| First Quarter |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 63 yards from Pit30 to SD7, Darren Sproles returns to SD25 for 18 yards | | |
| SD | 1st&10 | SD25 | Philip Rivers Pass to Antonio Gates to SD46 for 21 yards | | |
| SD | 1st&10 | SD46 | Darren Sproles Off Left Guard to SD47 for 1 yard | | |
| SD | 2nd&9 | SD47 | Philip Rivers Pass to Darren Sproles to Pit41 for 12 yards | | |
| SD | 1st&10 | Pit41 | Philip Rivers Pass to Vincent Jackson for 41 yards for a TOUCHDOWN | | |
| SD | | | SD-Vincent Jackson PENALIZED -15 yards for Unsports. Conduct | | |
| SD | | | Nate Kaeding extra point is GOOD. Holder-Mike Scifres | | |
| SD | | | Drive Stats: 4 plays, 75 yards, 2min 1sec | 7 | 0 |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Mike Scifres kicks 55 yards from SD15 to Pit30, Carey Davis returns to Pit42 for 12 yards | | |
| Pit | 1st&10 | Pit42 | Willie Parker up the Middle to SD46 for 12 yards | | |
| Pit | 1st&10 | SD46 | Willie Parker up the Middle to SD44 for 2 yards | | |
| Pit | 2nd&8 | SD44 | Willie Parker up the Middle to SD36 for 8 yards | | |
| Pit | 1st&10 | SD36 | Ben Roethlisberger Pass to Hines Ward to SD35 for 1 yard | | |
| Pit | | | Pit-Santonio Holmes PENALIZED -10 yards for Holding | | |
| Pit | 1st&19 | SD45 | Ben Roethlisberger Pass Incomplete to Hines Ward | | |
| Pit | 2nd&19 | SD45 | Ben Roethlisberger Pass to Heath Miller to SD34 for 11 yards | | |
| Pit | 3rd&8 | SD34 | Ben Roethlisberger Pass Incomplete to Santonio Holmes | | |
| Pit | 4th&8 | SD34 | Ben Roethlisberger punts 25 yards to SD9, Center-Justin Hartwig. Downed | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | SD9 | Darren Sproles Off Left Guard to SD12 for 3 yards | | |
| SD | 2nd&7 | SD12 | Darren Sproles up the Middle to SD14 for 2 yards | | |
| SD | 3rd&5 | SD14 | Philip Rivers Pass Incomplete to Darren Sproles | | |
| SD | 4th&5 | SD14 | Mike Scifres punts 53 yards to Pit33, Center-David Binn. Santonio Holmes returns for 67 yards for a TOUCHDOWN | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed extra point is GOOD. Holder-Mitch Berger | | |
| Pit | | | Drive Stats: plays, yards, min sec | 7 | 7 |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 64 yards from Pit30 to SD6, Darren Sproles returns to SD36 for 30 yards | | |
| SD | | | SD-Jacob Hester PENALIZED -15 yards for Face Mask | | |
| SD | 1st&25 | SD21 | Philip Rivers Pass to Chris Chambers to SD33 for 12 yards | | |
| SD | 2nd&13 | SD33 | Philip Rivers Pass to Michael Bennett to SD39 for 6 yards | | |
| SD | 3rd&7 | SD39 | Philip Rivers Pass to Antonio Gates to SD47 for 8 yards | | |
| SD | 1st&10 | SD47 | SD-Marcus McNeill PENALIZED -5 yards for False Start | | |
| SD | 1st&15 | SD42 | Philip Rivers Pass to Darren Sproles to SD45 for 3 yards | | |
| SD | 2nd&12 | SD45 | Philip Rivers sacked at SD37 for -8 yards | | |
| SD | 3rd&20 | SD37 | SD-Philip Rivers PENALIZED -5 yards for Delay of Game | | |
| SD | 3rd&25 | SD32 | Darren Sproles Off Left Guard to SD33 for 1 yard | | |
| SD | 4th&24 | SD33 | Mike Scifres punts 41 yards to Pit26, Center-David Binn. Out of Bounds | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | Pit26 | Willie Parker Off Right Tackle to Pit27 for 1 yard | | |
| Pit | 2nd&9 | Pit27 | Ben Roethlisberger Pass Incomplete to Nate Washington | | |
| Pit | 3rd&9 | Pit27 | Ben Roethlisberger sacked at Pit23 for -4 yards | | |
