Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Trent Williams | Colton McKivitz | Leroy Watson |
| Left Guard | Aaron Banks | Jason Poe | |
| Center | Jake Brendel | Keith Ismael | |
| Right Guard | Spencer Burford | Nick Zakelj | Alfredo Gutierrez |
| Right Tackle | Jaylon Moore | ||
| Wide Receiver | Brandon Aiyuk | Danny Gray | Jauan Jennings |
| Wide Receiver | Deebo Samuel | Ray-Ray McCloud III | Tyron Johnson |
| Running Back | Christian McCaffrey | Elijah Mitchell | Jordan Mason |
| Tight End | George Kittle | Charlie Woerner | Ross Dwelley |
| Quarterback | Brock Purdy | Trey Lance | Sam Darnold |
| Defense | |||
| Position | |||
| Left Defensive End | Clelin Ferrell | Alex Barrett | Austin Bryant |
| Left Defensive Tackle | Javon Kinlaw | Kevin Givens | T.Y. McGill |
| Right Defensive Tackle | Javon Hargrave | Arik Armstead | Kalia Davis |
| Right Defensive End | Nick Bosa | Drake Jackson | |
| Strong Linebacker | Oren Burks | ||
| Middle Linebacker | Fred Warner | Curtis Robinson | Marcelino McCrary-Ball |
| Weak Linebacker | Dre Greenlaw | Demetrius Flannigan-Fowles | |
| Left Cornerback | Deommodore Lenoir | Isaiah Oliver | Tre Swilling |
| Right Cornerback | Charvarius Ward | Samuel Womack III | Qwuantrezz Knight |
| Strong Safety | Talanoa Hufanga | Myles Hartsfield | AJ Parker |
| Free Safety | Tashaun Gipson Sr. | George Odum | Tayler Hawkins |
| Special Teams | |||
| Position | |||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Ray-Ray McCloud III | Danny Gray | |
| Punt Returner | Ray-Ray McCloud III | Brandon Aiyuk | |
| Holder | Mitch Wishnowsky | ||
© 2023 by STATS PERFORM.Any commercial use or distribution without the express written consent of STATS PERFORM is strictly prohibited.