Injuries
| Date | Player | Status |
| 1/29 | E. Mitchell | groin (Questionable) |
| 1/29 | A. Thomas | ankle (Questionable) |
| 1/22 | A. Thomas | ankle (Out) |
| 1/14 | A. Thomas | ankle (Out) |
| 1/8 | J. Feliciano | back (Questionable) |
| 1/8 | A. Banks | ankle, knee (Out) |
| 1/8 | K. Givens | knee (Out) |
| 1/8 | D. Greenlaw | back (Out) |
| 1/8 | J. Kinlaw | knee (Questionable) |
| 1/8 | A. Armstead | foot, ankle (Questionable) |
| 1/8 | A. Thomas | ankle (Out) |
| 1/1 | K. Givens | knee (Out) |
| 1/1 | D. Samuel | ankle, knee (Out) |
| 1/1 | K. Hyder Jr. | ankle (Questionable) |
| 1/1 | A. Thomas | ankle, illness (Questionable) |
| 12/24 | K. Givens | knee (Out) |
| 12/24 | D. Samuel | ankle, knee (Out) |
| 12/24 | K. Hyder Jr. | ankle (Questionable) |
| 12/24 | J. Mason | hamstring (Questionable) |
| 12/24 | A. Thomas | ankle (Questionable) |
| 12/24 | C. Ward | concussion (Questionable) |
| 12/15 | K. Givens | knee (Out) |
| 12/15 | D. Samuel | ankle, knee (Out) |
| 12/15 | S. Womack III | concussion (Out) |
| 12/15 | K. Hyder Jr. | ankle (Questionable) |
| 12/15 | B. Purdy | oblique, rib (Questionable) |
| 12/15 | A. Thomas | ankle (Questionable) |
| 12/11 | N. Bosa | hamstring (Questionable) |
| 12/11 | M. Hartsfield | ankle (Questionable) |
| 12/4 | D. Samuel | quadriceps (Questionable) |
| 12/4 | S. Burford | ankle (Questionable) |
| 12/4 | T. Williams | back (Questionable) |
| 12/4 | J. Feliciano | neck (Questionable) |
| 12/3 | E. Mitchell | knee (Injured-Reserve (DFR)) |
| 11/27 | M. Hartsfield | ankle (Out) |
| 11/27 | A. Armstead | foot, ankle (Doubtful) |
| 11/27 | D. Samuel | hamstring (Questionable) |
| 11/24 | J. Feliciano | neck (Out) |
| 11/21 | A. Armstead | foot, ankle (Out) |
| 11/20 | M. Hartsfield | ankle (Doubtful) |
| 11/13 | A. Armstead | foot, ankle (Out) |
| 11/12 | J. Verrett | torn Achilles tendon (IR) |
| 11/6 | A. Parker | hip (Out) |
| 10/30 | A. Armstead | foot, ankle (Out) |
| 10/30 | D. Greenlaw | calf (Out) |
| 10/30 | J. Jennings | hamstring (Questionable) |
| 10/30 | K. Juszczyk | finger (Out) |
| 10/30 | D. Samuel | hamstring (Out) |
| 10/30 | J. Verrett | knee (Questionable) |
| 10/23 | J. Feliciano | groin (Questionable) |
| 10/23 | A. Armstead | foot (Questionable) |
| 10/23 | T. Davis-Price | ankle (Out) |
| 10/23 | T. Kroft | knee (Out) |
| 10/16 | A. Armstead | ankle, foot (Out) |
| 10/16 | T. Williams | ankle (Out) |
| 10/16 | A. Banks | knee (Questionable) |
| 10/16 | N. Bosa | groin (Questionable) |
| 10/16 | T. Kroft | knee (Questionable) |
| 10/15 | J. Kinlaw | knee (Injured-Reserve (DFR)) |
| 10/8 | C. McKivitz | sprained MCL (Injured-Reserve (DFR)) |
| 10/3 | A. Armstead | foot (Questionable) |
| 10/3 | T. Davis-Price | ankle (Out) |
| 10/3 | R. Dwelley | rib (Questionable) |
| 10/3 | D. Gray | hip (Doubtful) |
| 10/3 | J. Kinlaw | knee (Questionable) |
| 10/3 | T. Kroft | knee (Out) |
| 10/3 | T. Williams | ankle (Out) |
| 10/2 | C. McCaffrey | thigh (Questionable) |
| 9/25 | A. Armstead | foot (Questionable) |
| 9/25 | T. Davis-Price | ankle (Out) |
| 9/25 | T. Kroft | knee (Out) |
| 9/25 | C. McKivitz | ankle (Questionable) |
| 9/21 | T. Lance | broken right ankle (IR) |
| 9/18 | G. Kittle | groin (Questionable) |
| 9/13 | E. Mitchell | sprained right MCL (Injured-Reserve (DFR)) |
| 9/11 | G. Kittle | groin (Questionable) |
| 9/1 | I. Oliver | undisclosed (Injured-Reserve (DFR)) |
| 8/31 | T. Sharpe | rib (IR) |
| 8/31 | S. Darnold | left ankle sprain (Injured-Reserve (DFR)) |
| 8/31 | C. Robinson | high ankle sprain (Injured-Reserve (DFR)) |
| 8/30 | K. Ismael | undisclosed (IR) |
| 8/29 | T. McGill | ankle (IR) |
| 8/23 | A. Mack | undisclosed (IR) |
| 8/11 | L. O'Neal Jr. | undisclosed (IR) |
| 8/4 | J. Matthews | torn left ACL (IR) |
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