| Pit | 4th&13 | Pit23 | Mitch Berger punts 49 yards to SD28, Center-Jared Retkofsky. Darren Sproles returns to SD28 for no gain | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | SD-Cletis Gordon PENALIZED -10 yards for Illegal Block | | |
| SD | 1st&10 | SD18 | Darren Sproles Off Right Guard to SD26 for 8 yards | | |
| SD | 2nd&2 | SD26 | Darren Sproles Off Right Tackle to SD30 for 4 yards | | |
| |
| Second Quarter |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | SD30 | Darren Sproles Off Right Guard to SD31 for 1 yard | | |
| SD | 2nd&9 | SD31 | Philip Rivers Pass to Antonio Gates to SD38 for 7 yards | | |
| SD | 3rd&2 | SD38 | Darren Sproles Off Left Guard to SD39 for 1 yard. Replay challenge - ruling upheld. | | |
| SD | 4th&1 | SD39 | San Diego Chargers timeout. | | |
| SD | 4th&1 | SD39 | Mike Scifres punts 43 yards to Pit18, Center-David Binn. Mewelde Moore Fair Catch | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | Pit18 | Willie Parker up the Middle to Pit25 for 7 yards | | |
| Pit | 2nd&3 | Pit25 | Willie Parker Off Right Tackle to Pit30 for 5 yards | | |
| Pit | 1st&10 | Pit30 | Willie Parker up the Middle to Pit36 for 6 yards | | |
| Pit | 2nd&4 | Pit36 | Willie Parker Off Right Guard to Pit41 for 5 yards | | |
| Pit | 1st&10 | Pit41 | Mewelde Moore Off Left Guard to Pit45 for 4 yards | | |
| Pit | 2nd&6 | Pit45 | Willie Parker Off Right Guard to Pit48 for 3 yards | | |
| Pit | 3rd&3 | Pit48 | Pit-Darnell Stapleton PENALIZED -5 yards for False Start | | |
| Pit | 3rd&8 | Pit43 | Ben Roethlisberger Pass to Carey Davis to Pit49 for 6 yards | | |
| Pit | 4th&2 | Pit49 | San Diego Chargers timeout. | | |
| Pit | 4th&2 | Pit49 | Mitch Berger punts 51 yards to SD0, Center-Jared Retkofsky. TOUCHBACK. | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | SD20 | Philip Rivers Pass Incomplete to Vincent Jackson | | |
| SD | 2nd&10 | SD20 | Philip Rivers Pass Incomplete to Jacob Hester | | |
| SD | 3rd&10 | SD20 | Philip Rivers Pass Incomplete to Vincent Jackson. Replay challenge - ruling reversed. | | |
| SD | 4th&10 | SD20 | Mike Scifres punts 41 yards to Pit39, Center-David Binn. Santonio Holmes Fair Catch | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | Pit39 | Santonio Holmes Off Right End to Pit42 for 3 yards | | |
| Pit | 2nd&7 | Pit42 | Ben Roethlisberger Pass to Nate Washington to Pit47 for 5 yards | | |
| Pit | 3rd&2 | Pit47 | Ben Roethlisberger Pass to Carey Davis to Pit48 for 1 yard | | |
| Pit | 4th&1 | Pit48 | Ryan Clark up the Middle to Pit44 for -4 yards | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | Pit44 | Darren Sproles Off Left Tackle to Pit45 for -1 yards | | |
| SD | 2nd&11 | Pit45 | Philip Rivers Pass Incomplete to Legedu Naanee | | |
| SD | 3rd&11 | Pit45 | Philip Rivers Pass to Antonio Gates to Pit30 for 15 yards | | |
| SD | 1st&10 | Pit30 | Darren Sproles up the Middle to Pit35 for -5 yards | | |
| SD | 2nd&15 | Pit35 | Philip Rivers Pass to Darren Sproles to Pit32 for 3 yards | | |
| SD | 3rd&12 | Pit32 | Philip Rivers Pass to Antonio Gates to Pit24 for 8 yards | | |
| SD | 4th&4 | Pit24 | Two-Minute Warning | | |
| SD | 4th&4 | Pit24 | Nate Kaeding 42 yard field goal is GOOD. Holder-Mike Scifres | | |
| SD | | | Drive Stats: 7 plays, 20 yards, 3min 9sec | 10 | 7 |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Mike Scifres kicks 50 yards from SD30 to Pit20, Gary Russell returns to Pit34 for 14 yards | | |
