Transactions
| Date | Player | Pos | Transactions |
| 10/14 | Davontae Harris | CB | pract. squad add |
| 10/12 | Davontae Harris | CB | cut |
| 10/12 | Jacques Patrick | RB | cut |
| 10/11 | Tanner Hudson | TE | pract. squad add |
| 10/11 | Nate Sudfeld | QB | pract. squad add |
| 10/11 | Buster Skrine | CB | cut |
| 10/9 | Travis Benjamin | WR | active/prac. squad |
| 10/9 | Tanner Hudson | TE | active/prac. squad |
| 10/9 | Nate Sudfeld | QB | active/prac. squad |
| 10/9 | George Kittle | TE | on IR calf |
| 10/5 | Jordan Matthews | TE | pract. squad add |
| 10/5 | Curtis Bolton | LB | pract. squad del |
| 10/5 | Kerryon Johnson | RB | pract. squad del |
| 10/5 | Chris Thompson | RB | pract. squad del |
| 10/5 | Joey Slye | K | signed One-year contract (through 2021) |
| 10/5 | Tyrell Adams | LB | pract. squad add |
| 10/5 | Connor Wedington | WR | pract. squad add |
| 10/5 | Robbie Gould | K | on IR groin |
| 9/29 | Buster Skrine | CB | signed One-year contract (through 2021) |
| 9/27 | Kerryon Johnson | RB | pract. squad add |
| 9/25 | Kerryon Johnson | RB | active/prac. squad |
| 9/25 | Kevin Givens | DT | on IR ankle |
| 9/25 | JaMycal Hasty | RB | on IR high-ankle sprain |
| 9/22 | Chris Thompson | RB | pract. squad add |
| 9/22 | Eddie Yarbrough | DE | pract. squad add |
| 9/22 | Jordan Matthews | TE | pract. squad del |
| 9/21 | Jacques Patrick | RB | active/prac. squad |
| 9/21 | Dee Virgin | CB | pract. squad del |
| 9/18 | Dre Greenlaw | LB | on IR groin |
| 9/15 | Trenton Cannon | RB | acquired from waiver |
| 9/14 | Dontae Johnson | CB | active/prac. squad |
| 9/14 | Dre Kirkpatrick | CB | signed/unrest FA |
| 9/14 | Curtis Bolton | LB | pract. squad add |
| 9/14 | Kerryon Johnson | RB | pract. squad add |
| 9/14 | Isaiah Zuber | WR | pract. squad del |
| 9/14 | Jason Verrett | CB | on IR torn ACL |
| 9/13 | Dontae Johnson | CB | pract. squad add |
| 9/13 | Raheem Mostert | RB | on IR chipped knee cartilage |
| 9/11 | Dontae Johnson | CB | active/prac. squad |
| 9/11 | Jalen Hurd | WR | on IR knee |
| 9/10 | Rashad Smith | LB | pract. squad del |
| 9/10 | Kai Nacua | S | pract. squad add |
| 9/10 | Shon Coleman | T | cut |
| 9/10 | Shon Coleman | T | off IR undisclosed |
| 9/8 | Nate Gerry | LB | pract. squad add |
| 9/8 | Corbin Kaufusi | DE | pract. squad del |
| 9/7 | Dontae Johnson | CB | pract. squad add |
| 9/7 | Elijah Sullivan | LB | pract. squad del |
| 9/6 | Josh Norman | CB | signed/unrest FA One-year contract (through 2021) |
| 9/6 | Dontae Johnson | CB | cut |
| 9/3 | Rashad Smith | LB | pract. squad add |
| 9/3 | Dee Virgin | CB | pract. squad add |
| 9/3 | Isaiah Zuber | WR | pract. squad add |
| 9/2 | Mychal Kendricks | LB | cut |
| 9/2 | Tanner Hudson | TE | pract. squad add |
| 9/2 | Mychal Kendricks | LB | off IR turf toe |
| 9/1 | Jake Brendel | C | signed |
| 9/1 | Dontae Johnson | CB | signed |
| 9/1 | Alex Barrett | DE | pract. squad add |
| 9/1 | Travis Benjamin | WR | pract. squad add |
| 9/1 | River Cracraft | WR | pract. squad add |
| 9/1 | Darrion Daniels | DT | pract. squad add |
| 9/1 | Alfredo Gutierrez | G | Exempt/Commissioner's Permission List International Player Pathway Program |
| 9/1 | Josh Hokit | RB | pract. squad add |
| 9/1 | Corbin Kaufusi | DE | pract. squad add |
| 9/1 | Senio Kelemete | G | pract. squad add |
