Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 11 | Brandon Aiyuk | WR | R | 6-1 | 206 | 3/17/1998 | Reno, NV | Arizona State |
| 56 | Kwon Alexander | LB | 6 | 6-1 | 227 | 8/3/1994 | Oxford, AL | LSU |
| 51 | Azeez Al-Shaair | LB | 2 | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 91 | Arik Armstead | DT | 6 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| 3 | C.J. Beathard | QB | 4 | 6-2 | 215 | 11/16/1993 | Franklin, TN | Iowa |
| 97 | Nick Bosa | DE | 2 | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 84 | Kendrick Bourne | WR | 4 | 6-1 | 190 | 8/4/1995 | Portland, OR | Eastern Washington |
| 60 | Daniel Brunskill | T | 2 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 26 | Tevin Coleman | RB | 6 | 6-1 | 210 | 4/16/1993 | Tinley Park, IL | Indiana |
| 66 | Tom Compton | G | 8 | 6-6 | 315 | 5/10/1989 | Rosemount, MN | South Dakota |
| 82 | Ross Dwelley | TE | 3 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| 45 | Demetrius Flannigan-Fowles | LB | 1 | 6-2 | 210 | 9/4/1996 | Arizona | |
| 55 | Dee Ford | DE | 7 | 6-2 | 252 | 3/19/1991 | Odenville, AL | Auburn |
| 63 | Ben Garland | G | 7 | 6-5 | 304 | 4/6/1988 | Grand Junction, CO | Air Force |
| 10 | Jimmy Garoppolo | QB | 7 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| 90 | Kevin Givens | DT | 1 | 6-1 | 285 | 3/1/1997 | Penn State | |
| 9 | Robbie Gould | K | 16 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 57 | Dre Greenlaw | LB | 2 | 6-0 | 227 | 5/25/1997 | Arkansas | |
| 36 | Marcell Harris | S | 3 | 6-0 | 208 | 6/9/1994 | Florida | |
| 92 | Kerry Hyder | DE | 5 | 6-2 | 275 | 5/2/1991 | Austin, TX | Texas Tech |
| 27 | Dontae Johnson | CB | 7 | 6-2 | 200 | 12/1/1991 | Pennington, NJ | North Carolina State |
| 93 | D.J. Jones | DT | 4 | 6-0 | 305 | 1/19/1995 | Greenville, SC | Mississippi |
| 44 | Kyle Juszczyk | RB | 8 | 6-1 | 235 | 4/23/1991 | Medina, OH | Harvard |
| 99 | Javon Kinlaw | DT | R | 6-6 | 310 | 10/3/1997 | Washington, DC | South Carolina |
| 85 | George Kittle | TE | 4 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| 69 | Mike McGlinchey | T | 3 | 6-8 | 310 | 1/12/1995 | Notre Dame | |
| 28 | Jerick McKinnon | RB | 7 | 5-9 | 205 | 5/3/1992 | Atlanta, GA | Georgia Southern |
| 68 | Colton McKivitz | T | R | 6-6 | 301 | 8/9/1996 | Jacobsburg, OH | West Virginia |
| 33 | Tarvarius Moore | S | 3 | 6-2 | 200 | 8/16/1996 | Southern Miss | |
| 41 | Emmanuel Moseley | CB | 3 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| 31 | Raheem Mostert | RB | 6 | 5-10 | 205 | 4/9/1992 | Smyrna Beach, FL | Purdue |
| 4 | Nick Mullens | QB | 3 | 6-1 | 210 | 3/21/1995 | Hoover, AL | Southern Miss |
| 86 | Kyle Nelson | TE | 9 | 6-2 | 240 | 10/3/1986 | Waco, TX | New Mexico State |
| 53 | Mark Nzeocha | LB | 6 | 6-3 | 235 | 1/19/1990 | Neusitz, West Germany | Wyoming |
| 18 | Dante Pettis | WR | 3 | 6-1 | 195 | 10/23/1995 | Washington | |
| 81 | Jordan Reed | TE | 8 | 6-2 | 242 | 7/3/1990 | New London, CT | Florida |
| 14 | Mohamed Sanu | WR | 9 | 6-2 | 210 | 8/22/1989 | South Brunswick, NJ | Rutgers |
| 67 | Justin Skule | T | 2 | 6-6 | 315 | 11/23/1996 | Vanderbilt | |
| 95 | Kentavius Street | DE | 2 | 6-2 | 287 | 5/8/1996 | North Carolina State | |
| 29 | Jaquiski Tartt | S | 6 | 6-1 | 215 | 2/18/1992 | Mobile, AL | Samford |
| 15 | Trent Taylor | WR | 4 | 5-8 | 180 | 4/30/1994 | Cookeville, TN | Louisiana Tech |
| 94 | Solomon Thomas | DE | 4 | 6-3 | 280 | 8/26/1995 | Chicago, IL | Stanford |
| 75 | Laken Tomlinson | G | 6 | 6-3 | 315 | 2/9/1992 | Jamaica | Duke |
| 22 | Jason Verrett | CB | 7 | 5-10 | 188 | 6/18/1991 | Fairfield, CA | TCU |
| 20 | Jimmie Ward | S | 7 | 5-11 | 195 | 7/18/1991 | Racine, WI | Northern Illinois |
| 54 | Fred Warner | LB | 3 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| 35 | Ken Webster | CB | 2 | 5-11 | 191 | 6/19/1996 | Mississippi | |
| 24 | K'Waun Williams | CB | 6 | 5-9 | 185 | 7/12/1991 | Paterson, NJ | Pittsburgh |
| 71 | Trent Williams | T | 10 | 6-5 | 320 | 7/19/1988 | Longview, TX | Oklahoma |
| 30 | Jeff Wilson Jr. | RB | 3 | 6-0 | 194 | 11/16/1995 | Elkhart, TX | North Texas |
| 6 | Mitch Wishnowsky | P | 2 | 6-2 | 220 | 3/3/1992 | Utah | |
| 23 | Ahkello Witherspoon | CB | 4 | 6-3 | 195 | 3/21/1995 | Oak Park, CA | Colorado |
| 89 | Charlie Woerner | TE | R | 6-5 | 241 | 10/16/1997 | Tiger, GA | Georgia |
Head Coach: Kyle Shanahan
Last updated Sep. 19, 1:08 a.m. ET
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