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NFL Leaders |
%Sacks/Attempt
| Rank | Player | Team | Stats |
| 1 | Peyton Manning | Den | 3.5 ( 21/604 ) |
| 2 | Tom Brady | NE | 4.1 ( 27/664 ) |
| 3 | Carson Palmer | Oak | 4.4 ( 26/591 ) |
| 4 | Matt Schaub | Hou | 4.7 ( 27/571 ) |
| 5 | Brandon Weeden | Cle | 5.1 ( 28/545 ) |
| 6 | Ryan Fitzpatrick | Buf | 5.6 ( 30/535 ) |
| 7 | Matt Hasselbeck | Ten | 6.0 ( 14/235 ) |
| 8 | Andrew Luck | Ind | 6.1 ( 41/668 ) |
| 9 | Joe Flacco | Bal | 6.2 ( 35/566 ) |
| 10 | Ben Roethlisberger | Pit | 6.3 ( 30/479 ) |
| 11 | Matt Cassel | KC | 6.4 ( 19/296 ) |
| 12 | Ryan Tannehill | Mia | 6.7 ( 35/519 ) |
| 13 | Mark Sanchez | NYJ | 7.0 ( 34/487 ) |
| 14 | Blaine Gabbert | Jac | 7.3 ( 22/300 ) |
| 15 | Jake Locker | Ten | 7.4 ( 25/339 ) |
| 16 | Andy Dalton | Cin | 8.0 ( 46/574 ) |
| 17 | Chad Henne | Jac | 8.3 ( 28/336 ) |
| 18 | Philip Rivers | SD | 8.5 ( 49/576 ) |
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