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NFL Leaders |
| Rank | Name | Team | G | Rushes | Yds | Yd/G | Avg | TD |
| 1 | C. Spiller | Buf | 16 | 207 | 1244 | 77.8 | 6.01 | 6 |
| 2 | J. Charles | KC | 16 | 285 | 1509 | 94.3 | 5.29 | 5 |
| 3 | B. Pierce | Bal | 16 | 108 | 532 | 33.3 | 4.93 | 1 |
| 4 | M. Jones-Drew | Jac | 6 | 86 | 414 | 69.0 | 4.81 | 1 |
| 5 | C. Johnson | Ten | 16 | 276 | 1243 | 77.7 | 4.50 | 6 |
| 6 | R. Rice | Bal | 16 | 257 | 1143 | 71.4 | 4.45 | 9 |
| 7 | W. McGahee | Den | 10 | 167 | 731 | 73.1 | 4.38 | 4 |
| 8 | S. Ridley | NE | 16 | 290 | 1263 | 78.9 | 4.36 | 12 |
| 9 | R. Bush | Mia | 16 | 227 | 986 | 61.6 | 4.34 | 6 |
| 10 | A. Foster | Hou | 16 | 351 | 1424 | 89.0 | 4.06 | 15 |
| 11 | J. Dwyer | Pit | 13 | 156 | 623 | 47.9 | 3.99 | 2 |
| 12 | B. Powell | NYJ | 14 | 110 | 437 | 31.2 | 3.97 | 4 |
| 13 | B. Green-Ellis | Cin | 15 | 278 | 1094 | 72.9 | 3.94 | 6 |
| 14 | R. Hillman | Den | 14 | 85 | 330 | 23.6 | 3.88 | 1 |
| 15 | D. Brown | Ind | 10 | 108 | 417 | 41.7 | 3.86 | 1 |
| 16 | V. Ballard | Ind | 16 | 211 | 814 | 50.9 | 3.86 | 2 |
| 17 | S. Greene | NYJ | 16 | 276 | 1063 | 66.4 | 3.85 | 8 |
| 18 | R. Mathews | SD | 12 | 184 | 707 | 58.9 | 3.84 | 1 |
| 19 | K. Moreno | Den | 8 | 138 | 525 | 65.6 | 3.80 | 4 |
| 20 | F. Jackson | Buf | 10 | 115 | 437 | 43.7 | 3.80 | 3 |