Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 11 | Brandon Aiyuk | WR | 3 | 6-0 | 200 | 3/17/1998 | Reno, NV | Arizona State |
| 51 | Azeez Al-Shaair | LB | 4 | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 91 | Arik Armstead | DT | 8 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| Kevin Atkins | DT | R | 6-2 | 307 | 7/30/1998 | San Diego, CA | Fresno State | |
| 65 | Aaron Banks | G | 2 | 6-5 | 325 | 9/3/1997 | Alameda, CA | Notre Dame |
| 58 | Alex Barrett | DE | 2 | 6-2 | 250 | 3/6/1994 | Yuma, AZ | San Diego State |
| 97 | Nick Bosa | DE | 4 | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 64 | Jake Brendel | C | 4 | 6-4 | 299 | 9/10/1992 | Madison, WI | UCLA |
| 60 | Daniel Brunskill | T | 4 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 74 | Spencer Burford | G | R | 6-4 | 300 | 7/19/2000 | Texas-San Antonio | |
| Oren Burks | LB | 5 | 6-3 | 233 | 3/21/1995 | Vanderbilt | ||
| 36 | Tariq Castro-Fields | CB | R | 6-1 | 197 | 1/14/1999 | Upper Marlboro, MD | Penn State |
| 93 | Kalia Davis | DT | R | 6-2 | 310 | 10/2/1998 | Pensacola, FL | UCF |
| 32 | Tyrion Davis-Price | RB | R | 6-1 | 219 | 10/23/2000 | Baton Rouge, LA | LSU |
| 43 | Darqueze Dennard | CB | 9 | 5-11 | 202 | 10/10/1991 | Dry Branch, GA | Michigan State |
| 82 | Ross Dwelley | TE | 5 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| 56 | Samson Ebukam | LB | 6 | 6-3 | 245 | 5/9/1995 | Nigeria | Eastern Washington |
| 45 | Demetrius Flannigan-Fowles | LB | 3 | 6-2 | 210 | 9/4/1996 | Arizona | |
| 55 | Dee Ford | DE | 9 | 6-2 | 252 | 3/19/1991 | Odenville, AL | Auburn |
| 10 | Jimmy Garoppolo | QB | 9 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| Jeremiah Gemmel | LB | R | 6-1 | 225 | 11/5/1998 | Newnan, GA | North Carolina | |
| 90 | Kevin Givens | DT | 3 | 6-1 | 285 | 3/1/1997 | Penn State | |
| 9 | Robbie Gould | K | 18 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 86 | Danny Gray | WR | R | 6-0 | 200 | 4/1/1999 | Ruston, LA | Southern Methodist |
| 57 | Dre Greenlaw | LB | 4 | 6-0 | 227 | 5/25/1997 | Arkansas | |
| 77 | Alfredo Gutierrez | G | 1 | 6-7 | 332 | 12/29/1995 | Tijuana, Mexico | Monterrey Tech |
| 23 | JaMycal Hasty | RB | 3 | 5-8 | 205 | 9/12/1996 | Baylor | |
| Tayler Hawkins | S | R | 6-1 | 205 | 12/27/1997 | Palm Springs, CA | San Diego State | |
| 40 | Josh Hokit | RB | 1 | 6-1 | 225 | 11/12/1997 | Fresno State | |
| Ka'dar Hollman | CB | 3 | 6-0 | 196 | 9/18/1994 | Toledo | ||
| 84 | Tanner Hudson | TE | 4 | 6-5 | 239 | 11/12/1994 | Southern Arkansas | |
| 29 | Talanoa Hufanga | S | 2 | 6-0 | 200 | 2/2/1999 | Corvallis, OR | USC |
| 96 | Maurice Hurst | DT | 5 | 6-2 | 291 | 5/9/1995 | Michigan | |
| 92 | Kerry Hyder Jr. | DE | 7 | 6-2 | 275 | 5/2/1991 | Austin, TX | Texas Tech |
| 95 | Drake Jackson | DE | R | 6-4 | 273 | 4/12/2001 | USC | |
| 15 | Jauan Jennings | WR | 2 | 6-3 | 212 | 7/10/1997 | Cowan, TN | Tennessee |
| 27 | Dontae Johnson | CB | 9 | 6-2 | 200 | 12/1/1991 | Pennington, NJ | North Carolina State |
| KeeSean Johnson | WR | 3 | 6-1 | 201 | 10/9/1996 | Mountain View, CA | Fresno State | |
| Marcus Johnson | WR | 6 | 6-1 | 207 | 8/5/1994 | League City, TX | Texas | |
| 44 | Kyle Juszczyk | RB | 10 | 6-1 | 235 | 4/23/1991 | Medina, OH | Harvard |
| 99 | Javon Kinlaw | DT | 3 | 6-5 | 319 | 10/3/1997 | Washington, DC | South Carolina |
| 85 | George Kittle | TE | 6 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| Qwuantrezz Knight | S | R | 6-0 | 199 | 10/10/1997 | Gretna, FL | UCLA | |
| 5 | Trey Lance | QB | 2 | 6-4 | 224 | 5/9/2000 | Marshall, MN | North Dakota State |
| 38 | Deommodore Lenoir | CB | 2 | 5-10 | 200 | 10/6/1999 | Los Angeles, CA | Oregon |