| 9/1 | Jordan Matthews | TE | pract. squad add |
| 9/1 | Jared Mayden | S | pract. squad add |
| 9/1 | Colton McKivitz | T | pract. squad add |
| 9/1 | Nate Sudfeld | QB | pract. squad add |
| 9/1 | Elijah Sullivan | LB | pract. squad add |
| 9/1 | Richie James | WR | on IR knee |
| 8/31 | Senio Kelemete | G | cut |
| 8/31 | MyCole Pruitt | TE | cut |
| 8/31 | Jake Brendel | C | cut |
| 8/31 | Ha Ha Clinton-Dix | S | cut |
| 8/31 | Tarvarius Moore | S | Placed on PUPL |
| 8/31 | Jeff Wilson Jr. | RB | Placed on PUPL |
| 8/31 | Travis Benjamin | WR | cut |
| 8/31 | Wayne Gallman Jr. | RB | cut |
| 8/31 | Dontae Johnson | CB | cut |
| 8/31 | Jordan Matthews | TE | cut |
| 8/31 | Nate Sudfeld | QB | cut |
| 8/31 | Eddie Yarbrough | DE | cut |
| 8/31 | Alex Barrett | DE | cut |
| 8/31 | River Cracraft | WR | cut |
| 8/31 | Darrion Daniels | DT | cut |
| 8/31 | Justin Hilliard | LB | cut |
| 8/31 | Josh Hokit | RB | cut |
| 8/31 | Corbin Kaufusi | DE | cut |
| 8/31 | Jared Mayden | S | cut |
| 8/31 | Colton McKivitz | T | cut |
| 8/31 | Alex Myres | CB | cut |
| 8/31 | Dakoda Shepley | C | cut |
| 8/31 | Elijah Sullivan | LB | cut |
| 8/31 | Nsimba Webster | WR | cut |
| 8/31 | Shon Coleman | T | on IR undisclosed |
| 8/28 | River Cracraft | WR | signed One-year contract (through 2021) |
| 8/27 | Corbin Kaufusi | DE | signed |
| 8/27 | Kai Nacua | S | cut |
| 8/25 | Austin Watkins Jr. | WR | cut |
| 8/25 | Austin Watkins Jr. | WR | off IR broken foot |
| 8/24 | Shilique Calhoun | DE | cut |
| 8/24 | B.W. Webb | CB | cut |
| 8/24 | River Cracraft | WR | cut |
| 8/24 | Corbin Kaufusi | DE | cut |
| 8/24 | Mychal Kendricks | LB | on IR turf toe |
| 8/23 | Tony Jefferson II | S | cut |
| 8/23 | Tony Jefferson II | S | off IR groin, hamstring |
| 8/18 | Austin Watkins Jr. | WR | on IR broken foot |
| 8/17 | Joshua Perkins | TE | cut |
| 8/17 | Ken Webster | CB | cut |
| 8/17 | Davontae Harris | CB | acquired from waiver |
| 8/17 | Josh Rosen | QB | cut |
| 8/16 | Mychal Kendricks | LB | signed/unrest FA One-year contract (through 2021) |
| 8/16 | James Burgess Jr. | LB | cut |
| 8/16 | Donald Payne | LB | cut |
| 8/16 | Eddie Vanderdoes | DT | cut |
| 8/12 | Ha Ha Clinton-Dix | S | signed One-year contract (through 2021) |
| 8/12 | Eddie Vanderdoes | DT | signed One-year contract (through 2021) |
| 8/12 | Davin Bellamy | LB | cut |
| 8/12 | Tony Jefferson II | S | on IR groin, hamstring |
| 8/11 | Donald Payne | LB | signed One-year contract (through 2021) |
| 8/11 | Kevin White | WR | cut |
| 8/11 | Tim Harris Jr. | CB | cut |
| 8/11 | Tim Harris Jr. | CB | off IR groin |
| 8/10 | Shilique Calhoun | DE | signed/unrest FA One-year contract (through 2021) |
| 8/10 | Alex Myres | CB | signed One-year contract (through 2021) |
| 8/10 | Mark Fields II | CB | cut |
| 8/10 | Isaiah Williams | T | cut |
| 8/6 | Anthony Zettel | DE | retired |
| 8/6 | Davin Bellamy | LB | signed |
| 8/6 | Jauan Jennings | WR | reinstated |
| 8/6 | Emmanuel Moseley | CB | reinstated |
| 8/6 | Jaquiski Tartt | S | reinstated |
| 8/5 | Tim Harris Jr. | CB | on IR groin |
| 8/4 | B.W. Webb | CB | signed One-year contract (through 2021) |
| 8/4 | Joshua Perkins | TE | signed/unrest FA One-year contract (through 2021) |
| 8/4 | Josh Pederson | TE | cut |
| 7/31 | Bennie Fowler III | WR | cut |
