Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Justin Skule | ||
| Left Guard | Laken Tomlinson | ||
| Center | Daniel Brunskill | Hroniss Grasu | |
| Right Guard | Tony Bergstrom | Colton McKivitz | |
| Right Tackle | Mike McGlinchey | ||
| Wide Receiver | Brandon Aiyuk | Kendrick Bourne | Trent Taylor |
| Wide Receiver | Deebo Samuel | Richie James | River Cracraft |
| Running Back | Jeff Wilson Jr. | Jerick McKinnon | Tevin Coleman |
| Tight End | George Kittle | Jordan Reed | Ross Dwelley |
| Quarterback | C.J. Beathard | Josh Rosen | |
| Defense | |||
| Position | |||
| Left Defensive End | Kerry Hyder | Alex Barrett | |
| Left Defensive Tackle | Javon Kinlaw | Kevin Givens | Darrion Daniels |
| Right Defensive Tackle | D.J. Jones | Kentavius Street | |
| Right Defensive End | Arik Armstead | Dion Jordan | |
| Strong Linebacker | Dre Greenlaw | Mark Nzeocha | |
| Middle Linebacker | Fred Warner | Azeez Al-Shaair | |
| Weak Linebacker | Demetrius Flannigan-Fowles | Joe Walker | |
| Left Cornerback | Richard Sherman | Emmanuel Moseley | K'Waun Williams |
| Right Cornerback | Jason Verrett | Ahkello Witherspoon | |
| Strong Safety | Marcell Harris | Dontae Johnson | |
| Free Safety | Jimmie Ward | Tarvarius Moore | Kai Nacua |
| Special Teams | |||
| Position | |||
| Kicker | Robbie Gould | ||
| Kick-Offs | Robbie Gould | ||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Jerick McKinnon | Trent Taylor | |
| Punt Returner | Trent Taylor | ||
| Holder | Mitch Wishnowsky | ||
© 2021 by STATS PERFORM.Any commercial use or distribution without the express written consent of STATS PERFORM is strictly prohibited.