Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 11 | Brandon Aiyuk | WR | R | 6-1 | 206 | 3/17/1998 | Reno, NV | Arizona State |
| Adonis Alexander | CB | 2 | 6-3 | 205 | 11/7/1996 | Virginia Tech | ||
| 51 | Azeez Al-Shaair | LB | 2 | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 98 | Ezekiel Ansah | DE | 8 | 6-5 | 275 | 5/29/1989 | Accra, Ghana | Brigham Young |
| 91 | Arik Armstead | DT | 6 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| 64 | Alex Barrett | DE | 1 | 6-2 | 250 | 3/6/1994 | Yuma, AZ | San Diego State |
| 3 | C.J. Beathard | QB | 4 | 6-2 | 215 | 11/16/1993 | Franklin, TN | Iowa |
| 17 | Travis Benjamin | WR | 9 | 5-10 | 175 | 12/29/1989 | Belle Glade, FL | Miami (FL) |
| 62 | Tony Bergstrom | G | 9 | 6-5 | 310 | 8/6/1986 | Salt Lake City, UT | Utah |
| 98 | Ronald Blair III | DT | 5 | 6-4 | 270 | 1/21/1993 | Greensboro, NC | Appalachian State |
| 97 | Nick Bosa | DE | 2 | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 84 | Kendrick Bourne | WR | 4 | 6-1 | 190 | 8/4/1995 | Portland, OR | Eastern Washington |
| 64 | Jake Brendel | C | 4 | 6-4 | 299 | 9/10/1992 | Madison, WI | UCLA |
| 60 | Daniel Brunskill | T | 2 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 77 | Josiah Coatney | DT | R | 6-4 | 325 | 1/4/1996 | Mississippi | |
| 17 | Matt Cole | WR | R | 5-10 | 197 | 11/7/1996 | McKendree | |
| 78 | Shon Coleman | T | 4 | 6-5 | 310 | 11/25/1991 | Memphis, TN | Auburn |
| 26 | Tevin Coleman | RB | 6 | 6-1 | 210 | 4/16/1993 | Tinley Park, IL | Indiana |
| 66 | Tom Compton | G | 8 | 6-6 | 315 | 5/10/1989 | Rosemount, MN | South Dakota |
| 86 | River Cracraft | WR | 3 | 6-0 | 198 | 11/1/1994 | Washington State | |
| 65 | Darrion Daniels | DT | R | 6-4 | 325 | 12/4/1997 | Nebraska | |
| 82 | Ross Dwelley | TE | 3 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| 38 | Chris Edwards | S | 1 | 6-2 | 215 | 12/23/1992 | Dallas, TX | Idaho |
| 45 | Demetrius Flannigan-Fowles | LB | 1 | 6-2 | 210 | 9/4/1996 | Arizona | |
| 55 | Dee Ford | DE | 7 | 6-2 | 252 | 3/19/1991 | Odenville, AL | Auburn |
| 63 | Ben Garland | G | 7 | 6-5 | 304 | 4/6/1988 | Grand Junction, CO | Air Force |
| 10 | Jimmy Garoppolo | QB | 7 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| 90 | Kevin Givens | DT | 1 | 6-1 | 285 | 3/1/1997 | Penn State | |
| 9 | Robbie Gould | K | 16 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 50 | Hroniss Grasu | C | 5 | 6-3 | 301 | 8/12/1991 | Northridge, CA | Oregon |
| 57 | Dre Greenlaw | LB | 2 | 6-0 | 227 | 5/25/1997 | Arkansas | |
| 5 | Jonas Griffith | LB | R | 6-4 | 250 | Indiana State | ||
| 77 | Daeshon Hall | DE | 4 | 6-5 | 265 | 6/14/1995 | Lancaster, TX | Texas A&M |
| 83 | Chase Harrell | TE | R | 6-4 | 249 | 5/16/1997 | Arkansas | |
| 36 | Marcell Harris | S | 3 | 6-0 | 208 | 6/9/1994 | Florida | |
| 35 | Tim Harris Jr. | CB | 1 | 6-1 | 205 | 7/31/1995 | Virginia | |
| 38 | JaMycal Hasty | RB | R | 5-9 | 205 | 9/12/1996 | Baylor | |
| 40 | Josh Hokit | RB | R | 6-1 | 225 | 11/12/1997 | Fresno State | |
| 14 | Jalen Hurd | WR | 1 | 6-4 | 230 | 1/23/1996 | Baylor | |
| 92 | Kerry Hyder | DE | 5 | 6-2 | 275 | 5/2/1991 | Austin, TX | Texas Tech |
| 13 | Richie James | WR | 3 | 5-9 | 185 | 9/5/1995 | Middle Tennessee State | |
| 17 | Jauan Jennings | WR | R | 6-3 | 212 | 7/10/1997 | Cowan, TN | Tennessee |
| 27 | Dontae Johnson | CB | 7 | 6-2 | 200 | 12/1/1991 | Pennington, NJ | North Carolina State |
| 1 | Josh Johnson | QB | 8 | 6-3 | 205 | 5/15/1986 | Oakland, CA | San Diego |
| 93 | D.J. Jones | DT | 4 | 6-0 | 305 | 1/19/1995 | Greenville, SC | Mississippi |
| 96 | Dion Jordan | DE | 6 | 6-6 | 275 | 3/5/1990 | Chandler, AZ | Oregon |
| 44 | Kyle Juszczyk | RB | 8 | 6-1 | 235 | 4/23/1991 | Medina, OH | Harvard |