| 7/31 | Jordan Matthews | TE | signed One-year contract (through 2021) |
| 7/28 | Trey Lance | QB | signed/draft choice Four-year contract (fifth-year option) |
| 7/28 | Jauan Jennings | WR | reserve/non football injury COVID-19 |
| 7/28 | Jaquiski Tartt | S | reserve/non football injury COVID-19 |
| 7/27 | Andy Jones | WR | cut |
| 7/27 | Anthony Zettel | DE | signed |
| 7/27 | Emmanuel Moseley | CB | reserve/non football injury COVID-19 |
| 7/27 | Eddie Yarbrough | DE | signed |
| 7/26 | Ambry Thomas | CB | signed/draft choice Four-year contract (through 2024) |
| 7/25 | Daeshon Hall | DE | cut |
| 7/22 | Fred Warner | LB | re-signed Five-year extension (through 2026) |
| 7/21 | Trey Sermon | RB | signed/draft choice Four-year contract (through 2024) |
| 7/21 | Nsimba Webster | WR | acquired from waiver |
| 7/6 | Nate Gerry | LB | cut |
| 6/17 | Jordan Willis | DE | suspended 6 games (NFL Policy on PEDs) |
| 6/14 | Justin Skule | T | on IR torn ACL |
| 6/11 | Senio Kelemete | G | signed One-year contract (through 2021) |
| 6/7 | Tony Jefferson II | S | signed One-year contract (through 2021) |
| 6/7 | Briean Boddy-Calhoun | S | cut |
| 6/2 | James Burgess Jr. | LB | signed/unrest FA One-year contract (through 2021) |
| 6/2 | Weston Richburg | C | retired |
| 6/2 | MyCole Pruitt | TE | signed/unrest FA One-year contract (through 2021) |
| 6/1 | Josh Johnson | QB | cut |
| 6/1 | Andy Jones | WR | signed One-year contract (through 2021) |
| 6/1 | Daniel Helm | TE | cut |
| 5/21 | Bennie Fowler III | WR | signed/unrest FA One-year contract (through 2021) |
| 5/21 | Marqise Lee | WR | cut |
| 5/17 | Marqise Lee | WR | signed One-year contract (through 2021) |
| 5/17 | Austin Proehl | WR | cut |
| 5/13 | Alfredo Gutierrez | G | signed International Player Pathway Program |
| 5/13 | Aaron Banks | G | signed/draft choice Four-year contract (through 2024) |
| 5/13 | Jaylon Moore | T | signed/draft choice Four-year contract (through 2024) |
| 5/13 | Deommodore Lenoir | CB | signed/draft choice Four-year contract (through 2024) |
| 5/13 | Talanoa Hufanga | S | signed/draft choice Four-year contract (through 2024) |
| 5/13 | Eli Mitchell | RB | signed/draft choice Four-year contract (through 2024) |
| 5/13 | Justin Hilliard | LB | signed |
| 5/13 | Josh Pederson | TE | signed |
| 5/13 | Elijah Sullivan | LB | signed |
| 5/13 | Austin Watkins Jr. | WR | signed |
| 5/12 | Austin Walter | RB | cut |
| 5/4 | Adonis Alexander | CB | cut |
| 5/4 | Matt Cole | WR | cut |
| 5/4 | Chris Edwards | S | cut |
| 4/29 | Obi Melifonwu | S | cut |
| 4/28 | Tom Compton | G | re-signed/unrest FA One-year contract (through 2021) |
| 4/27 | Josiah Coatney | DT | cut |
| 4/26 | Mike McGlinchey | T | team exercises option Fifth-year option on rookie contract |
| 4/23 | Arden Key | DE | signed One-year contract (through 2021) |
| 4/23 | Maurice Hurst | DT | signed One-year contract (through 2021) |
| 4/21 | Wayne Gallman Jr. | RB | signed/unrest FA One-year contract (through 2021) |
| 4/20 | Jordan Reed | TE | retired |
| 4/14 | Daniel Brunskill | T | re-signed/excl. FA One-year contract (through 2021) |
| 4/14 | Chase Harrell | TE | cut |
| 4/7 | Nate Sudfeld | QB | signed/unrest FA One-year contract (through 2021) |
| 4/1 | Jason Verrett | CB | re-signed/unrest FA One-year contract (through 2021) |
