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| 1:25 PM PT2:25 PM MT3:25 PM CT4:25 PM ET20:25 GMT4:25 1:25 PM MST3:25 PM EST2:25 PM CT0:25 UAE (+1)16:25 ET19:25 , October 10, 2021 State Farm Stadium, Glendale, Arizona Attendance: 62,716 |
| First Quarter | SF | Ari | |
 |
James Conner 1 yd run (Matt Prater kick) 9:02 8 Plays , 66 Yards, 3:44 |
0 | 7 |
| Second Quarter | SF | Ari | |
|
Matt Prater 21 yd FG 5:27 14 Plays , 96 Yards, 5:59 |
0 | 10 |
| Third Quarter | SF | Ari | |
 |
Deebo Samuel 13 yd run (Joey Slye kick) 1:42 6 Plays , 59 Yards, 3:28 |
7 | 10 |
| Fourth Quarter | SF | Ari | |
|
DeAndre Hopkins 9 yd pass from Kyler Murray (Matt Prater kick) 5:13 5 Plays , 52 Yards, 2:36 |
7 | 17 |
|
Joey Slye 47 yd FG 4:12 6 Plays , 46 Yards, 1:01 |
10 | 17 |
| San Francisco | Arizona | |
| First Downs | 19 | 20 |
| Rushing | 7 | 8 |
| Passing | 9 | 11 |
| Penalty | 3 | 1 |
| 3rd Down Efficiency | 3-11, 27% | 3-10, 30% |
| 4th down efficiency | 1-5, 20% | 0-0, -% |
| Red-Zone Efficiency | 1-2, 50% | 2-3, 67% |
| Goal-To-Go Efficiency | 0-1, 0% | 2-3, 67% |
| Total Net Yards | 338 | 304 |
| Total Plays | 59 | 60 |
| Yards/Play | 5.7 | 5.1 |
| Net Rushing Yards | 152 | 94 |
| Rushes | 28 | 27 |
| Yards/Carry | 5.4 | 3.5 |
| Rushing TDs | 1 | 1 |
| Net Passing Yards | 186 | 210 |
| Comp-Att-Int | 15-29-1 | 22-31-0 |
| Yards/Attempt | 6.0 | 6.4 |
| Passing TDs | 0 | 1 |
| Sack-Yds | 2-6 | 2-29 |
| Return Yards | 6 | 29 |
| Punt Returns-Yards | 2-6 | 1-12 |
| Punt Return TDs | 0 | 0 |
| Kick Returns-Yards | 0-0 | 0-0 |
| Kick Return TDs | 0 | 0 |
| Int Returns-Yards | 0-0 | 1-17 |
| Int Return TDs | 0 | 0 |
| Punts-Average | 2-48.5 | 4-51.3 |
| Penalties - Yards | 7-60 | 6-62 |
| Fumbles Lost | 0-0 | 4-1 |
| Own-Recover-Yards | 0-0 | 3-3 |
| Own-Recover TDs | 0 | 0 |
| Opp-Recover-Yards | 1-0 | 0-0 |
| Opp-Recover TDs | 0 | 0 |
| Field Goals | 1-1, 100% | 1-2, 50% |
| Extra Points | 1-1, 100% | 2-2, 100% |
| Two Point Conversions | 0-0, -% | 0-0, -% |
| Safeties | 0 | 0 |
| Time of Possession | 31:54 | 28:06 |
| San Francisco Passing | ||||||
| Player | Cmp | Att | Comp % | Yds | TDs | Int |
| T. Lance | 15 | 29 | 51.7 | 192 | 0 | 1 |
| Arizona Passing | ||||||
| Player | Cmp | Att | Comp % | Yds | TDs | Int |
| K. Murray | 22 | 31 | 71.0 | 239 | 1 | 0 |
| San Francisco Rushing | ||||
| Player | Carries | Yds | Avg | TDs |
| T. Lance | 16 | 89 | 5.6 | 0 |
| E. Mitchell | 9 | 43 | 4.8 | 0 |
| D. Samuel | 1 | 13 | 13.0 | 1 |
| T. Sermon | 1 | 7 | 7.0 | 0 |
| K. Juszczyk | 1 | 0 | 0 | 0 |
| Arizona Rushing | ||||
| Player | Carries | Yds | Avg | TDs |
| R. Moore | 3 | 38 | 12.7 | 0 |
| J. Conner | 10 | 29 | 2.9 | 1 |
| C. Edmonds | 6 | 15 | 2.5 | 0 |
| C. Kirk | 1 | 11 | 11.0 | 0 |
| K. Murray | 7 | 1 | 0.1 | 0 |
| San Francisco Receiving | ||||
| Player | Rec | Yds | Avg | TDs |
| D. Samuel | 3 | 58 | 19.3 | 0 |
| K. Juszczyk | 3 | 35 | 11.7 | 0 |
| B. Aiyuk | 2 | 32 | 16.0 | 0 |
| R. Dwelley | 2 | 25 | 12.5 | 0 |