| Pit | 1st&10 | Pit34 | Ben Roethlisberger Pass to Santonio Holmes to Pit49 for 15 yards | | |
| Pit | 1st&10 | Pit49 | Ben Roethlisberger Pass to Mewelde Moore to SD42 for 9 yards | | |
| Pit | 2nd&1 | SD42 | San Diego Chargers timeout. | | |
| Pit | 2nd&1 | SD42 | Ben Roethlisberger Pass Incomplete to Heath Miller | | |
| Pit | 3rd&1 | SD42 | Gary Russell up the Middle to SD39 for 3 yards | | |
| Pit | 1st&10 | SD39 | Pittsburgh Steelers timeout. | | |
| Pit | 1st&10 | SD39 | Ben Roethlisberger Pass Incomplete to Santonio Holmes | | |
| Pit | | | Pit-Willie Colon PENALIZED -5 yards for Illegal Formation | | |
| Pit | 2nd&15 | SD44 | Ben Roethlisberger Pass to Hines Ward to SD3 for 41 yards | | |
| Pit | 1st&3 | SD3 | Pittsburgh Steelers timeout. | | |
| Pit | 1st&3 | SD3 | Willie Parker Off Left End for 3 yards for a TOUCHDOWN | | |
| Pit | | | Jeff Reed extra point is GOOD. Holder-Mitch Berger | | |
| Pit | | | Drive Stats: 7 plays, 66 yards, 1min 16sec | 10 | 14 |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 47 yards from Pit30 to SD23, Antonio Cromartie returns to SD30 for 7 yards | | |
| SD | 1st&10 | SD30 | Darren Sproles up the Middle to SD30 for no gain | | |
| Team | Down | Spot | Play | SD | Pit |
| |
| Third Quarter |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Nate Kaeding kicks 66 yards from SD30 to Pit4, Gary Russell returns to Pit23 for 19 yards | | |
| Pit | 1st&10 | Pit23 | Willie Parker up the Middle to Pit25 for 2 yards | | |
| Pit | 2nd&8 | Pit25 | Willie Parker Off Right End to Pit38 for 13 yards | | |
| Pit | 1st&10 | Pit38 | Willie Parker up the Middle to Pit42 for 4 yards | | |
| Pit | 2nd&6 | Pit42 | Willie Parker Off Left Guard to Pit41 for -1 yards | | |
| Pit | 3rd&7 | Pit41 | Ben Roethlisberger Pass to Santonio Holmes to SD49 for 10 yards | | |
| Pit | 1st&10 | SD49 | Ben Roethlisberger Pass Incomplete to Santonio Holmes | | |
| Pit | 2nd&10 | SD49 | Willie Parker up the Middle to SD50 for -1 yards | | |
| Pit | 3rd&11 | SD50 | Ben Roethlisberger Pass to Nate Washington to SD32 for 18 yards | | |
| Pit | 1st&10 | SD32 | Willie Parker Off Left Tackle to SD30 for 2 yards | | |
| Pit | 2nd&8 | SD30 | Ben Roethlisberger Pass to Carey Davis to SD30 for no gain | | |
| Pit | 3rd&8 | SD30 | Ben Roethlisberger Pass to Heath Miller to SD12 for 18 yards | | |
| Pit | 1st&10 | SD12 | Willie Parker Off Right Tackle to SD8 for 4 yards | | |
| Pit | 2nd&6 | SD8 | Ben Roethlisberger Pass to Heath Miller for 8 yards for a TOUCHDOWN | | |
| Pit | | | Jeff Reed extra point is GOOD. Holder-Mitch Berger | | |
| Pit | | | Drive Stats: 13 plays, 77 yards, 7min 56sec | 10 | 21 |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 56 yards from Pit30 to SD14, Darren Sproles returns to Pit23 for 63 yards | | |
| SD | 1st&10 | Pit23 | Philip Rivers pass intended for Vincent Jackson intercepted by Larry Foote RETURNED from Pit21 for no gain. Replay challenge - ruling upheld. | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | Pit21 | San Diego Chargers timeout. | | |
| Pit | 1st&10 | Pit21 | Willie Parker Off Right Tackle to Pit24 for 3 yards | | |
| Pit | 2nd&7 | Pit24 | Willie Parker Off Left End to Pit28 for 4 yards | | |
| Pit | 3rd&3 | Pit28 | Santonio Holmes End Around Right to Pit32 for 4 yards | | |
