Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Trent Williams | Justin Skule | Colton McKivitz |
| Left Guard | Laken Tomlinson | Kofi Amichia | |
| Center | Weston Richburg | Ben Garland | Jake Brendel |
| Right Guard | Tom Compton | Ross Reynolds | |
| Right Tackle | Mike McGlinchey | Daniel Brunskill | Jaryd Jones-Smith |
| Wide Receiver | Deebo Samuel | Kendrick Bourne | Dante Pettis |
| Wide Receiver | Brandon Aiyuk | Jalen Hurd | Trent Taylor |
| Running Back | Raheem Mostert | Tevin Coleman | Jerick McKinnon |
| Tight End | George Kittle | Ross Dwelley | Daniel Helm |
| Quarterback | Jimmy Garoppolo | Nick Mullens | C.J. Beathard |
| Defense | |||
| Position | |||
| Left Defensive End | Arik Armstead | Dee Ford | Ronald Blair III |
| Left Defensive Tackle | Solomon Thomas | Jullian Taylor | Darrion Daniels |
| Right Defensive Tackle | Javon Kinlaw | D.J. Jones | Kevin Givens |
| Right Defensive End | Nick Bosa | Kentavius Street | Kerry Hyder |
| Strong Linebacker | Dre Greenlaw | ||
| Middle Linebacker | Fred Warner | Joe Walker | Azeez Al-Shaair |
| Weak Linebacker | Kwon Alexander | Mark Nzeocha | Jonas Griffith |
| Left Cornerback | Richard Sherman | K'Waun Williams | Jason Verrett |
| Right Cornerback | Ahkello Witherspoon | Dontae Johnson | Jamar Taylor |
| Strong Safety | Jaquiski Tartt | Marcell Harris | Demetrius Flannigan-Fowles |
| Free Safety | Jimmie Ward | Tarvarius Moore | Jared Mayden |
| Special Teams | |||
| Position | |||
| Kicker | Robbie Gould | ||
| Kick-Offs | Robbie Gould | ||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Dante Pettis | Richie James Jr. | |
| Punt Returner | Dante Pettis | Richie James Jr. | |
| Holder | Mitch Wishnowsky | ||
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