Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Trent Williams | Colton McKivitz | |
| Left Guard | Aaron Banks | Blake Hance | |
| Center | Jake Brendel | Daniel Brunskill | |
| Right Guard | Spencer Burford | Nick Zakelj | |
| Right Tackle | Mike McGlinchey | Jaylon Moore | |
| Wide Receiver | Deebo Samuel | Jauan Jennings | Ray-Ray McCloud III |
| Wide Receiver | Brandon Aiyuk | Danny Gray | |
| Running Back | Jeff Wilson Jr. | Marlon Mack | Tyrion Davis-Price |
| Tight End | George Kittle | Ross Dwelley | Charlie Woerner |
| Quarterback | Jimmy Garoppolo | Brock Purdy | |
| Defense | |||
| Position | |||
| Left Defensive End | Samson Ebukam | Kemoko Turay | |
| Left Defensive Tackle | Javon Kinlaw | Kevin Givens | |
| Right Defensive Tackle | Arik Armstead | Hassan Ridgeway | |
| Right Defensive End | Nick Bosa | Drake Jackson | Kerry Hyder Jr. |
| Strong Linebacker | Azeez Al-Shaair | ||
| Middle Linebacker | Fred Warner | Oren Burks | |
| Weak Linebacker | Dre Greenlaw | Demetrius Flannigan-Fowles | |
| Left Cornerback | Ambry Thomas | Emmanuel Moseley | |
| Right Cornerback | Charvarius Ward | Samuel Womack III | |
| Strong Safety | Talanoa Hufanga | George Odum | Tashaun Gipson Sr. |
| Free Safety | Tarvarius Moore | Deommodore Lenoir | |
| Special Teams | |||
| Position | |||
| Kicker | Robbie Gould | ||
| Kick-Offs | Robbie Gould | ||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Ray-Ray McCloud III | Ambry Thomas | |
| Punt Returner | Ray-Ray McCloud III | Brandon Aiyuk | |
| Holder | Mitch Wishnowsky | ||
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