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NFL Leaders |
Rushing Yards Gained
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1 | K. Hunt | KC | 16 | 272 | 1327 | 82.9 | 4.88 | 8 |
| 2 | T. Gurley II | LAR | 15 | 279 | 1305 | 87.0 | 4.68 | 13 |
| 3 | L. Bell | Pit | 15 | 321 | 1291 | 86.1 | 4.02 | 9 |
| 4 | L. McCoy | Buf | 16 | 287 | 1138 | 71.1 | 3.97 | 6 |
| 5 | M. Ingram | NO | 16 | 230 | 1124 | 70.3 | 4.89 | 12 |
| 6 | J. Howard | Chi | 16 | 276 | 1122 | 70.1 | 4.07 | 9 |
| 7 | M. Gordon | LAC | 16 | 284 | 1105 | 69.1 | 3.89 | 8 |
| 8 | L. Fournette | Jax | 13 | 268 | 1040 | 80.0 | 3.88 | 9 |
| 9 | C. Anderson | Den | 16 | 245 | 1007 | 62.9 | 4.11 | 3 |
| 10 | E. Elliott | Dal | 10 | 242 | 983 | 98.3 | 4.06 | 7 |
| 11 | A. Collins | Bal | 15 | 212 | 973 | 64.9 | 4.59 | 6 |
| 12 | F. Gore | Ind | 16 | 261 | 961 | 60.1 | 3.68 | 3 |
| 13 | C. Hyde | SF | 16 | 240 | 938 | 58.6 | 3.91 | 8 |
| 14 | D. Lewis | NE | 16 | 180 | 896 | 56.0 | 4.98 | 6 |
| 15 | M. Lynch | Oak | 15 | 207 | 891 | 59.4 | 4.30 | 7 |
| 16 | L. Miller | Hou | 16 | 238 | 888 | 55.5 | 3.73 | 3 |
| 17 | J. Ajayi | Phi | 14 | 208 | 873 | 62.4 | 4.20 | 1 |
| 18 | D. Freeman | Atl | 14 | 196 | 865 | 61.8 | 4.41 | 7 |
| 19 | I. Crowell | Cle | 16 | 206 | 853 | 53.3 | 4.14 | 2 |
| 20 | L. Murray | Min | 16 | 216 | 842 | 52.6 | 3.90 | 8 |
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