| Corbin Kaufusi | DE | 1 | 6-9 | 275 | 4/12/1993 | Brigham Young | ||
| 99 | Javon Kinlaw | DT | R | 6-6 | 310 | 10/3/1997 | Washington, DC | South Carolina |
| 85 | George Kittle | TE | 4 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| James Lockhart | LB | R | 6-2 | 263 | 9/12/1996 | Baylor | ||
| 43 | Jared Mayden | S | R | 6-0 | 205 | 6/24/1998 | Alabama | |
| 69 | Mike McGlinchey | T | 3 | 6-8 | 310 | 1/12/1995 | Notre Dame | |
| 28 | Jerick McKinnon | RB | 7 | 5-9 | 205 | 5/3/1992 | Atlanta, GA | Georgia Southern |
| 68 | Colton McKivitz | T | R | 6-6 | 301 | 8/9/1996 | Jacobsburg, OH | West Virginia |
| Obi Melifonwu | S | 4 | 6-4 | 224 | 4/5/1994 | South Grafton, MA | Connecticut | |
| 33 | Tarvarius Moore | S | 3 | 6-2 | 200 | 8/16/1996 | Southern Miss | |
| 41 | Emmanuel Moseley | CB | 3 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| 31 | Raheem Mostert | RB | 6 | 5-10 | 205 | 4/9/1992 | Smyrna Beach, FL | Purdue |
| 4 | Nick Mullens | QB | 3 | 6-1 | 210 | 3/21/1995 | Hoover, AL | Southern Miss |
| 43 | Kai Nacua | S | 2 | 6-0 | 205 | 3/3/1995 | Brigham Young | |
| 53 | Mark Nzeocha | LB | 6 | 6-3 | 235 | 1/19/1990 | Neusitz, West Germany | Wyoming |
| 46 | Taybor Pepper | C | 3 | 6-4 | 245 | 5/28/1994 | Michigan State | |
| Austin Proehl | WR | 1 | 5-10 | 175 | 10/11/1995 | North Carolina | ||
| 81 | Jordan Reed | TE | 8 | 6-2 | 242 | 7/3/1990 | New London, CT | Florida |
| 2 | Josh Rosen | QB | 3 | 6-4 | 226 | 2/10/1997 | UCLA | |
| 19 | Deebo Samuel | WR | 2 | 6-0 | 215 | 1/15/1996 | South Carolina | |
| 61 | Dakoda Shepley | G | 1 | 6-5 | 290 | 12/27/1994 | Windsor, Canada | University of British Columbia |
| 25 | Richard Sherman | CB | 10 | 6-3 | 205 | 3/30/1988 | Compton, CA | Stanford |
| 67 | Justin Skule | T | 2 | 6-6 | 315 | 11/23/1996 | Vanderbilt | |
| 95 | Kentavius Street | DE | 2 | 6-2 | 287 | 5/8/1996 | North Carolina State | |
| 29 | Jaquiski Tartt | S | 6 | 6-1 | 215 | 2/18/1992 | Mobile, AL | Samford |
| 47 | Jamar Taylor | CB | 8 | 5-11 | 192 | 9/29/1990 | San Diego, CA | Boise State |
| 15 | Trent Taylor | WR | 4 | 5-8 | 180 | 4/30/1994 | Cookeville, TN | Louisiana Tech |
| 94 | Solomon Thomas | DE | 4 | 6-3 | 280 | 8/26/1995 | Chicago, IL | Stanford |
| 2 | Chris Thompson | WR | 2 | 6-0 | 175 | 5/9/1994 | Florida | |
| 75 | Laken Tomlinson | G | 6 | 6-3 | 315 | 2/9/1992 | Jamaica | Duke |
| 22 | Jason Verrett | CB | 7 | 5-10 | 188 | 6/18/1991 | Fairfield, CA | TCU |
| 59 | Joe Walker | LB | 5 | 6-2 | 236 | 12/11/1992 | Oregon | |
| 48 | Austin Walter | RB | 1 | 5-8 | 202 | 8/17/1996 | Houston, TX | Rice |
| 20 | Jimmie Ward | S | 7 | 5-11 | 195 | 7/18/1991 | Racine, WI | Northern Illinois |
| 54 | Fred Warner | LB | 3 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| 40 | Ken Webster | CB | 2 | 5-11 | 191 | 6/19/1996 | Mississippi | |
| 14 | Kevin White | WR | 5 | 6-3 | 216 | 6/25/1992 | Plainfield, NJ | West Virginia |
| 76 | Isaiah Williams | T | 1 | 6-3 | 306 | 5/5/1993 | Akron | |
| 24 | K'Waun Williams | CB | 6 | 5-9 | 185 | 7/12/1991 | Paterson, NJ | Pittsburgh |
| 71 | Trent Williams | T | 10 | 6-5 | 320 | 7/19/1988 | Longview, TX | Oklahoma |
| 78 | Jordan Willis | DE | 4 | 6-4 | 270 | 5/2/1995 | San Diego, CA | Kansas State |
| 30 | Jeff Wilson Jr. | RB | 3 | 6-0 | 194 | 11/16/1995 | Elkhart, TX | North Texas |
| 6 | Mitch Wishnowsky | P | 2 | 6-2 | 220 | 3/3/1992 | Utah | |
| 23 | Ahkello Witherspoon | CB | 4 | 6-3 | 195 | 3/21/1995 | Oak Park, CA | Colorado |
| 89 | Charlie Woerner | TE | R | 6-5 | 241 | 10/16/1997 | Tiger, GA | Georgia |
Head Coach: Kyle Shanahan
Last updated Feb. 16, 1:28 a.m. ET
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