| Pit | 1st&10 | Pit32 | Willie Parker up the Middle to Pit36 for 4 yards | | |
| Pit | | | Pit-Heath Miller PENALIZED -10 yards for Holding | | |
| Pit | 2nd&16 | Pit26 | Mewelde Moore up the Middle to Pit31 for 5 yards | | |
| Pit | 3rd&11 | Pit31 | Ben Roethlisberger Pass to Mewelde Moore to Pit34 for 3 yards | | |
| Pit | 4th&8 | Pit34 | Mitch Berger punts 43 yards to SD23, Center-Jared Retkofsky. Eric Weddle returns to SD23 for no gain | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Eric Weddle FUMBLES, recovered at SD23 by William Gay RETURNED for 0 yards. | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | SD23 | Pit-Darnell Stapleton PENALIZED -5 yards for False Start | | |
| Pit | 1st&15 | SD28 | Ben Roethlisberger Pass Incomplete to Willie Parker | | |
| Pit | 2nd&15 | SD28 | Ben Roethlisberger Pass to Hines Ward to SD9 for 19 yards | | |
| Pit | | | SD-Cletis Gordon PENALIZED 5 yards for Unnecessary Roughness | | |
| Pit | 1st&4 | SD4 | Willie Parker up the Middle to SD1 for 3 yards | | |
| Pit | 2nd&1 | SD1 | Ben Roethlisberger Pass Incomplete to Gary Russell | | |
| Pit | 3rd&1 | SD1 | Gary Russell up the Middle to SD1 for no gain | | |
| |
| Fourth Quarter |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 4th&1 | SD1 | Carey Davis up the Middle to SD1 for no gain | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | SD1 | Philip Rivers Pass to Jacob Hester to SD12 for 11 yards | | |
| SD | 1st&10 | SD12 | Philip Rivers sacked at SD2 for -10 yards | | |
| SD | 2nd&20 | SD2 | Philip Rivers Pass Incomplete to Legedu Naanee | | |
| SD | 3rd&20 | SD2 | Philip Rivers Pass Incomplete to Antonio Gates | | |
| SD | 4th&20 | SD2 | Mike Scifres punts 53 yards to Pit45, Center-David Binn. Santonio Holmes returns to SD49 for 6 yards | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | SD49 | Willie Parker Off Right Tackle to SD45 for 4 yards | | |
| Pit | | | SD-Eric Weddle PENALIZED 44 yards for Pass Interference | | |
| Pit | 1st&1 | SD1 | Gary Russell Off Left Tackle for 1 yard for a TOUCHDOWN | | |
| Pit | | | Jeff Reed extra point is GOOD. Holder-Mitch Berger | | |
| Pit | | | Drive Stats: 2 plays, 49 yards, 49sec | 10 | 28 |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 73 yards from Pit30 to SD-3, Darren Sproles returns to SD27 for 30 yards | | |
| SD | 1st&10 | SD27 | Philip Rivers Pass to Vincent Jackson to SD35 for 8 yards | | |
| SD | 2nd&2 | SD35 | Philip Rivers sacked at SD27 for -8 yards | | |
| SD | 3rd&10 | SD27 | Philip Rivers Pass to Brandon Manumaleuna to SD41 for 14 yards | | |
| SD | 1st&10 | SD41 | Philip Rivers Pass to Darren Sproles to Pit48 for 11 yards | | |
| SD | 1st&10 | Pit48 | Philip Rivers Pass Incomplete to Jacob Hester | | |
| SD | 2nd&10 | Pit48 | Philip Rivers Pass Incomplete to Brandon Manumaleuna | | |
| SD | 3rd&10 | Pit48 | Philip Rivers Pass to Chris Chambers to Pit33 for 15 yards | | |
| SD | 1st&10 | Pit33 | Philip Rivers Pass Incomplete to Brandon Manumaleuna | | |
| SD | 2nd&10 | Pit33 | Philip Rivers Pass to Chris Chambers to Pit8 for 25 yards | | |
| SD | | | Pit-Troy Polamalu PENALIZED 4 yards for Roughing Passer | | |
| SD | 1st&4 | Pit4 | Philip Rivers Pass to Legedu Naanee for 4 yards for a TOUCHDOWN | | |
| SD | | | Nate Kaeding extra point is GOOD. Holder-Mike Scifres | | |