| 50 | Alex Mack | C | 14 | 6-4 | 311 | 11/19/1985 | Santa Barbara, CA | California |
| 86 | Austin Mack | WR | 2 | 6-2 | 215 | 8/31/1997 | Ohio State | |
| Taysir Mack | WR | R | 6-2 | 190 | 9/17/1998 | Brooklyn, NY | Pittsburgh | |
| Tay Martin | WR | R | 6-3 | 185 | 12/14/1997 | Houma, LA | Oklahoma State | |
| Jordan Mason | RB | R | 6-1 | 223 | 5/24/1999 | Gallatin, TN | Georgia Tech | |
| 88 | Jordan Matthews | TE | 9 | 6-3 | 236 | 7/16/1992 | Madison, AL | Vanderbilt |
| Ray-Ray McCloud III | WR | 5 | 5-9 | 190 | 10/15/1996 | Clemson | ||
| Marcelino McCrary-Ball | LB | R | 6-0 | 214 | 3/23/1999 | Roswell, GA | Indiana | |
| 69 | Mike McGlinchey | T | 5 | 6-8 | 310 | 1/12/1995 | Notre Dame | |
| 68 | Colton McKivitz | T | 3 | 6-6 | 301 | 8/9/1996 | Jacobsburg, OH | West Virginia |
| 25 | Eli Mitchell | RB | 2 | 5-10 | 200 | 5/2/1998 | Louisiana | |
| 76 | Jaylon Moore | T | 2 | 6-4 | 311 | 1/9/1998 | Western Michigan | |
| 33 | Tarvarius Moore | S | 4 | 6-2 | 200 | 8/16/1996 | Southern Miss | |
| 4 | Emmanuel Moseley | CB | 5 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| Leon O'Neal Jr. | S | R | 6-1 | 210 | 12/23/1998 | Cypress, TX | Texas A&M | |
| George Odum | S | 5 | 6-1 | 202 | 11/3/1993 | Central Arkansas | ||
| Segun Olubi | LB | R | 6-2 | 220 | 11/1/1999 | Philadelphia, PA | San Diego State | |
| 92 | Charles Omenihu | DE | 4 | 6-5 | 280 | 8/20/1997 | Houston, TX | Texas |
| 46 | Taybor Pepper | C | 5 | 6-4 | 245 | 5/28/1994 | Michigan State | |
| Jason Poe | G | R | 6-1 | 300 | 7/27/1998 | Fitzgerald, GA | Mercer | |
| 14 | Brock Purdy | QB | R | 6-1 | 220 | 12/27/1999 | Queen Creek, AZ | Iowa State |
| Hassan Ridgeway | DT | 7 | 6-3 | 305 | 11/2/1994 | Rodeo, CA | Texas | |
| 59 | Curtis Robinson | LB | 2 | 6-3 | 235 | 6/2/1998 | Stanford | |
| 19 | Deebo Samuel | WR | 4 | 6-0 | 215 | 1/15/1996 | South Carolina | |
| Sam Schlueter | T | R | 6-6 | 309 | 8/11/1997 | Victoria, MN | Minnesota | |
| 28 | Trey Sermon | RB | 2 | 6-0 | 215 | 1/30/1999 | Marietta, GA | Ohio State |
| 67 | Justin Skule | T | 3 | 6-6 | 315 | 11/23/1996 | Vanderbilt | |
| 78 | Chris Slayton | DT | 2 | 6-4 | 316 | 8/1/1996 | Syracuse | |
| 7 | Nate Sudfeld | QB | 7 | 6-6 | 227 | 10/7/1993 | Modesto, CA | Indiana |
| Keaton Sutherland | G | 4 | 6-5 | 315 | 2/12/1997 | Texas A&M | ||
| 20 | Ambry Thomas | CB | 2 | 6-0 | 190 | 9/9/1999 | Detroit, MI | Michigan |
| Kemoko Turay | DE | 5 | 6-5 | 248 | 7/11/1995 | Rutgers | ||
| Malik Turner | WR | 4 | 6-2 | 202 | 1/30/1996 | Illinois | ||
| 2 | Jason Verrett | CB | 9 | 5-10 | 188 | 6/18/1991 | Fairfield, CA | TCU |
| Garrett Walston | TE | R | 6-4 | 245 | 1/20/1998 | Wilmington, NC | North Carolina | |
| Charvarius Ward | CB | 5 | 6-1 | 196 | 5/16/1996 | Middle Tennessee State | ||
| 1 | Jimmie Ward | S | 9 | 5-11 | 195 | 7/18/1991 | Racine, WI | Northern Illinois |
| 54 | Fred Warner | LB | 5 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| Dohnovan West | G | R | 6-4 | 300 | 5/19/2001 | Mission Hills, CA | Arizona State | |
| 71 | Trent Williams | T | 12 | 6-5 | 320 | 7/19/1988 | Longview, TX | Oklahoma |
| 94 | Jordan Willis | DE | 6 | 6-4 | 270 | 5/2/1995 | San Diego, CA | Kansas State |
| 22 | Jeff Wilson Jr. | RB | 5 | 6-0 | 213 | 11/16/1995 | Elkhart, TX | North Texas |
| 18 | Mitch Wishnowsky | P | 4 | 6-2 | 220 | 3/3/1992 | Utah | |
| 89 | Charlie Woerner | TE | 3 | 6-5 | 241 | 10/16/1997 | Tiger, GA | Georgia |
| 26 | Samuel Womack III | CB | R | 5-10 | 189 | 7/7/1999 | Toledo | |
| 63 | Nick Zakelj | G | R | 6-6 | 316 | 6/22/1999 | Fordham |
Head Coach: Kyle Shanahan
Last updated May 16, 6:18 p.m. ET
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