| E. Mitchell | 2 | 19 | 9.5 | 0 |
| M. Sanu Sr. | 2 | 19 | 9.5 | 0 |
| C. Woerner | 1 | 4 | 4.0 | 0 |
| T. Benjamin | 0 | 0 | 0 | 0 |
| Arizona Receiving | ||||
| Player | Rec | Yds | Avg | TDs |
| D. Hopkins | 6 | 87 | 14.5 | 1 |
| R. Moore | 5 | 59 | 11.8 | 0 |
| C. Kirk | 5 | 39 | 7.8 | 0 |
| C. Edmonds | 3 | 19 | 6.3 | 0 |
| M. Williams | 1 | 14 | 14.0 | 0 |
| A. Green | 1 | 13 | 13.0 | 0 |
| J. Conner | 1 | 8 | 8.0 | 0 |
| San Francisco Kicking Statistics | ||||
| Player | FG | Made | Missed | XP |
| J. Slye | 1/1 | 47 | - | 1/1 |
| Arizona Kicking Statistics | ||||
| Player | FG | Made | Missed | XP |
| M. Prater | 1/2 | 21 | 61 | 2/2 |
| San Francisco Fumbles | |
| Player | Fumbles |
| Arizona Fumbles | |
| Player | Fumbles |
| A. Lee | 1 |
| C. Edmonds | 1 |
| K. Murray | 2 |
| San Francisco Fumbles Lost | |
| Player | Fumbles Lost |
| Arizona Fumbles Lost | |
| Player | Fumbles Lost |
| C. Edmonds | 1 |
| San Francisco Defensive Statistics | ||||
| Player | TK | Asst | Sack-Yds | PD |
| F. Warner | 7 | 2 | 0-0 | 0 |
| N. Bosa | 4 | 1 | 1-15 | 0 |
| E. Moseley | 4 | 1 | 0-0 | 1 |
| D. Jones | 4 | 0 | 1-14 | 0 |
| J. Tartt | 3 | 4 | 0-0 | 0 |
| J. Ward | 3 | 4 | 0-0 | 0 |
| J. Norman | 3 | 3 | 0-0 | 1 |
| D. Johnson | 3 | 0 | 0-0 | 0 |
| M. Harris | 1 | 2 | 0-0 | 0 |
| A. Al-Shaair | 1 | 2 | 0-0 | 0 |
| S. Ebukam | 1 | 1 | 0-0 | 0 |
| M. Hurst | 1 | 0 | 0-0 | 0 |
| A. Armstead | 0 | 2 | 0-0 | 0 |
| R. Dwelley | 0 | 0 | 0-0 | 0 |
| T. Cannon | 0 | 0 | 0-0 | 0 |
| A. Key | 0 | 1 | 0-0 | 0 |
| K. Street | 0 | 1 | 0-0 | 0 |
| Arizona Defensive Statistics | ||||
| Player | TK | Asst | Sack-Yds | PD |
| J. Thompson | 6 | 0 | 0-0 | 0 |
| B. Baker | 5 | 1 | 0-0 | 1 |
| J. Hicks | 4 | 2 | 0-0 | 0 |
| A. Hamilton | 4 | 2 | 0-0 | 0 |
| Z. Allen | 4 | 1 | 1-6 | 0 |
| J. Watt | 3 | 0 | 0-0 | 1 |
| Z. Collins | 2 | 2 | 0-0 | 0 |
| I. Simmons | 2 | 1 | .5-0 | 1 |
| J. Whittaker | 2 | 1 | 0-0 | 0 |
| M. Golden | 2 | 1 | 0-0 | 0 |
| R. Alford | 2 | 0 | 0-0 | 0 |
| R. Lawrence | 2 | 0 | 0-0 | 0 |
| Z. Turner | 1 | 0 | 0-0 | 0 |
| T. Vallejo | 0 | 2 | .5-0 | 0 |
| J. Ward | 0 | 0 | 0-0 | 0 |
| D. Kennard | 0 | 1 | 0-0 | 0 |
| E. Benjamin | 0 | 0 | 0-0 | 0 |
| L. Fotu | 0 | 0 | 0-0 | 2 |
| San Francisco Interceptions | ||
| Player | Int | Yds |
| Arizona Interceptions | ||
| Player | Int | Yds |
| B. Baker | 1 | 17 |
| San Francisco Punt Returns | |||
| Player | Ret | Yds | Avg |
| B. Aiyuk | 2 | 6 | 3.0 |
| Arizona Punt Returns | |||
| Player | Ret | Yds | Avg |
| R. Moore | 1 | 12 | 12.0 |
| San Francisco Kick Returns | |||
| Player | Ret | Yds | Avg |
| Arizona Kick Returns | |||
| Player | Ret | Yds | Avg |
| San Francisco Punting | |||||
| Player | Punts | Blocks | Yds | Avg | in 20 |
| M. Wishnowsky | 2 | 0 | 97 | 48.5 | 1 |
| Arizona Punting | |||||
| Player | Punts | Blocks | Yds | Avg | in 20 |
| A. Lee | 4 | 0 | 205 | 51.3 | 1 |
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