NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | S. Barrett | TB | 16 | 58 | 19.5 | 138.5 | 1 | 6 | 2 |
| 2 | C. Jones | Ari | 16 | 53 | 19.0 | 146.0 | 0 | 8 | 5 |
| 3 | C. Jordan | NO | 16 | 53 | 15.5 | 98.0 | 0 | 0 | 3 |
| 4t | D. Hunter | Min | 16 | 70 | 14.5 | 113.5 | 0 | 3 | 0 |
| 4t | T. Watt | Pit | 16 | 55 | 14.5 | 104.0 | 2 | 8 | 8 |
| 6 | Z. Smith | GB | 16 | 55 | 13.5 | 112.5 | 0 | 1 | 0 |
| 7 | A. Donald | LAR | 16 | 48 | 12.5 | 69.5 | 0 | 2 | 2 |
| 8 | P. Smith | GB | 16 | 56 | 12.0 | 88.0 | 1 | 1 | 4 |
| 9t | J. Bosa | LAC | 16 | 67 | 11.5 | 78.5 | 0 | 1 | 0 |
| 9t | B. Dupree | Pit | 16 | 68 | 11.5 | 57.0 | 0 | 4 | 3 |
| 9t | D. Fowler Jr. | LAR | 16 | 58 | 11.5 | 84.0 | 0 | 2 | 6 |
| 9t | R. Quinn | Dal | 14 | 34 | 11.5 | 86.0 | 0 | 2 | 3 |
| 13 | J. Houston | Ind | 16 | 44 | 11.0 | 66.0 | 0 | 2 | 0 |
| 14 | J. Allen | Jax | 16 | 44 | 10.5 | 74.0 | 0 | 2 | 0 |
| 15t | A. Armstead | SF | 16 | 54 | 10.0 | 73.0 | 0 | 2 | 2 |
| 15t | M. Crosby | Oak | 16 | 46 | 10.0 | 69.5 | 0 | 4 | 4 |
| 15t | M. Garrett | Cle | 10 | 29 | 10.0 | 63.0 | 0 | 2 | 0 |
| 15t | M. Golden | NYG | 16 | 72 | 10.0 | 71.5 | 0 | 0 | 0 |
| 19t | M. Addison | Car | 15 | 34 | 9.5 | 53.5 | 0 | 2 | 0 |
| 19t | M. Judon | Bal | 16 | 54 | 9.5 | 85.5 | 0 | 4 | 0 |
| 19t | J. Phillips | Buf | 16 | 31 | 9.5 | 71.5 | 0 | 1 | 0 |
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