Transactions
| Date | Player | Pos | Transactions |
| 5/17 | Daniel Joseph | DE | signed |
| 5/16 | Will Ulmer | T | signed |
| 5/16 | Ja'Marcus Ingram | CB | signed |
| 5/16 | Prince Emili | DT | signed |
| 5/16 | C.J. Brewer | DT | signed |
| 5/14 | Travon Fuller | CB | signed |
| 5/13 | Alec Anderson | T | signed |
| 5/13 | Kaiir Elam | CB | signed/draft choice Four-year contract (fifth-year option) |
| 5/13 | James Cook | RB | signed/draft choice Four-year contract (through 2025) |
| 5/13 | Khalil Shakir | WR | signed/draft choice Four-year contract (through 2025) |
| 5/13 | Matt Araiza | P | signed/draft choice Four-year contract (through 2025) |
| 5/13 | Christian Benford | CB | signed/draft choice Four-year contract (through 2025) |
| 5/13 | Luke Tenuta | T | signed/draft choice Four-year contract (through 2025) |
| 5/13 | Raheem Blackshear | RB | signed |
| 5/13 | Kingsley Jonathan | DE | signed |
| 5/13 | Derek Kerstetter | T | signed |
| 5/13 | Tanner Owen | T | signed |
| 5/13 | Malik Williams | WR | signed |
| 5/13 | Jalen Wydermyer | TE | signed |
| 5/13 | Neil Pau'u | WR | signed |
| 5/12 | Terrel Bernard | LB | signed/draft choice Four-year contract (through 2025) |
| 5/12 | Baylon Spector | LB | signed/draft choice Four-year contract (through 2025) |
| 4/26 | Ed Oliver | DT | team exercises option Fifth-year option on rookie contract |
| 4/21 | David Quessenberry | G | signed/unrest FA One-year contract (through 2022) |
| 4/11 | Bobby Hart | T | re-signed/unrest FA One-year contract (through 2022) |
| 4/6 | Stefon Diggs | WR | re-signed Four-year extension (through 2027) |
| 4/4 | Taiwan Jones | RB | re-signed/unrest FA One-year contract (through 2022) |
| 4/1 | Christian Wade | RB | cut |
| 3/29 | Ryan Bates | T | Matched Offer Sheet Four-year contract (through 2025) |
| 3/28 | Ike Boettger | G | re-signed/unrest FA One-year contract (through 2022) |
| 3/22 | Jamison Crowder | WR | signed/unrest FA One-year contract (through 2022) |
| 3/21 | Matt Barkley | QB | signed One-year contract (through 2022) |
| 3/21 | Duke Johnson | RB | signed/unrest FA One-year contract (through 2022) |
| 3/21 | Greg Mancz | C | signed/unrest FA One-year contract (through 2022) |
| 3/20 | Case Keenum | QB | traded for 2022 seventh-round draft pick |
| 3/18 | Star Lotulelei | DT | cut |
| 3/18 | Marquel Lee | LB | signed/unrest FA One-year contract (through 2022) |
| 3/18 | Shaq Lawson | DE | signed One-year contract (through 2022) |
| 3/17 | Tim Settle | DT | signed/unrest FA Two-year contract (through 2023) |
| 3/17 | Cole Beasley | WR | cut |
| 3/17 | Von Miller | LB | signed/unrest FA Six-year contract (through 2027) |
| 3/17 | O.J. Howard | TE | signed/unrest FA One-year contract (through 2022) |
| 3/17 | Jordan Phillips | DT | signed One-year contract (through 2022) |
| 3/16 | Harrison Phillips | DT | Declared Free Agent |
| 3/16 | Mitch Trubisky | QB | Declared Free Agent |
| 3/16 | Mario Addison | DE | Declared Free Agent |
| 3/16 | Ike Boettger | G | Declared Free Agent |
| 3/16 | Matt Breida | RB | Declared Free Agent |
| 3/16 | Vernon Butler | DT | Declared Free Agent |
| 3/16 | Bryan Cox Jr. | DE | Declared Free Agent |
| 3/16 | Bobby Hart | T | Declared Free Agent |
| 3/16 | Jerry Hughes | DE | Declared Free Agent |
| 3/16 | Taiwan Jones | RB | Declared Free Agent |
| 3/16 | Efe Obada | DE | Declared Free Agent |
| 3/16 | Emmanuel Sanders | WR | Declared Free Agent |
| 3/16 | Levi Wallace | CB | Declared Free Agent |
| 3/16 | Ryan Bates | T | Restricted Free Agent |
| 3/16 | Justin Zimmer | DT | Declared Free Agent |
| 3/16 | DaQuan Jones | DT | signed/unrest FA Two-year contract (through 2023) |
| 3/14 | Daryl Williams | G | cut |
| 3/14 | Mitch Morse | C | re-signed Two-year extension (through 2024) |
| 3/14 | Rodger Saffold | G | signed One-year contract (through 2022) |
| 3/13 | Isaiah McKenzie | WR | re-signed Two-year contract (through 2023) |
| 3/10 | Jake Kumerow | WR | re-signed One-year extension (through 2022) |
| 3/10 | Jon Feliciano | G | cut |
| 3/8 | A.J. Klein | LB | cut |
| 2/23 | Siran Neal | CB | re-signed Three-year extension (through 2024) |
Last updated May 25, 1:18 A.M. ET
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