| 3/30 | Mohamed Sanu | WR | signed/unrest FA One-year contract (through 2021) |
| 3/29 | Nate Gerry | LB | signed/unrest FA One-year contract (through 2021) |
| 3/24 | Jordan Willis | DE | re-signed/unrest FA One-year contract (through 2021) |
| 3/24 | K'Waun Williams | CB | re-signed/unrest FA One-year contract (through 2021) |
| 3/23 | Zach Kerr | DT | signed One-year contract (through 2021) |
| 3/23 | Trent Williams | T | re-signed/unrest FA Six-year contract (through 2026) |
| 3/22 | D.J. Jones | DT | re-signed/unrest FA One-year contract (through 2021) |
| 3/22 | Tavon Wilson | S | signed/unrest FA One-year contract (through 2021) |
| 3/22 | Jaquiski Tartt | S | re-signed/unrest FA One-year contract (through 2021) |
| 3/20 | Chris Thompson | WR | cut |
| 3/19 | Samson Ebukam | LB | signed/unrest FA Two-year contract (through 2022) |
| 3/19 | Trent Sherfield | WR | signed/unrest FA One-year contract (through 2021) |
| 3/19 | Dontae Johnson | CB | re-signed/unrest FA One-year contract (through 2021) |
| 3/18 | Alex Mack | C | signed/unrest FA Three-year contract (through 2023) |
| 3/17 | Jason Verrett | CB | Declared Free Agent |
| 3/17 | Trent Williams | T | Declared Free Agent |
| 3/17 | Marquise Goodwin | WR | cut |
| 3/17 | Ezekiel Ansah | DE | Declared Free Agent |
| 3/17 | C.J. Beathard | QB | Declared Free Agent |
| 3/17 | Tony Bergstrom | G | Declared Free Agent |
| 3/17 | Kendrick Bourne | WR | Declared Free Agent |
| 3/17 | Tevin Coleman | RB | Declared Free Agent |
| 3/17 | Tom Compton | G | Declared Free Agent |
| 3/17 | Ben Garland | G | Declared Free Agent |
| 3/17 | Hroniss Grasu | C | Declared Free Agent |
| 3/17 | Kerry Hyder Jr. | DE | Declared Free Agent |
| 3/17 | Dontae Johnson | CB | Declared Free Agent |
| 3/17 | D.J. Jones | DT | Declared Free Agent |
| 3/17 | Dion Jordan | DE | Declared Free Agent |
| 3/17 | Jerick McKinnon | RB | Declared Free Agent |
| 3/17 | Mark Nzeocha | LB | Declared Free Agent |
| 3/17 | Jordan Reed | TE | Declared Free Agent |
| 3/17 | Richard Sherman | CB | Declared Free Agent |
| 3/17 | Jaquiski Tartt | S | Declared Free Agent |
| 3/17 | Jamar Taylor | CB | Declared Free Agent |
| 3/17 | Trent Taylor | WR | Declared Free Agent |
| 3/17 | Solomon Thomas | DT | Declared Free Agent |
| 3/17 | Joe Walker | LB | Declared Free Agent |
| 3/17 | K'Waun Williams | CB | Declared Free Agent |
| 3/17 | Jordan Willis | DE | Declared Free Agent |
| 3/17 | Ahkello Witherspoon | CB | Declared Free Agent |
| 3/17 | Nick Mullens | QB | Declared Free Agent |
| 3/17 | Briean Boddy-Calhoun | S | signed One-year contract (through 2021) |
| 3/17 | Daniel Helm | TE | signed One-year contract (through 2021) |
| 3/16 | Marquise Goodwin | WR | traded Reveresion of previous trade |
| 3/14 | Kyle Juszczyk | RB | re-signed Five-year extension (through 2025) |
| 3/12 | Emmanuel Moseley | CB | re-signed Two-year extension (through 2022) |
| 3/12 | Ronald Blair III | DT | cut |
| 3/5 | Ross Dwelley | TE | re-signed/excl. FA One-year contract (through 2021) |
| 3/5 | Marcell Harris | S | re-signed/excl. FA One-year contract (through 2021) |
| 3/3 | Mark Fields II | CB | acquired from waiver |
| 2/22 | River Cracraft | WR | re-signed One-year extension (through 2021) |
Last updated Oct. 16, 12:59 P.M. ET
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