-year contract (through 2022) |
| 3/28 | Ross Dwelley | TE | re-signed/unrest FA One-year contract (through 2022) |
| 3/25 | Darqueze Dennard | CB | signed One-year contract (through 2022) |
| 3/24 | Kerry Hyder Jr. | DE | signed One-year contract (through 2022) |
| 3/24 | Dontae Johnson | CB | re-signed/unrest FA One-year contract (through 2022) |
| 3/23 | Jordan Willis | DE | re-signed/unrest FA One-year contract (through 2022) |
| 3/22 | George Odum | S | signed/unrest FA Three-year contract (through 2024) |
| 3/22 | Ray-Ray McCloud III | WR | signed/unrest FA One-year contract (through 2022) |
| 3/21 | Hassan Ridgeway | DT | signed/unrest FA One-year contract (through 2022) |
| 3/17 | Oren Burks | LB | signed/unrest FA Two-year contract (through 2023) |
| 3/16 | Charvarius Ward | CB | signed/unrest FA Three-year contract (through 2024) |
| 3/16 | Trenton Cannon | RB | Declared Free Agent |
| 3/16 | Laken Tomlinson | G | Declared Free Agent |
| 3/16 | Travis Benjamin | WR | Declared Free Agent |
| 3/16 | Tom Compton | G | Declared Free Agent |
| 3/16 | Ross Dwelley | TE | Declared Free Agent |
| 3/16 | Marcell Harris | LB | Declared Free Agent |
| 3/16 | Richie James Jr. | WR | Declared Free Agent |
| 3/16 | Dontae Johnson | CB | Declared Free Agent |
| 3/16 | D.J. Jones | DT | Declared Free Agent |
| 3/16 | Arden Key | LB | Declared Free Agent |
| 3/16 | Raheem Mostert | RB | Declared Free Agent |
| 3/16 | Josh Norman | CB | Declared Free Agent |
| 3/16 | Mohamed Sanu Sr. | WR | Declared Free Agent |
| 3/16 | Trent Sherfield | WR | Declared Free Agent |
| 3/16 | Jaquiski Tartt | S | Declared Free Agent |
| 3/16 | Jason Verrett | CB | Declared Free Agent |
| 3/16 | K'Waun Williams | CB | Declared Free Agent |
| 3/16 | Jordan Willis | DE | Declared Free Agent |
| 3/16 | Tavon Wilson | S | Declared Free Agent |
| 3/16 | Jeff Wilson Jr. | RB | Declared Free Agent |
| 3/16 | Azeez Al-Shaair | LB | Restricted Free Agent |
| 3/16 | Daniel Brunskill | T | Restricted Free Agent |
| 3/16 | Kentavius Street | DT | Declared Free Agent |
| 3/11 | Demetrius Flannigan-Fowles | LB | re-signed/excl. FA One-year extension (through 2022) |
| 3/10 | Kevin Givens | DT | re-signed One-year extension (through 2022) |
| 3/10 | JaMycal Hasty | RB | re-signed One-year extension (through 2022) |
| 3/10 | Maurice Hurst | DT | re-signed One-year extension (through 2022) |
| 3/10 | Colton McKivitz | T | re-signed One-year extension (through 2022) |
| 3/10 | Nate Sudfeld | QB | signed |
| 3/9 | Jake Brendel | C | re-signed One-year extension (through 2022) |
| 3/8 | Keaton Sutherland | G | signed |
| 2/15 | Tarvarius Moore | S | Activated from PUPL |
Last updated Oct. 5, 1:09 A.M. ET
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