Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 11 | Brandon Aiyuk | WR | 2 | 6-0 | 200 | 3/17/1998 | Reno, NV | Arizona State |
| 51 | Azeez Al-Shaair | LB | 3 | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 91 | Arik Armstead | DT | 7 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| 65 | Aaron Banks | G | R | 6-5 | 325 | 9/3/1997 | Alameda, CA | Notre Dame |
| 17 | Travis Benjamin | WR | 9 | 5-10 | 175 | 12/29/1989 | Belle Glade, FL | Miami (FL) |
| 97 | Nick Bosa | DE | 3 | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 64 | Jake Brendel | C | 3 | 6-4 | 299 | 9/10/1992 | Madison, WI | UCLA |
| 60 | Daniel Brunskill | T | 3 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 66 | Tom Compton | G | 9 | 6-6 | 315 | 5/10/1989 | Rosemount, MN | South Dakota |
| 13 | River Cracraft | WR | 4 | 6-0 | 198 | 11/1/1994 | Washington State | |
| 82 | Ross Dwelley | TE | 4 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| 56 | Samson Ebukam | LB | 5 | 6-3 | 245 | 5/9/1995 | Nigeria | Eastern Washington |
| 45 | Demetrius Flannigan-Fowles | LB | 2 | 6-2 | 210 | 9/4/1996 | Arizona | |
| 10 | Jimmy Garoppolo | QB | 8 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| 90 | Kevin Givens | DT | 2 | 6-1 | 285 | 3/1/1997 | Penn State | |
| 9 | Robbie Gould | K | 17 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 57 | Dre Greenlaw | LB | 3 | 6-0 | 227 | 5/25/1997 | Arkansas | |
| 36 | Marcell Harris | S | 4 | 6-0 | 208 | 6/9/1994 | Florida | |
| 23 | JaMycal Hasty | RB | 2 | 5-8 | 205 | 9/12/1996 | Baylor | |
| 29 | Talanoa Hufanga | S | R | 6-0 | 200 | 2/2/1999 | Corvallis, OR | USC |
| 96 | Maurice Hurst | DT | 4 | 6-2 | 291 | 5/9/1995 | Michigan | |
| 15 | Jauan Jennings | WR | 1 | 6-3 | 212 | 7/10/1997 | Cowan, TN | Tennessee |
| 27 | Dontae Johnson | CB | 8 | 6-2 | 200 | 12/1/1991 | Pennington, NJ | North Carolina State |
| 93 | D.J. Jones | DT | 5 | 6-0 | 305 | 1/19/1995 | Greenville, SC | Mississippi |
| 44 | Kyle Juszczyk | RB | 9 | 6-1 | 235 | 4/23/1991 | Medina, OH | Harvard |
| 98 | Arden Key | DE | 4 | 6-5 | 240 | 5/3/1996 | LSU | |
| 85 | George Kittle | TE | 5 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| 5 | Trey Lance | QB | R | 6-4 | 224 | 5/9/2000 | Marshall, MN | North Dakota State |
| 38 | Deommodore Lenoir | CB | R | 5-10 | 200 | 10/6/1999 | Los Angeles, CA | Oregon |
| 50 | Alex Mack | C | 13 | 6-4 | 311 | 11/19/1985 | Santa Barbara, CA | California |
| 68 | Colton McKivitz | T | 2 | 6-6 | 301 | 8/9/1996 | Jacobsburg, OH | West Virginia |
| 25 | Eli Mitchell | RB | R | 5-10 | 200 | 5/2/1998 | Louisiana | |
| 76 | Jaylon Moore | T | R | 6-4 | 311 | 1/9/1998 | Western Michigan | |
| 4 | Emmanuel Moseley | CB | 4 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| 26 | Josh Norman | CB | 10 | 6-0 | 200 | 12/15/1987 | Greenwood, SC | Coastal Carolina |
| 92 | Charles Omenihu | DE | 3 | 6-5 | 280 | 8/20/1997 | Houston, TX | Texas |
| 46 | Taybor Pepper | C | 4 | 6-4 | 245 | 5/28/1994 | Michigan State | |
| 19 | Deebo Samuel | WR | 3 | 6-0 | 215 | 1/15/1996 | South Carolina | |
| 28 | Trey Sermon | RB | R | 6-0 | 215 | 1/30/1999 | Marietta, GA | Ohio State |
| 81 | Trent Sherfield | WR | 4 | 6-1 | 219 | 2/26/1996 | Vanderbilt | |
| 95 | Kentavius Street | DE | 3 | 6-2 | 287 | 5/8/1996 | North Carolina State | |
| 3 | Jaquiski Tartt | S | 7 | 6-1 | 215 | 2/18/1992 | Mobile, AL | Samford |
| 20 | Ambry Thomas | CB | R | 6-0 | 190 | 9/9/1999 | Detroit, MI | Michigan |
| 75 | Laken Tomlinson | G | 7 | 6-3 | 315 | 2/9/1992 | Jamaica | Duke |
| 1 | Jimmie Ward | S | 8 | 5-11 | 195 | 7/18/1991 | Racine, WI | Northern Illinois |
| 54 | Fred Warner | LB | 4 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| 24 | K'Waun Williams | CB | 7 | 5-9 | 185 | 7/12/1991 | Paterson, NJ | Pittsburgh |
| 71 | Trent Williams | T | 11 | 6-5 | 320 | 7/19/1988 | Longview, TX | Oklahoma |
| 94 | Jordan Willis | DE | 5 | 6-4 | 270 | 5/2/1995 | San Diego, CA | Kansas State |
| 22 | Jeff Wilson Jr. | RB | 4 | 6-0 | 213 | 11/16/1995 | Elkhart, TX | North Texas |
| 18 | Mitch Wishnowsky | P | 3 | 6-2 | 220 | 3/3/1992 | Utah | |
| 89 | Charlie Woerner | TE | 2 | 6-5 | 241 | 10/16/1997 | Tiger, GA | Georgia |
Head Coach: Kyle Shanahan
Last updated Jan. 25, 4:09 p.m. ET
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