| SD | | | Drive Stats: 10 plays, 73 yards, 3min 43sec | 17 | 28 |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Nate Kaeding kicks 61 yards from SD30 to Pit9, Mewelde Moore returns to Pit27 for 18 yards | | |
| Pit | 1st&10 | Pit27 | Ben Roethlisberger Pass Incomplete to Nate Washington | | |
| Pit | 2nd&10 | Pit27 | Pittsburgh Steelers timeout. | | |
| Pit | 2nd&10 | Pit27 | Ben Roethlisberger Pass to Nate Washington to Pit34 for 7 yards | | |
| Pit | 3rd&3 | Pit34 | Ben Roethlisberger Pass to Hines Ward to Pit43 for 9 yards | | |
| Pit | 1st&10 | Pit43 | Willie Parker Off Right Guard to Pit45 for 2 yards | | |
| Pit | 2nd&8 | Pit45 | Willie Parker Off Right End to SD28 for 27 yards | | |
| Pit | 1st&10 | SD28 | Willie Parker Off Left Guard to SD21 for 7 yards | | |
| Pit | 2nd&3 | SD21 | Mewelde Moore Off Left End to SD17 for 4 yards | | |
| Pit | 1st&10 | SD17 | Willie Parker Off Right Tackle to SD16 for 1 yard | | |
| Pit | 2nd&9 | SD16 | Willie Parker Off Right End for 16 yards for a TOUCHDOWN | | |
| Pit | | | Jeff Reed extra point is GOOD. Holder-Mitch Berger | | |
| Pit | | | Drive Stats: 9 plays, 73 yards, 4min 58sec | 17 | 35 |
| Team | Down | Spot | Play | SD | Pit |
| Pit | | | Jeff Reed kicks 69 yards from Pit30 to SD1, Darren Sproles returns to SD24 for 23 yards | | |
| SD | 1st&10 | SD24 | Philip Rivers Pass Incomplete to Vincent Jackson | | |
| SD | 2nd&10 | SD24 | Philip Rivers Pass Incomplete to Vincent Jackson | | |
| SD | 3rd&10 | SD24 | Philip Rivers sacked at SD17 for -7 yards | | |
| SD | 4th&17 | SD17 | Mike Scifres punts 52 yards to Pit31, Center-David Binn. Mewelde Moore Fair Catch | | |
| Team | Down | Spot | Play | SD | Pit |
| Pit | 1st&10 | Pit31 | Gary Russell Off Left Tackle to Pit32 for 1 yard | | |
| Pit | 2nd&9 | Pit32 | San Diego Chargers timeout. | | |
| Pit | 2nd&9 | Pit32 | Byron Leftwich up the Middle to Pit34 for 2 yards | | |
| Pit | 3rd&7 | Pit34 | San Diego Chargers timeout. | | |
| Pit | 3rd&7 | Pit34 | Byron Leftwich Pass Incomplete to Limas Sweed | | |
| Pit | 4th&7 | Pit34 | Mitch Berger punts 49 yards to SD17, Center-Jared Retkofsky. Darren Sproles returns to SD21 for 4 yards | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | 1st&10 | SD21 | Philip Rivers Pass to Chris Chambers to SD41 for 20 yards | | |
| SD | 1st&10 | SD41 | Philip Rivers Pass to Jacob Hester to SD43 for 2 yards | | |
| SD | 2nd&8 | SD43 | Philip Rivers Pass Incomplete to Vincent Jackson. Replay challenge - ruling upheld. | | |
| SD | 3rd&13 | SD38 | Pittsburgh Steelers timeout. | | |
| SD | 3rd&8 | SD38 | SD-Philip Rivers PENALIZED -5 yards for Delay of Game | | |
| SD | 3rd&13 | SD38 | Philip Rivers Pass to Darren Sproles for 62 yards for a TOUCHDOWN | | |
| SD | | | Two-Minute Warning | | |
| SD | | | Nate Kaeding extra point is GOOD. Holder-Mike Scifres | | |
| SD | | | Drive Stats: 4 plays, 79 yards, 50sec | 24 | 35 |
| SD | | | Pit-William Gay PENALIZED 5 yards for Offside | | |
| Team | Down | Spot | Play | SD | Pit |
| SD | | | Mike Scifres ONSIDE kicks 13 yards from SD35 to SD48, Gary Russell returns to SD48 for no gain | | |
| Pit | 1st&10 | SD48 | Byron Leftwich Kneel to Runout Clock to SD50 for -2 yards | | |
| Pit | 2nd&12 | SD50 | Byron Leftwich Kneel to Runout Clock to Pit49 for -1 yards | | |
| Pit | 3rd&13 | Pit49 | Byron Leftwich Kneel to Runout Clock to Pit48 for -1 yards | | |